| Entry |
|
|---|
| Name |
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase;
PTEN, MMAC1;
phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase |
|---|
| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
 |
|---|
| Sysname |
1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate
3-phosphohydrolase |
|---|
| Reaction(IUBMB) |
phosphatidylinositol 3,4,5-trisphosphate + H2O =
phosphatidylinositol 4,5-bisphosphate + phosphate [RN:R04513] |
|---|
| Reaction(KEGG) |
R04513
 |
|---|
| Substrate |
phosphatidylinositol 3,4,5-trisphosphate;
H2O [CPD:C00001] |
|---|
| Product |
phosphatidylinositol 4,5-bisphosphate;
phosphate [CPD:C00009] |
|---|
| Cofactor |
Magnesium [CPD:C00305] |
|---|
| Comment |
Requires Mg2+. Does not dephosphorylate inositol 4,5-bisphosphate.
This enzyme still works when the 2,3-bis(acyloxy)propyl group is
removed, i.e., it hydrolyses Ins(1,3,4,5)P4 to Ins(1,4,5)P3 |
|---|
| Pathway |
PATH: ec00562 Inositol phosphate metabolism
PATH: ec04070 Phosphatidylinositol signaling system |
|---|
| Orthology |
KO: K01110 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase |
|---|
| Genes |
HSA: 5728(PTEN)
PTR: 466142(PTEN)
MCC: 705121(PTEN)
MMU: 19211(Pten)
RNO: 50557(Pten)
CFA: 403832(PTEN)
BTA: 540786(PTEN)
SSC: 100156264(PTEN)
ECB: 100062388
MDO: 100013036
OAA: 100074365
GGA: 423675(PTEN)
TGU: 100224148
XLA: 399142(pten)
XTR: 100144716(pten)
DRE: 368415(ptenb) 794088(ptena)
BFO: BRAFLDRAFT_209333
CIN: 100182434
SPU: 590938
DME: Dmel_CG5671(Pten)
DPO: Dpse_GA19047
DAN: Dana_GF14124
DER: Dere_GG23962
DPE: Dper_GL19174
DSE: Dsec_GM11890
DSI: Dsim_GD22287
DYA: Dyak_GE26252
DGR: Dgri_GH13854
DMO: Dmoj_GI18266
AGA: AgaP_AGAP009628
AME: 411859(Pten)
NVI: 100117148(Pten)
TCA: 663870
API: 100163194(Pten)
ISC: IscW_ISCW021211
NVE: NEMVE_v1g131389
TAD: TRIADDRAFT_28654
ATH: AT3G19420(ATPEN2) AT3G50110(ATPEN3)
POP: POPTR_1083067 POPTR_259295 POPTR_722258
RCU: RCOM_0169080 RCOM_0812140
VVI: 100246943 100259289
OSA: 4352052(Os12g0407500)
SBI: SORBI_02g000980(SORBIDRAFT_02g000980)
PPP: PHYPADRAFT_11763 PHYPADRAFT_140952
SPO: SPBC609.02(ptn1)
MBR: MONBRDRAFT_38555
DDI: DDB_0191093(pteN)
EHI: EHI_197010
EDI: EDI_121930 EDI_295380
TET: TTHERM_00313160 TTHERM_00538950
PTM: GSPATT00010636001 GSPATT00016229001 GSPATT00019581001
GSPATT00021624001
TCR: 510879.160
GLA: GL50803_16728
TVA: TVAG_044400 TVAG_187740
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:8681945]
Kabuyama Y, Nakatsu N, Homma Y, Fukui Y.
Purification and characterization of the
phosphatidylinositol-3,4,5-trisphosphate phosphatase in bovine
thymus.
Eur. J. Biochem. 238 (1996) 350-6.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:9593664]
Maehama T, Dixon JE.
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second
messenger, phosphatidylinositol 3,4,5-trisphosphate.
J. Biol. Chem. 273 (1998) 13375-8.
Homo sapiens [GN:hsa] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.1.3.67
IUBMB Enzyme Nomenclature: 3.1.3.67
ExPASy - ENZYME nomenclature database: 3.1.3.67
BRENDA, the Enzyme Database: 3.1.3.67
CAS: 210488-47-4 |
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