KEGG   ENZYME: 3.1.3.9Help
Entry
EC 3.1.3.9                  Enzyme                                 
Name
glucose-6-phosphatase;
glucose 6-phosphate phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
D-glucose-6-phosphate phosphohydrolase
Reaction(IUBMB)
D-glucose 6-phosphate + H2O = D-glucose + phosphate [RN:R00303]
Reaction(KEGG)
Substrate
D-glucose 6-phosphate [CPD:C00092];
H2O [CPD:C00001]
Product
D-glucose [CPD:C00031];
phosphate [CPD:C00009]
Comment
Wide distribution in animal tissues. Also catalyses potent transphosphorylations from carbamoyl phosphate, hexose phosphates, diphosphate, phosphoenolpyruvate and nucleoside di- and triphosphates, to D-glucose, D-mannose, 3-methyl-D-glucose or 2-deoxy-D-glucose [cf. EC 2.7.1.62 (phosphoramidate---hexose phosphotransferase), EC 2.7.1.79 (diphosphate---glycerol phosphotransferase) and EC 3.9.1.1 (phosphoamidase)].
Pathway
Glycolysis / Gluconeogenesis
Galactose metabolism
Starch and sucrose metabolism
Metabolic pathways
Orthology
K01084  
glucose-6-phosphatase
Genes
HSA: 
2538(G6PC) 57818(G6PC2) 92579(G6PC3)
PTR: 
454703(G6PC) 454720(G6PC3) 741431(G6PC2)
PPS: 
GGO: 
101125519(G6PC2) 101128335(G6PC3) 101141013(G6PC)
PON: 
100446540(G6PC) 100453765(G6PC2) 100458617(G6PC3)
MCC: 
709062 712053(G6PC) 714276(G6PC3) 719987
MMU: 
14377(G6pc) 14378(G6pc2) 68401(G6pc3)
RNO: 
25634(G6pc) 303565(G6pc3) 681817
CFA: 
403492(G6PC) 488389(G6PC2) 490942(G6PC3)
AML: 
FCA: 
101085486(G6PC2) 101097770(G6PC3) 723970(G6PC)
BTA: 
369023(G6PC3) 505012(G6PC2) 538710(G6PC)
SSC: 
100134959(G6PC) 100512070 100518871
ECB: 
100052233 100062750(G6PC2) 100064862(G6PC3)
MDO: 
100011161 100022847 100619897
SHR: 
100916128(G6PC) 100925165(G6PC2) 100930187(G6PC3)
OAA: 
100083297
GGA: 
100857298 100859356 424171(G6PC2)
MGP: 
100544089 100548217
TGU: 
100219762(G6PC2) 100222678(G6PC) 101233861(G6PC)
ACS: 
100552727 100556520 100557368 100563129
XLA: 
379290(g6pc) 379852(g6pc) 398854 398855(MGC68455) 447506(g6pc2)
XTR: 
100125173(g6pc2) 100127753(g6pc) 448183(g6pc) 779477(g6pc3.1)
DRE: 
100000750(g6pcb) 445118(g6pca.1) 563180(g6pca.2) 790919(g6pc3)
TRU: 
101061994 101072756 101072977
OLA: 
101156928 101162637 101168932 101169348
BFO: 
BRAFLDRAFT_281260
SPU: 
578064 587212
DME: 
Dmel_CG15400
DPO: 
Dpse_GA13703
DAN: 
Dana_GF14918
DER: 
Dere_GG24489
DPE: 
Dper_GL15452
DSE: 
Dsec_GM18196
DSI: 
Dsim_GD22801
DWI: 
Dwil_GK24758
DYA: 
Dyak_GE15022
DGR: 
Dgri_GH25128
DVI: 
Dvir_GJ14148
AAG: 
AaeL_AAEL004295
CQU: 
CpipJ_CPIJ016653
ISC: 
IscW_ISCW017459
TSP: 
Tsp_09960
SMM: 
Smp_129450
NVE: 
NEMVE_v1g194144
HMG: 
100205966
 » show all
Taxonomy
Reference
1  [PMID:169241]
  Authors
Anchors JM, Karnovsky ML.
  Title
Purification of cerebral glucose-6-phosphatase. An enzyme involved in sleep.
  Journal
J. Biol. Chem. 250 (1975) 6408-16.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:164220]
  Authors
Colilla W, Jorgenson RA, Nordlie RC.
  Title
Mammalian carbamyl phosphate : glucose phosphotransferase and glucose-6-phosphate phosphohydrolase: extended tissue distribution.
  Journal
Biochim. Biophys. Acta. 377 (1975) 117-25.
  Organism
Rattus norvegicus [GN:rno], Bos taurus [GN:bta]
Reference
3
  Authors
Nordlie, R.C.
  Title
Glucose-6-phosphatase, hydrolytic and synthetic activities.
  Journal
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 4, Academic Press, New York, 1971, p. 543-610.
Reference
4  [PMID:4370737]
  Authors
Nordlie RC.
  Title
Metabolic regulation by multifunctional glucose-6-phosphatase.
  Journal
Curr. Top. Cell. Regul. 8 (1974) 33-117.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9001-39-2
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