KEGG   ENZYME: 3.1.3.9Help
Entry
EC 3.1.3.9                  Enzyme                                 

Name
glucose-6-phosphatase;
glucose 6-phosphate phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
D-glucose-6-phosphate phosphohydrolase
Reaction(IUBMB)
D-glucose 6-phosphate + H2O = D-glucose + phosphate [RN:R00303]
Reaction(KEGG)
Substrate
D-glucose 6-phosphate [CPD:C00092];
H2O [CPD:C00001]
Product
D-glucose [CPD:C00031];
phosphate [CPD:C00009]
Comment
Wide distribution in animal tissues. Also catalyses potent transphosphorylations from carbamoyl phosphate, hexose phosphates, diphosphate, phosphoenolpyruvate and nucleoside di- and triphosphates, to D-glucose, D-mannose, 3-methyl-D-glucose or 2-deoxy-D-glucose [cf. EC 2.7.1.62 (phosphoramidate---hexose phosphotransferase), EC 2.7.1.79 (diphosphate---glycerol phosphotransferase) and EC 3.9.1.1 (phosphoamidase)].
History
EC 3.1.3.9 created 1961
Pathway
Glycolysis / Gluconeogenesis
Galactose metabolism
Starch and sucrose metabolism
Metabolic pathways
Orthology
K01084  
glucose-6-phosphatase
Genes
HSA: 
2538(G6PC) 57818(G6PC2) 92579(G6PC3)
PTR: 
454703(G6PC) 454720(G6PC3) 741431(G6PC2)
PPS: 
GGO: 
101125519(G6PC2) 101128335(G6PC3) 101141013(G6PC)
PON: 
100446540(G6PC) 100453765(G6PC2) 100458617(G6PC3)
NLE: 
100584622(G6PC3) 100607569(G6PC) 100607735(G6PC2)
MCC: 
709062 712053(G6PC) 714276(G6PC3) 719987
MCF: 
102133548(G6PC2) 102139699(G6PC3) 102144494(G6PC)
CJC: 
100400025(G6PC3) 100400291(G6PC2) 100415213(G6PC)
MMU: 
14377(G6pc) 14378(G6pc2) 68401(G6pc3)
RNO: 
25634(G6pc) 303565(G6pc3) 681817
CGE: 
100753219(G6pc3) 100762184(G6pc2) 100763214(G6pc)
NGI: 
103735922(G6pc) 103737990(G6pc2) 103738281(G6pc3)
HGL: 
101708598(G6pc) 101715644(G6pc2) 101723886(G6pc3)
OCU: 
100303766(G6PC) 100345755(G6PC2) 100358721(G6PC3)
TUP: 
102482686(G6PC2) 102492187(G6PC) 102502251(G6PC3)
CFA: 
403492(G6PC) 488389(G6PC2) 490942(G6PC3)
AML: 
UMR: 
103659532(G6PC2) 103665582(G6PC3) 103672592(G6PC)
FCA: 
101085486(G6PC2) 101097770(G6PC3) 723970(G6PC)
PTG: 
102963963(G6PC) 102971546(G6PC2) 102972701(G6PC3)
BTA: 
369023(G6PC3) 505012(G6PC2) 538710(G6PC)
BOM: 
102275376(G6PC2) 102276125(G6PC3) 102288249(G6PC)
PHD: 
102321107(G6PC) 102327308(G6PC2) 102344089(G6PC3)
CHX: 
102170730(G6PC) 102174704(G6PC2) 102179979(G6PC3)
OAS: 
SSC: 
100134959(G6PC) 100512070(G6PC3) 100518871(G6PC2)
CFR: 
102507692(G6PC2) 102514181(G6PC) 102514670(G6PC3)
BACU: 
LVE: 
103070284(G6PC3) 103077238(G6PC) 103077901(G6PC2)
ECB: 
100052233(G6PC) 100062750(G6PC2) 100064862(G6PC3)
MYB: 
102247442(G6PC3) 102248370(G6PC2) 102253613(G6PC)
MYD: 
102759248(G6PC) 102765471(G6PC3) 102774116(G6PC2)
PALE: 
102887492(G6PC3) 102896886(G6PC2) 102898137(G6PC)
MDO: 
100011161(G6PC) 100022847(G6PC3) 100619897(G6PC2)
SHR: 
100916128(G6PC) 100925165(G6PC2) 100930187(G6PC3)
OAA: 
100083297(G6PC2) 100088723(G6PC3)
GGA: 
100857298 100859356(G6PC3) 424171(G6PC2)
MGP: 
APLA: 
101791867(G6PC) 101796993(G6PC2)
TGU: 
100219762(G6PC2) 100222678(G6PC) 101233861(G6PC)
FAB: 
101813511(G6PC) 101814845(G6PC3) 101820224(G6PC2)
PHI: 
102104187(G6PC3) 102104788(G6PC) 102112343(G6PC2)
FPG: 
101913376(G6PC2) 101914510(G6PC3) 101915055(G6PC)
FCH: 
102052041(G6PC) 102052276(G6PC2) 102056383(G6PC3)
CLV: 
102088466(G6PC) 102093779(G6PC2)
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
379290(g6pc) 379852(g6pc) 398854 398855(MGC68455) 447506(g6pc2)
XTR: 
100125173(g6pc2) 100127753(g6pc) 448183(g6pc) 779477(g6pc3.1)
DRE: 
100000750(g6pcb) 445118(g6pca.1) 563180(g6pca.2) 790919(g6pc3)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102352326(G6PC2) 102353877(G6PC3) 102366630(G6PC)
CMK: 
BFO: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DVI: 
MDE: 
AAG: 
CQU: 
BMOR: 
ISC: 
TSP: 
LGI: 
SMM: 
NVE: 
HMG: 
EHX: 
 » show all
Taxonomy
Reference
1  [PMID:169241]
  Authors
Anchors JM, Karnovsky ML.
  Title
Purification of cerebral glucose-6-phosphatase. An enzyme involved in sleep.
  Journal
J. Biol. Chem. 250 (1975) 6408-16.
Reference
2  [PMID:164220]
  Authors
Colilla W, Jorgenson RA, Nordlie RC.
  Title
Mammalian carbamyl phosphate : glucose phosphotransferase and glucose-6-phosphate phosphohydrolase: extended tissue distribution.
  Journal
Biochim. Biophys. Acta. 377 (1975) 117-25.
Reference
3
  Authors
Nordlie, R.C.
  Title
Glucose-6-phosphatase, hydrolytic and synthetic activities.
  Journal
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 4, Academic Press, New York, 1971, p. 543-610.
Reference
4  [PMID:4370737]
  Authors
Nordlie RC.
  Title
Metabolic regulation by multifunctional glucose-6-phosphatase.
  Journal
Curr. Top. Cell. Regul. 8 (1974) 33-117.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9001-39-2

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