KEGG   ENZYME: 3.1.4.14Help
Entry
EC 3.1.4.14                 Enzyme                                 
Name [acyl-carrier-protein] phosphodiesterase;
ACP hydrolyase;
ACP phosphodiesterase;
AcpH;
[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase;
holo-[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase
Class Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname holo-[acyl-carrier protein] 4'-pantetheine-phosphohydrolase
Reaction(IUBMB) holo-[acyl-carrier protein] + H2O = 4'-phosphopantetheine +
apo-[acyl-carrier protein] [RN:R01623]
Reaction(KEGG) R01623
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Substrate holo-[acyl-carrier protein] [CPD:C00229];
H2O [CPD:C00001]
Product 4'-phosphopantetheine [CPD:C01134];
apo-[acyl-carrier protein]
Comment The enzyme cleaves acyl-[acyl-carrier-protein] species with acyl
chains of 6-16 carbon atoms although it appears to demonstrate a
preference for the unacylated acyl-carrier protein (ACP) and
short-chain ACPs over the medium- and long-chain species [3].
Deletion of the gene encoding this enzyme abolishes ACP
prosthetic-group turnover in vivo [3]. Activation of apo-ACP to form
the holoenzyme is carried out by EC 2.7.8.7,
holo-[acyl-carrier-protein] synthase.
Pathway PATH: ec00770  Pantothenate and CoA biosynthesis
Orthology KO: K08682  acyl carrier protein phosphodiesterase
Genes ECO: b0404(acpH)
ECJ: JW0394(yajB)
ECD: ECDH10B_0360(acpH)
EBW: BWG_0286(acpH)
ECE: Z0503(yajB)
ECS: ECs0455
ECF: ECH74115_0484(acpH)
ETW: ECSP_0469(acpH)
ECG: E2348C_0339(acpH)
ECC: c0514(yajB)
ECI: UTI89_C0426(yajB)
ECP: ECP_0463
ECV: APECO1_1606(yajB)
ECW: EcE24377A_0434(acpH)
ECX: EcHS_A0474(acpH)
ECM: EcSMS35_0436(acpH)
ECY: ECSE_0425
ECL: EcolC_3229
ECK: EC55989_0413(acpH)
ECQ: ECED1_0427(acpH)
ECR: ECIAI1_0404(acpH)
ECT: ECIAI39_0277(acpH)
ECZ: ECS88_0399(acpH)
EUM: ECUMN_0442(acpH)
ELF: LF82_0020(acpH)
EBL: B21_00356(yajB)
EBD: ECBD_3257
EOH: ECO103_0378(yajB)
EOI: ECO111_0434(yajB)
EOJ: ECO26_0436(yajB)
EFE: EFER_2621(acpH)
STY: STY0441(yajB)
STT: t2460(yajB)
SPT: SPA2320(yajB)
SEK: SSPA2163
SPQ: SPAB_03184
SEI: SPC_0414(yajB)
SEC: SC0445(yajB)
SEH: SeHA_C0503(acpH)
SEE: SNSL254_A0448(acpH)
SEW: SeSA_A0461(acpH)
SEA: SeAg_B0442(acpH)
SED: SeD_A0443(acpH)
SEG: SG0415(yajB)
SET: SEN0386(yajB)
SES: SARI_02522
STM: STM0403(yajB)
YPE: YPO3193
YPK: y0989
YPM: YP_0738
YPA: YPA_2688
YPN: YPN_0894
YPG: YpAngola_A3386(acpH)
YPP: YPDSF_2828
YPS: YPTB0926(yajB)
YPI: YpsIP31758_3125(acpH)
YPY: YPK_3266
YPB: YPTS_0967
YEN: YE3173
SFL: SF0341(yajB)
SSN: SSON_0381(yajB)
SBO: SBO_0298(yajB)
SBC: SbBS512_E0323(acpH)
SDY: SDY_0330(yajB)
ECA: ECA1118
PCT: PC1_1017
PWA: Pecwa_3293
ETA: ETA_25410(acpH)
PLU: plu3906
PAY: PAU_03492
SGL: SG0644
ENT: Ent638_0873
ESA: ESA_02898
CTU: Ctu_09820(acpH)
KPN: KPN_00355(yajB)
KPE: KPK_4330(acpH)
KPU: KP1_1219(yajB)
CKO: CKO_02757
SPE: Spro_1059
PMR: PMI0074
EIC: NT01EI_1037
ETR: ETAE_0957
DDA: Dd703_2908
DDC: Dd586_1001
DZE: Dd1591_3099
APA: APP7_1254
VCH: VCA0769
VCO: VC0395_0710
VCM: VCM66_A0728
VCJ: VCD_000551
VVU: VV2_0226
VVY: VVA0730
VPA: VPA0844
VHA: VIBHAR_05934
VSP: VS_II0800
VEX: VEA_000200
PPR: PBPRA0739
PIN: Ping_3540
MMW: Mmwyl1_1687
Taxonomy
Structures PDB: 1T5B  1TIK  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:224058]
Sobhy C.
Regulation of fatty acid synthetase activity. The
4'-phosphopantetheine hydrolase of rat liver.
J. Biol. Chem. 254 (1979) 8561-6.
Rattus norvegicus [GN:rno]
Reference
  Authors
  Title
  Journal
  Organism
 2  [PMID:4290442]
Vagelos PR, Larrabes AR.
Acyl carrier protein. IX. Acyl carrier protein hydrolase.
J. Biol. Chem. 242 (1967) 1776-81.
Escherichia coli [GN:eco], Clostridium bufyricum
Reference
  Authors
  Title

  Journal
  Organism
 3  [PMID:16107329]
Thomas J, Cronan JE.
The enigmatic acyl carrier protein phosphodiesterase of Escherichia
coli: genetic and enzymological characterization.
J. Biol. Chem. 280 (2005) 34675-83.
Escherichia coli [GN:eco]
Other DBs ExplorEnz - The Enzyme Database: 3.1.4.14
IUBMB Enzyme Nomenclature: 3.1.4.14
ExPASy - ENZYME nomenclature database: 3.1.4.14
BRENDA, the Enzyme Database: 3.1.4.14
CAS: 37288-21-4
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