| Entry |
|
|---|
| Name |
multiple inositol-polyphosphate phosphatase;
inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase;
inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase;
inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase;
inositol tetrakisphosphate phosphomonoesterase;
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase;
MIPP |
|---|
| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
 |
|---|
| Sysname |
1D-myo-inositol-hexakisphosphate 5-phosphohydrolase |
|---|
| Reaction(IUBMB) |
myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate
(mixed isomers) + phosphate [RN:R07584] |
|---|
| Reaction(KEGG) |
R07584 > R03371 R03372 R07583;
(other) R03434
 |
|---|
| Substrate |
myo-inositol hexakisphosphate [CPD:C01204];
H2O [CPD:C00001] |
|---|
| Product |
myo-inositol pentakisphosphate [CPD:C15991];
phosphate [CPD:C00009] |
|---|
| Comment |
This enzyme exists in two isoforms. It also acts on Ins(1,3,4,5)P4
to yield Ins(1,4,5)P3. |
|---|
| Pathway |
PATH: ec00562 Inositol phosphate metabolism |
|---|
| Orthology |
KO: K03103 multiple inositol-polyphosphate phosphatase |
|---|
| Genes |
HSA: 9562(MINPP1)
PTR: 450579(MINPP1)
MCC: 704362(MINPP1)
MMU: 17330(Minpp1)
RNO: 29688(Minpp1)
CFA: 486462(MINPP1)
BTA: 541067(MINPP1)
SSC: 100152243
ECB: 100062448
MDO: 100022488
GGA: 395356(MINPP1)
TGU: 100225117
DRE: 394075(minpp1)
DME: Dmel_CG4317(Mipp2)
NVE: NEMVE_v1g197800
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:2786415]
Cullen PJ, Irvine RF, Drobak BK, Dawson AP.
Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from
permeabilized mouse lymphoma L1210 cells by its conversion into
inositol 1,4,5-trisphosphate.
Biochem. J. 259 (1989) 931-3.
Mus musculus [GN:mmu] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:9359836]
Craxton A, Caffrey JJ, Burkhart W, Safrany ST, Shears SB.
Molecular cloning and expression of a rat hepatic multiple inositol
polyphosphate phosphatase.
Biochem. J. 328 ( Pt 1) (1997) 75-81.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.1.3.62
IUBMB Enzyme Nomenclature: 3.1.3.62
ExPASy - ENZYME nomenclature database: 3.1.3.62
BRENDA, the Enzyme Database: 3.1.3.62
CAS: 116958-30-6 |
|---|
