KEGG   ENZYME: 3.1.4.12Help
Entry
EC 3.1.4.12                 Enzyme                                 
Name
sphingomyelin phosphodiesterase;
neutral sphingomyelinase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
sphingomyelin cholinephosphohydrolase
Reaction(IUBMB)
a sphingomyelin + H2O = a ceramide + phosphocholine [RN:R02541]
Reaction(KEGG)
Substrate
sphingomyelin [CPD:C00550];
H2O [CPD:C00001]
Product
ceramide [CPD:C00195];
phosphocholine [CPD:C00588]
Comment
Has very little activity on phosphatidylcholine.
Pathway
Sphingolipid metabolism
Metabolic pathways
Orthology
K01117  
sphingomyelin phosphodiesterase
K12350  
sphingomyelin phosphodiesterase
K12351  
sphingomyelin phosphodiesterase 2
K12352  
sphingomyelin phosphodiesterase 3
K12353  
sphingomyelin phosphodiesterase 4
K12354  
ectonucleotide pyrophosphatase/phosphodiesterase family member 7
Genes
HSA: 
339221(ENPP7) 55512(SMPD3) 55627(SMPD4) 6609(SMPD1) 6610(SMPD2)
PTR: 
450990(SMPD1) 459619(SMPD4) 462928(SMPD2) 468008(SMPD3) 742055(ENPP7)
PPS: 
100970699(SMPD2) 100972160(ENPP7) 100983093 100985758(SMPD3) 100994517(SMPD1)
GGO: 
101128835(SMPD2) 101145060(ENPP7) 101145253(SMPD1)
PON: 
100172518(SMPD1) 100174043(SMPD4) 100435456(SMPD3) 100455395(SMPD2) 100455485(ENPP7)
MCC: 
698865(SMPD2) 703384(SMPD3) 711248(SMPD1) 717416(ENPP7) 718018(SMPD4)
MMU: 
20597(Smpd1) 20598(Smpd2) 238011(Enpp7) 58994(Smpd3) 77626(Smpd4)
RNO: 
303729(Enpp7) 303790(Smpd4) 308909(Smpd1) 83537(Smpd2) 94338(Smpd3)
CFA: 
100855615 485334(SMPD1) 486434(SMPD4) 489743(SMPD3) 608627(ENPP7)
AML: 
FCA: 
101082570(SMPD2) 101085334(ENPP7) 101091244 101094390(SMPD3) 101099497(SMPD1) 101100196(SMPD4)
BTA: 
505097(SMPD1) 505388 507207(SMPD4) 509018(SMPD2) 514201(SMPD3) 521021
SSC: 
100152155 100152725(SMPD4) 100514726(ENPP7) 100518128 100518980(SMPD1)
ECB: 
100052086(SMPD4) 100066652 100069949
MDO: 
100022732(SMPD3) 100025584(SMPD4) 100026609 100029088 100030863(SMPD1) 100030901(ENPP7)
SHR: 
100915511(ENPP7) 100916633(SMPD1) 100917993(SMPD3) 100923932 100934158
OAA: 
100074176 100079000(SMPD4) 100086736 100087213 100091167 100091635
GGA: 
415619(SMPD3) 416942(SMPD4) 419077(SMPD1) 426249(ENPP7) 770663(SMPD2)
MGP: 
100539218(SMPD4) 100544613
TGU: 
100225712(SMPD4) 100226949(ENPP7) 100227648(SMPD3)
ACS: 
100552784 100555572 100560692 100561467 100562803 100564529
XLA: 
495009(smpd4) 734723(smpd3)
XTR: 
100127861(smpd4) 100145256(smpd2) 100422804(enpp7) 100487433 100495702 100498586
DRE: 
100334069(enpp7) 100334149 556700 557756 557817 567548(smpd2) 567592(smpd5) 568381(smpd3) 569930(si:ch211-225l4.2) 793294(smpd4) 797914
TRU: 
101061586 101064377 101066148 101069341 101073134 101075111 101079664
OLA: 
101160838 101161548 101166003 101168943 101170408 101173468 101174765
BFO: 
BRAFLDRAFT_128365 BRAFLDRAFT_215923 BRAFLDRAFT_217983 BRAFLDRAFT_218091 BRAFLDRAFT_275713 BRAFLDRAFT_61294
CIN: 
100183403 100184183 100184529 100185767 494378
SPU: 
576943 577518 578923 590197 752817
DME: 
Dmel_CG12034 Dmel_CG3376 Dmel_CG6962
DPO: 
Dpse_GA11353 Dpse_GA17413 Dpse_GA19987
DAN: 
Dana_GF11387 Dana_GF23059
DER: 
Dere_GG17183 Dere_GG22956
DPE: 
Dper_GL12365 Dper_GL20005
DSE: 
Dsec_GM11849 Dsec_GM26063
DSI: 
Dsim_GD11848 Dsim_GD13741 Dsim_GD20627
DWI: 
Dwil_GK14473 Dwil_GK22200
DYA: 
Dyak_GE10077 Dyak_GE14393
DGR: 
Dgri_GH18779 Dgri_GH20981
DMO: 
Dmoj_GI21317 Dmoj_GI22670
DVI: 
Dvir_GJ21587 Dvir_GJ23398
AGA: 
AgaP_AGAP000405 AgaP_AGAP008053 AgaP_AGAP011940
AAG: 
AaeL_AAEL002009 AaeL_AAEL002910 AaeL_AAEL003402
CQU: 
CpipJ_CPIJ002610 CpipJ_CPIJ005541 CpipJ_CPIJ010127
AME: 
412170 551484 727146
NVI: 
100116205(NV15205) 100118365(NV15533) 100123169(NV11257)
TCA: 
654894 659870 663944 664240
API: 
100165015 100166116 100169137
PHU: 
Phum_PHUM122240 Phum_PHUM427830 Phum_PHUM556420
ISC: 
IscW_ISCW003399 IscW_ISCW010094 IscW_ISCW012388 IscW_ISCW018870
CEL: 
CELE_B0252.2(asm-1) CELE_R05D11.9(R05D11.9) CELE_T27F6.6(T27F6.6) CELE_W03G1.7(asm-3) CELE_ZK455.4(asm-2)
CBR: 
CBG01606(Cbr-asm-3) CBG11183(Cbr-asm-1) CBG12510 CBG17365(Cbr-asm-2) CBG23668
BMY: 
Bm1_17210 Bm1_54240
TSP: 
Tsp_02265 Tsp_02761
SMM: 
Smp_104600.1 Smp_162880
NVE: 
NEMVE_v1g105071 NEMVE_v1g239044 NEMVE_v1g243970 NEMVE_v1g40552
HMG: 
100199168
TAD: 
TRIADDRAFT_30983 TRIADDRAFT_62319
AQU: 
100632675 100633181
VCN: 
VOLCADRAFT_106613
PIC: 
PICST_51970(IFP3)
TTT: 
THITE_2116556
FGR: 
FG07002.1
NHE: 
NECHADRAFT_48714
SSL: 
SS1G_09965
BFU: 
BC1G_07278
NFI: 
NFIA_109550
AFM: 
AFUA_4G06640
AOR: 
AOR_1_1620144(AO090023000919)
ANG: 
ANI_1_1578094(An11g00670)
AFV: 
AFLA_113270
PCS: 
Pc22g17620
LBC: 
LACBIDRAFT_235422
CCI: 
CC1G_02835 CC1G_02845 CC1G_07717
PGR: 
PGTG_15615
NGR: 
NAEGRDRAFT_58659
DDI: 
DDB_G0293210(sgmB)
DPP: 
DICPUDRAFT_158024
EHI: 
EHI_007460(427.t00005) EHI_040600(164.t00014) EHI_088080(539.t00001) EHI_118110(18.t00042) EHI_193190(43.t00036)
EDI: 
EDI_013530 EDI_206790
TAN: 
TA09680
TPV: 
TP01_1199
TET: 
TTHERM_01054320
PTM: 
GSPATT00002310001 GSPATT00016233001 GSPATT00019079001
PIF: 
PITG_17987
BAN: 
BA_0678(spH)
BAR: 
GBAA_0678(spH)
BAT: 
BAS0644
BAH: 
BAMEG_3908(sph)
BAI: 
BAA_0761(sph)
BAL: 
BACI_c06860(spH)
BCE: 
BC0671
BCA: 
BCE_0745(spH)
BCZ: 
BCZK0589(spH)
BCR: 
BCAH187_A0805(sph)
BCB: 
BCB4264_A0708(sph)
BCU: 
BCAH820_0733(sph)
BCG: 
BCG9842_B4628(sph)
BCQ: 
BCQ_0745(spH)
BCX: 
BCA_0714(sph)
BCY: 
Bcer98_0568
BTK: 
BT9727_0588(spH)
BTL: 
BALH_0618(spH)
BTB: 
BMB171_C0590(sph)
BWE: 
BcerKBAB4_0592
SGR: 
SGR_1091
STP: 
Strop_2045
SAQ: 
Sare_2087
SNG: 
SNE_A21560(smcL)
LIL: 
LA_1027 LA_1029 LA_3540 LA_4004
LIC: 
LIC12631 LIC12632 LIC13198
LBJ: 
LBJ_0291
LBL: 
LBL_2785
SYP: 
SYNPCC7002_A2848(sph)
 » show all
Taxonomy
Reference
1  [PMID:5916388]
  Authors
Barnholz Y, Roitman A, Gatt S.
  Title
Enzymatic hydrolysis of sphingolipids. II. Hydrolysis of sphingomyelin by an enzyme from rat brain.
  Journal
J. Biol. Chem. 241 (1966) 3731-7.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:2545711]
  Authors
Chatterjee S, Ghosh N.
  Title
Neutral sphingomyelinase from human urine. Purification and preparation of monospecific antibodies.
  Journal
J. Biol. Chem. 264 (1989) 12554-61.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:5911524]
  Authors
Heller M, Shapiro B.
  Title
Enzymic hydrolysis of sphingomyelin by rat liver.
  Journal
Biochem. J. 98 (1966) 763-9.
  Organism
Rattus norvegicus [GN:rno]
Reference
4  [PMID:5933867]
  Authors
Kanfer JN, Young OM, Shapiro D, Brady RO.
  Title
The metabolism of sphingomyelin. I. Purification and properties of a sphingomyelin-cleaving enzyme from rat liver tissue.
  Journal
J. Biol. Chem. 241 (1966) 1081-4.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9031-54-3
DBGET integrated database retrieval system