KEGG   ENZYME: 3.1.3.62Help
Entry
EC 3.1.3.62                 Enzyme                                 
Name
multiple inositol-polyphosphate phosphatase;
inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase;
inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase;
inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase;
inositol tetrakisphosphate phosphomonoesterase;
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase;
MIPP
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
1D-myo-inositol-hexakisphosphate 5-phosphohydrolase
Reaction(IUBMB)
myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate [RN:R07584]
Reaction(KEGG)
Substrate
myo-inositol hexakisphosphate [CPD:C01204];
H2O [CPD:C00001]
Product
myo-inositol pentakisphosphate [CPD:C15991];
phosphate [CPD:C00009]
Comment
This enzyme exists in two isoforms. It also acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3.
Pathway
Inositol phosphate metabolism
Orthology
K03103  
multiple inositol-polyphosphate phosphatase
Genes
HSA: 
9562(MINPP1)
PTR: 
450579(MINPP1)
PPS: 
100980933(MINPP1)
GGO: 
101144263(MINPP1)
PON: 
100173135(MINPP1)
MCC: 
704362(MINPP1)
MMU: 
17330(Minpp1)
RNO: 
29688(Minpp1)
CFA: 
486462(MINPP1)
AML: 
FCA: 
101091150(MINPP1)
BTA: 
541067(MINPP1)
SSC: 
100152243(MINPP1)
ECB: 
100062448(MINPP1)
MDO: 
100022488
SHR: 
100924973
OAA: 
100075018
GGA: 
395356(MINPP1)
MGP: 
100540797
TGU: 
100225117(MINPP1)
ACS: 
100555619
XTR: 
100493648
DRE: 
394075(minpp1b) 561891(minpp1a)
TRU: 
101067449
OLA: 
101172268 101174333
BFO: 
BRAFLDRAFT_203189
CIN: 
100186130
SPU: 
100891283
DME: 
Dmel_CG4317(Mipp2)
DSE: 
Dsec_GM12595
DSI: 
Dsim_GD16214
DGR: 
Dgri_GH24109
DMO: 
Dmoj_GI16368
DVI: 
Dvir_GJ16740
AGA: 
AgaP_AGAP003555
AAG: 
AaeL_AAEL011421
CQU: 
CpipJ_CPIJ002955
AME: 
725931
API: 
100167959
PHU: 
Phum_PHUM354750
ISC: 
IscW_ISCW003591
SMM: 
Smp_179560
NVE: 
NEMVE_v1g197800
HMG: 
100198610
CSV: 
101205988
VVI: 
100253622
SMO: 
SELMODRAFT_181288 SELMODRAFT_182070
PPP: 
PHYPADRAFT_199305
DPP: 
DICPUDRAFT_7448
EHI: 
EHI_059910(101.t00003)
EDI: 
EDI_223820
PIF: 
PITG_02783
 » show all
Taxonomy
Reference
1  [PMID:2786415]
  Authors
Cullen PJ, Irvine RF, Drobak BK, Dawson AP.
  Title
Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate.
  Journal
Biochem. J. 259 (1989) 931-3.
  Organism
Mus musculus [GN:mmu]
Reference
2  [PMID:9359836]
  Authors
Craxton A, Caffrey JJ, Burkhart W, Safrany ST, Shears SB.
  Title
Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase.
  Journal
Biochem. J. 328 ( Pt 1) (1997) 75-81.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
116958-30-6
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