KEGG   ENZYME: 3.1.3.62Help
Entry
EC 3.1.3.62                 Enzyme                                 

Name
multiple inositol-polyphosphate phosphatase;
inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase;
inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase;
inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase;
inositol tetrakisphosphate phosphomonoesterase;
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase;
MIPP
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
1D-myo-inositol-hexakisphosphate 5-phosphohydrolase
Reaction(IUBMB)
myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate [RN:R07584]
Reaction(KEGG)
Substrate
myo-inositol hexakisphosphate [CPD:C01204];
H2O [CPD:C00001]
Product
myo-inositol pentakisphosphate [CPD:C15991];
phosphate [CPD:C00009]
Comment
This enzyme exists in two isoforms. It also acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3.
Pathway
Inositol phosphate metabolism
Orthology
K03103  
multiple inositol-polyphosphate phosphatase
Genes
HSA: 
9562(MINPP1)
PTR: 
450579(MINPP1)
PPS: 
100980933(MINPP1)
GGO: 
101144263(MINPP1)
PON: 
100173135(MINPP1)
MCC: 
704362(MINPP1)
MMU: 
17330(Minpp1)
RNO: 
29688(Minpp1)
CFA: 
486462(MINPP1)
AML: 
FCA: 
101091150(MINPP1)
BTA: 
541067(MINPP1)
SSC: 
100152243(MINPP1)
ECB: 
100062448(MINPP1)
MDO: 
SHR: 
OAA: 
GGA: 
395356(MINPP1)
MGP: 
TGU: 
100225117(MINPP1)
ACS: 
XTR: 
DRE: 
394075(minpp1b) 561891(minpp1a)
TRU: 
OLA: 
BFO: 
CIN: 
SPU: 
DME: 
DSE: 
DSI: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
API: 
PHU: 
ISC: 
SMM: 
NVE: 
HMG: 
CSV: 
VVI: 
SMO: 
PPP: 
DPP: 
EHI: 
EHI_059910(101.t00003)
EDI: 
PIF: 
 » show all
Taxonomy
Reference
1  [PMID:2786415]
  Authors
Cullen PJ, Irvine RF, Drobak BK, Dawson AP.
  Title
Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate.
  Journal
Biochem. J. 259 (1989) 931-3.
  Organism
Mus musculus [GN:mmu]
Reference
2  [PMID:9359836]
  Authors
Craxton A, Caffrey JJ, Burkhart W, Safrany ST, Shears SB.
  Title
Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase.
  Journal
Biochem. J. 328 ( Pt 1) (1997) 75-81.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
116958-30-6

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