KEGG   ENZYME: 3.1.4.1Help
Entry
EC 3.1.4.1                  Enzyme                                 
Name
phosphodiesterase I;
5'-exonuclease;
5'-phosphodiesterase;
5'-nucleotide phosphodiesterase;
oligonucleate 5'-nucleotidohydrolase;
5' nucleotide phosphodiesterase/alkaline phosphodiesterase I;
5'-NPDase;
5'-PDase;
5'-PDE;
5'NPDE;
alkaline phosphodiesterase;
nucleotide pyrophosphatase/phosphodiesterase I;
orthophosphoric diester phosphohydrolase;
PDE I;
phosphodiesterase (ambiguous);
exonuclease I
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
oligonucleotide 5'-nucleotidohydrolase
Reaction(IUBMB)
Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides
Comment
Hydrolyses both ribonucleotides and deoxyribonucleotides. Has low activity towards polynucleotides. A 3'-phosphate terminus on the substrate inhibits hydrolysis.
Orthology
K01513  
ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3
Genes
HSA: 
5167(ENPP1) 5169(ENPP3)
PTR: 
463000(ENPP3) 463002(ENPP1)
PPS: 
100973601(ENPP3) 100973949(ENPP1)
GGO: 
PON: 
100173734(ENPP3) 100434892(ENPP1)
MCC: 
710140(ENPP1) 710232(ENPP3)
MMU: 
18605(Enpp1) 209558(Enpp3)
RNO: 
54410(Enpp3) 85496(Enpp1)
CFA: 
AML: 
100463837(ENPP3) 100466346(ENPP1)
FCA: 
101094103(ENPP3) 101094350(ENPP1)
BTA: 
529405(ENPP3) 615535(ENPP1)
SSC: 
100037271(ENPP1) 100621671
ECB: 
100067583(ENPP3) 100073097(ENPP1)
MDO: 
100031034(ENPP3) 100031043(ENPP1)
SHR: 
100927611(ENPP3) 100928132(ENPP1)
OAA: 
100074336(ENPP3) 100074382
GGA: 
426928(ENPP3) 426929(ENPP1)
MGP: 
100544279
TGU: 
100219928(ENPP3) 100228551(ENPP1)
ACS: 
100562470 100562666(enpp1)
XTR: 
100422807(enpp1) 100422808(enpp3)
DRE: 
562399(enpp1)
TRU: 
101064921 101078403
OLA: 
101171013
CIN: 
100175017
SPU: 
579858
ISC: 
IscW_ISCW013243
TSP: 
Tsp_08123
NVE: 
NEMVE_v1g213276
TAD: 
TRIADDRAFT_58865
NGR: 
NAEGRDRAFT_31890 NAEGRDRAFT_63323
 » show all
Taxonomy
Reference
1
  Authors
Khorana, G.H.
  Title
Phosphodiesterases.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 5, Academic Press, New York, 1961, p. 79-94.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9025-82-5
DBGET integrated database retrieval system