KEGG   ENZYME: 3.1.4.12Help
Entry
EC 3.1.4.12                 Enzyme                                 
Name sphingomyelin phosphodiesterase;
neutral sphingomyelinase
Class Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname sphingomyelin cholinephosphohydrolase
Reaction(IUBMB) sphingomyelin + H2O = N-acylsphingosine + choline phosphate
[RN:R02541]
Reaction(KEGG) R02541
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Substrate sphingomyelin [CPD:C00550];
H2O [CPD:C00001]
Product N-acylsphingosine [CPD:C00195];
choline phosphate [CPD:C00588]
Comment Has very little activity on phosphatidylcholine.
Pathway PATH: ec00600  Sphingolipid metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01117  sphingomyelin phosphodiesterase
KO: K12350  sphingomyelin phosphodiesterase
KO: K12351  sphingomyelin phosphodiesterase 2
KO: K12352  sphingomyelin phosphodiesterase 3
KO: K12353  sphingomyelin phosphodiesterase 4
KO: K12354  ectonucleotide pyrophosphatase/phosphodiesterase family
            member 7
Genes HSA: 339221(ENPP7) 55512(SMPD3) 55627(SMPD4) 6609(SMPD1) 6610(SMPD2)
PTR: 450990(SMPD1) 462928(SMPD2) 468008(SMPD3)
MCC: 698865(SMPD2) 703384(SMPD3) 710812 711248(SMPD1) 717416(ENPP7)
MMU: 100046038 20597(Smpd1) 20598(Smpd2) 238011(Enpp7) 58994(Smpd3)
     77626(Smpd4)
RNO: 303729(Enpp7) 303790(Smpd4) 308909(Smpd1) 315091(RGD1565316)
     83537(Smpd2) 94338(Smpd3)
CFA: 479858 481957(SMPD2) 485334(SMPD1) 486434(SMPD4) 489743(SMPD3)
     608627(ENPP7)
BTA: 505097(SMPD1) 507207(SMPD4) 509018(SMPD2) 514201(SMPD3) 521021
SSC: 100152155 100152725
ECB: 100052086(SMPD4) 100066652 100066707 100069949
MDO: 100022732 100026609 100029088 100030863 100030901
OAA: 100079000 100086736 100091167 100091635
GGA: 415619(SMPD3) 416942(SMPD4) 426249(ENPP7) 770663(SMPD2)
TGU: 100220177 100225712 100226949 100227648
XLA: 495009(smpd4) 734723
XTR: 100127861 100145256
DRE: 100147898(CH73-316N6.2) 100150230 556700 557756 557817
     567548(smpd2) 567592 568381(smpd3) 569930 793294(smpd4) 797914
BFO: BRAFLDRAFT_217983 BRAFLDRAFT_218091 BRAFLDRAFT_275713
     BRAFLDRAFT_61294
CIN: 100183403 100184183 100185767 494378
SPU: 576943 577518 578923 590197 752817
DME: Dmel_CG12034 Dmel_CG3376 Dmel_CG6962
DPO: Dpse_GA17413 Dpse_GA19987
DAN: Dana_GF11387 Dana_GF23059
DER: Dere_GG17183 Dere_GG22956
DPE: Dper_GL12365 Dper_GL20005
DSE: Dsec_GM11849 Dsec_GM26063
DSI: Dsim_GD11848 Dsim_GD20627
DYA: Dyak_GE10077 Dyak_GE14393
DGR: Dgri_GH18779 Dgri_GH20981
DMO: Dmoj_GI21317 Dmoj_GI22670
AGA: AgaP_AGAP000405 AgaP_AGAP008053 AgaP_AGAP011940
AAG: AaeL_AAEL002009 AaeL_AAEL002910 AaeL_AAEL003402
CQU: CpipJ_CPIJ002610 CpipJ_CPIJ005541 CpipJ_CPIJ010127
AME: 409437 412170 551484
NVI: 100116205 100118365 100123169
TCA: 654894 659870 663944 664240
API: 100165015 100166116 100169137
ISC: IscW_ISCW003399 IscW_ISCW012388 IscW_ISCW018870
CEL: B0252.2(asm-1) R05D11.9 T27F6.6 W03G1.7(asm-3) ZK455.4(asm-2)
CBR: CBG01606 CBG11183 CBG12510 CBG17365
BMY: Bm1_17210 Bm1_54240
SMM: Smp_104600.1 Smp_104600.2
NVE: NEMVE_v1g105071 NEMVE_v1g239044 NEMVE_v1g243970 NEMVE_v1g40552
HMG: 100199168
TAD: TRIADDRAFT_30983 TRIADDRAFT_62319
SBI: SORBI_01g050550(SORBIDRAFT_01g050550)
ZMA: 100279889(gpm923)
PPP: PHYPADRAFT_156144
CRE: CHLREDRAFT_168092
PIC: PICST_51970(IFP3)
FGR: FG07002.1
AFM: AFUA_4G06640
AOR: AO090023000919
AFV: AFLA_113270
PCS: Pc22g17620
NFI: NFIA_109550
SSL: SS1G_09965
BFU: BC1G_07278
LBC: LACBIDRAFT_235422
DDI: DDB_0232049(sgmB)
EHI: EHI_007460 EHI_088080 EHI_118110 EHI_193190
TAN: TA09680
TPV: TP01_1199
TET: TTHERM_01054320
PTM: GSPATT00002310001 GSPATT00016233001
BAN: BA0678(sph)
BAR: GBAA0678(sph)
BAT: BAS0644
BCE: BC0671
BCA: BCE_0745(sph)
BCZ: BCZK0589(sph)
BTK: BT9727_0588(sph)
BTL: BALH_0618(sph)
STP: Strop_2045
LIL: LA1027(sph1) LA1029(sph2) LA3540(sphH) LA4004(sph3)
LIC: LIC12631 LIC12632 LIC13198
LBJ: LBJ_0291
LBL: LBL_2785
SYP: SYNPCC7002_A2848(sph)
Taxonomy
Structures PDB: 1ZWX  2DDR  2DDS  2DDT  2UYR  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:5916388]
Barnholz Y, Roitman A, Gatt S.
Enzymatic hydrolysis of sphingolipids. II. Hydrolysis of
sphingomyelin by an enzyme from rat brain.
J. Biol. Chem. 241 (1966) 3731-7.
Rattus norvegicus [GN:rno]
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:2545711]
Chatterjee S, Ghosh N.
Neutral sphingomyelinase from human urine. Purification and
preparation of monospecific antibodies.
J. Biol. Chem. 264 (1989) 12554-61.
Homo sapiens [GN:hsa]
Reference
  Authors
  Title
  Journal
  Organism
 3  [PMID:5911524]
Heller M, Shapiro B.
Enzymic hydrolysis of sphingomyelin by rat liver.
Biochem. J. 98 (1966) 763-9.
Rattus norvegicus [GN:rno]
Reference
  Authors
  Title

  Journal
  Organism
 4  [PMID:5933867]
Kanfer JN, Young OM, Shapiro D, Brady RO.
The metabolism of sphingomyelin. I. Purification and properties of a
sphingomyelin-cleaving enzyme from rat liver tissue.
J. Biol. Chem. 241 (1966) 1081-4.
Rattus norvegicus [GN:rno]
Other DBs ExplorEnz - The Enzyme Database: 3.1.4.12
IUBMB Enzyme Nomenclature: 3.1.4.12
ExPASy - ENZYME nomenclature database: 3.1.4.12
BRENDA, the Enzyme Database: 3.1.4.12
CAS: 9031-54-3
DBGET integrated database retrieval system