| Entry |
|
|---|
| Name |
phosphoinositide phospholipase C;
triphosphoinositide phosphodiesterase;
phosphoinositidase C;
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase;
monophosphatidylinositol phosphodiesterase;
phosphatidylinositol phospholipase C;
PI-PLC;
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
inositoltrisphosphohydrolase |
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| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
 |
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| Sysname |
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate
inositoltrisphosphohydrolase |
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| Reaction(IUBMB) |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O =
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol |
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| Reaction(KEGG) |
(other) R03435
 |
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| Substrate |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637];
H2O [CPD:C00001] |
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| Product |
1D-myo-inositol 1,4,5-trisphosphate [CPD:C01245];
diacylglycerol [CPD:C00165] |
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| Comment |
These enzymes form some of the cyclic phosphate
Ins(cyclic1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity
towards phosphatidylinositol, i.e., the activity of EC 4.6.1.13,
phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+].
Four beta-isoforms regulated by G-proteins, two gamma-forms
regulated by tyrosine kinases, four delta-forms regulated at least
in part by calcium and an epsilon-form, probably regulated by the
oncogene ras, have been found. |
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| Pathway |
PATH: ec00562 Inositol phosphate metabolism
PATH: ec01100 Metabolic pathways
PATH: ec04070 Phosphatidylinositol signaling system |
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| Orthology |
KO: K01116 1-phosphatidylinositol-4,5-bisphosphate
phosphodiesterase
KO: K05857 phospholipase C, delta
KO: K05858 phospholipase C, beta
KO: K05859 phospholipase C, gamma |
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| Genes |
HSA: 113026(PLCD3) 23236(PLCB1) 5330(PLCB2) 5331(PLCB3) 5332(PLCB4)
5333(PLCD1) 5335(PLCG1) 5336(PLCG2) 84812(PLCD4)
PTR: 453330(PLCB2) 454268(PLCG2) 458093(PLCB4) 458253(PLCG1)
468279(PLCD3) 469875(PLCB1) 470647(PLCD4)
MCC: 696860(PLCD1) 697069(PLCG1) 699569(PLCD4) 701951(PLCB2)
714173(PLCG2) 715924 717764 718387
MMU: 18795(Plcb1) 18796(Plcb2) 18797(Plcb3) 18798(Plcb4)
18799(Plcd1) 18802(Plcd4) 18803(Plcg1) 234779(Plcg2)
72469(Plcd3)
RNO: 140693(Plcd4) 24654(Plcb1) 24655(Plcd1) 25031(Plcb4)
25738(Plcg1) 287745(Plcd3) 29322(Plcb3) 29337(Plcg2)
85240(Plcb2)
CFA: 476034(PLCB3) 477160(PLCB4) 478910(PLCD4) 485586(PLCD1)
485773(PLCB1) 485874(PLCG1) 487491(PLCB2) 489692(PLCG2)
490929(PLCD3)
BTA: 281985(PLCB4) 281986(PLCD1) 281987(PLCG1) 287026(PLCB1) 506171
511659 513057(PLCD3) 515669(PLCB3) 540771(PLCD4) 790012(PLCD1)
SSC: 100152679 100153085 100154302 100157641 397119(PLCD4)
ECB: 100051485 100051558 100054233(PLCD1) 100055407(PLCB3)
100055670(PLCG2) 100057315(PLCB2) 100058665 100064142 100070545
MDO: 100011291 100024144 100027579 100031660 100031869 100032696
100033281
OAA: 100076776 100078508 100083809
GGA: 415805(PLCG2) 416730(PLCB4) 420416(PLCD1) 423014(PLCB2)
427687(PLCB1)
TGU: 100219122 100219388 100221959 100222362 100229323 100229635
XLA: 397692(plc1) 398359 398360 735225(plcd4)
XTR: 780394(plcb1)
DRE: 100001532(plcb3) 100006048 100149328 337489(plcd1b)
373867(plcg1) 555443(plcd1a) 556032 561747(plcg2) 561825
565669(plcd4a) 569040(plcd3a)
BFO: BRAFLDRAFT_202613 BRAFLDRAFT_202677 BRAFLDRAFT_223817
BRAFLDRAFT_285727
CIN: 100178711 100182086 100185660 100186259
SPU: 494023(PLCd) 579102 587412
DME: Dmel_CG3620(norpA) Dmel_CG4200(sl) Dmel_CG4574(Plc21C)
DPO: Dpse_GA17564 Dpse_GA18024(Dpse_small-wing) Dpse_GA18269
DAN: Dana_GF19146 Dana_GF19456 Dana_GF20639
DER: Dere_GG17956 Dere_GG18703 Dere_GG24713
DPE: Dper_GL14297 Dper_GL15831 Dper_GL18869
DSE: Dsec_GM12340 Dsec_GM13428 Dsec_GM16735
DSI: Dsim_GD23017 Dsim_GD24832
DYA: Dyak_GE16341 Dyak_GE16747(Dyak_Plc21C) Dyak_GE17264
DGR: Dgri_GH10584 Dgri_GH12692 Dgri_GH24286
DMO: Dmoj_GI14457 Dmoj_GI16411 Dmoj_GI23110
AGA: AgaP_AGAP001936 AgaP_AGAP009115 AgaP_AGAP011152
AAG: AaeL_AAEL004431 AaeL_AAEL009380 AaeL_AAEL010124
CQU: CpipJ_CPIJ000778 CpipJ_CPIJ008193 CpipJ_CPIJ008403
AME: 408996 551139 551709
NVI: 100115054 100120894
TCA: 659062 662602
API: 100161327 100162131 100165982 100166756 100166969
ISC: IscW_ISCW001177 IscW_ISCW001178 IscW_ISCW015942 IscW_ISCW020642
CEL: B0348.4(egl-8) R05G6.8(plc-4) T01E8.3(plc-3)
CBR: CBG05896 CBG18715
BMY: Bm1_31705 Bm1_42205 Bm1_51505
SMM: Smp_146330
NVE: NEMVE_v1g101739 NEMVE_v1g114299 NEMVE_v1g124290 NEMVE_v1g136833
NEMVE_v1g174
HMG: 100198602 100200484 100212273
TAD: TRIADDRAFT_61893 TRIADDRAFT_61894
ATH: AT2G40116
POP: POPTR_803315 POPTR_805439 POPTR_815304
RCU: RCOM_0339630 RCOM_0612550 RCOM_0612560 RCOM_1398830
VVI: 100241574 100248420(GSVIVT00029292001) 100255373 100267383
OSA: 4332497(Os03g0289300) 4337686(Os05g0127200)
SBI: SORBI_01g038540(SORBIDRAFT_01g038540)
SORBI_09g002320(SORBIDRAFT_09g002320)
PPP: PHYPADRAFT_110278(PLC2) PHYPADRAFT_133245(PLC3)
PHYPADRAFT_202996(PLC4) PHYPADRAFT_216835(PLC1)
PHYPADRAFT_221032(PLC5)
CRE: CHLREDRAFT_142126
OLU: OSTLU_50249
SCE: YPL268W(PLC1)
AGO: AGOS_ACR024W
KLA: KLLA0D00638g
DHA: DEHA0A04554g
PIC: PICST_42966(PLC1)
CGR: CAGL0A01177g
YLI: YALI0C04180g
SPO: SPAC22F8.11(plc1)
MGR: MGG_02444
ANI: AN0664.2
AFM: AFUA_1G13250
AOR: AO090012000557
ANG: An08g06320
NFI: NFIA_012260
CNE: CNC04820
CNB: CNBC2360
MBR: MONBRDRAFT_21166
DDI: DDB_0201656(pipA)
PFA: PF10_0132(PI_PLC)
PYO: PY04833
TAN: TA06965
CPV: cgd4_2560
CHO: Chro.40288
TET: TTHERM_00085110
PTM: GSPATT00008002001 GSPATT00030070001 GSPATT00031253001
GSPATT00031342001
TBR: Tb11.02.3780
LMA: LmjF30.2950
LIF: LinJ30.3320
LBZ: LbrM22_V2.1590
PTI: PHATRDRAFT_42683(PLC-delta) PHATRDRAFT_bd1000
TPS: THAPS_263246
 |
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| Structures |
PDB: 1DJG 1DJH 1DJI 1DJW 1DJX 1DJY 1DJZ 1HSQ 1JAD 1MAI
1QAS 1QAT 1Y0M 1YWO 1YWP 2C5L 2EOB 2FCI 2FJL 2FJU
2HSP 2ISD 2K2J 2PLD 2PLE 2W2W 2W2X 2ZKM 3GQI |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:6275838]
Downes CP, Michell RH.
The polyphosphoinositide phosphodiesterase of erythrocyte membranes.
Biochem. J. 198 (1981) 133-40.
Homo sapiens [GN:hsa], Rattus norvegicus [GN:rno], Oryctolagus
cuniculus |
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Reference
Authors
Title
Journal
|
2
Thompson, W. and Dawson, R.M.C.
The triphosphoinositide phosphodiesterase of brain tissue.
Biochem. J. 91 (1964) 237-243. |
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Reference
Authors
Title
Journal
Organism
|
3 [PMID:9182519]
Rhee SG, Bae YS.
Regulation of phosphoinositide-specific phospholipase C isozymes.
J. Biol. Chem. 272 (1997) 15045-8.
mammalian |
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| Other DBs |
ExplorEnz - The Enzyme Database: 3.1.4.11
IUBMB Enzyme Nomenclature: 3.1.4.11
ExPASy - ENZYME nomenclature database: 3.1.4.11
BRENDA, the Enzyme Database: 3.1.4.11
CAS: 63551-76-8 |
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