| Entry |
|
|---|
| Name |
phospholipase C;
lipophosphodiesterase I;
lecithinase C;
Clostridium welchii alpha-toxin;
Clostridium oedematiens beta- and gamma-toxins;
lipophosphodiesterase C;
phosphatidase C;
heat-labile hemolysin;
alpha-toxin |
|---|
| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
 |
|---|
| Sysname |
phosphatidylcholine cholinephosphohydrolase |
|---|
| Reaction(IUBMB) |
a phosphatidylcholine + H2O = 1,2-diacyl-sn-glycerol + choline
phosphate [RN:R01312] |
|---|
| Reaction(KEGG) |
R01312;
(other) R02027 R02052 R03332 R07381
 |
|---|
| Substrate |
phosphatidylcholine [CPD:C00157];
H2O [CPD:C00001] |
|---|
| Product |
1,2-diacyl-sn-glycerol [CPD:C00641];
choline phosphate [CPD:C00588] |
|---|
| Cofactor |
Zinc [CPD:C00038] |
|---|
| Comment |
The bacterial enzyme, which is a zinc protein, also acts on
sphingomyelin and phosphatidylinositol; that from seminal plasma
does not act on phosphatidylinositol. |
|---|
| Pathway |
PATH: ec00562 Inositol phosphate metabolism
PATH: ec00564 Glycerophospholipid metabolism
PATH: ec00565 Ether lipid metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01114 phospholipase C |
|---|
| Genes |
ATH: AT1G07230 AT2G26870 AT3G03530(NPC4)
POP: POPTR_570272 POPTR_571365 POPTR_641078 POPTR_666682
POPTR_829693 POPTR_878745
RCU: RCOM_0612060 RCOM_1477980 RCOM_1505800 RCOM_1516850
RCOM_1876560
VVI: 100244850 100250203 100253773 100267995
OSA: 4325407(Os01g0955000) 4334815(Os03g0852800)
SBI: SORBI_01g000860(SORBIDRAFT_01g000860)
SORBI_01g002750(SORBIDRAFT_01g002750)
SORBI_03g046200(SORBIDRAFT_03g046200)
ZMA: 100280012 100285723
PPP: PHYPADRAFT_145030 PHYPADRAFT_145448 PHYPADRAFT_180895
FGR: FG11236.1
ANI: AN2336.2 AN7691.2 AN8546.2
AFM: AFUA_1G17590 AFUA_3G01530 AFUA_7G04910
AOR: AO090005001097 AO090012000083 AO090103000073
ANG: An01g11130 An01g14940 An13g03600
AFV: AFLA_011560 AFLA_013680 AFLA_083420
PCS: Pc13g04700 Pc14g00170 Pc15g01880
NFI: NFIA_002510 NFIA_007800 NFIA_025880
CIM: CIMG_00518
URE: UREG_00545
SSL: SS1G_00272
BFU: BC1G_00879
MGL: MGL_1067 MGL_3075 MGL_3076 MGL_3326
PFA: PF10_0132(PI_PLC)
TET: TTHERM_00417920 TTHERM_00417930 TTHERM_00417940 TTHERM_00467860
TTHERM_02563200
SPE: Spro_4198
XCC: XCC0947 XCC3037(plcN)
XCB: XC_1121 XC_3288
XCA: xccb100_1159 xccb100_3406
XCV: XCV1054(phlN1) XCV3291(phlN2)
XAC: XAC1024 XAC3160(plcN)
XOO: XOO1651(plcN) XOO3682
XOM: XOO_1535 XOO_3479
XOP: PXO_01545 PXO_02511
SML: Smlt1755(plcN1)
SMT: Smal_1494
PAE: PA0844(plcH) PA3319(plcN)
PAU: PA14_21110(plcN) PA14_53360(plcH)
PAP: PSPA7_1801 PSPA7_4676
PAG: PLES_17461(plcN) PLES_44741(plcH)
PFL: PFL_3126(plcB)
ACB: A1S_0043 A1S_2055
ABM: ABSDF0054(plc) ABSDF2207(plc)
ABY: ABAYE1520(plc) ABAYE3825(plc)
ABC: ACICU_00064 ACICU_02247
ABN: AB57_0084 AB57_2376
ABB: ABBFA_001421 ABBFA_003467
SAZ: Sama_0115
ILO: IL2595(plcC)
FTU: FTT_0221(acpA)
FTF: FTF0221(acpA)
FTW: FTW_1838
FTL: FTL_0158
FTA: FTA_0172
FTM: FTM_1599
FTN: FTN_0090
FPH: Fphi_0739
AFE: Lferr_1914
AFR: AFE_2267
CVI: CV_0909(plcN)
RSO: RSc0319(plcN)
RPI: Rpic_0175 Rpic_3050 Rpic_4613
RPF: Rpic12D_0182 Rpic12D_2640 Rpic12D_3537
REU: Reut_B4287
REH: H16_A2724(plcN1) H16_B0534(plcN2) H16_B1067(plcN3)
H16_B1166(plcN4)
RME: Rmet_4192 Rmet_4624
CTI: RALTA_A2216(plcN1) RALTA_B0343(plcN2) RALTA_B1069(plcN3)
BMA: BMA0584 BMA0886 BMA1268 BMAA0079 BMAA0611 BMAA0968
BMV: BMASAVP1_0411 BMASAVP1_1239(plcN) BMASAVP1_A1411 BMASAVP1_A1756
BMASAVP1_A3463(acpA)
BML: BMA10229_0230 BMA10229_0856 BMA10229_1520 BMA10229_A0140
BMA10229_A0466 BMA10229_A1655(acpA) BMA10229_A2858
BMN: BMA10247_0693 BMA10247_1027 BMA10247_1743(plcN-2)
BMA10247_A0095(plcN) BMA10247_A1368 BMA10247_A1822
BPS: BPSL0338(plcN2) BPSL1876 BPSL2018 BPSL2403(plcN) BPSS0067
BPSS1312
BPM: BURPS1710b_0549 BURPS1710b_1804 BURPS1710b_1966
BURPS1710b_2865(plcN) BURPS1710b_A0331 BURPS1710b_A1577(plcN)
BURPS1710b_A2344(acpA)
BPL: BURPS1106A_0372(plcN) BURPS1106A_1648(acpA) BURPS1106A_1812
BURPS1106A_2804(plcN) BURPS1106A_A0091 BURPS1106A_A1043
BURPS1106A_A1778
BPD: BURPS668_0358(plcN) BURPS668_1627(acpA) BURPS668_1792
BURPS668_2745(plcN) BURPS668_A0114(plcN) BURPS668_A1863
BPR: GBP346_A0278 GBP346_A1832 GBP346_A2924
BTE: BTH_I0317(plcN) BTH_I1762 BTH_I2671 BTH_II0078 BTH_II1106
BTH_II1636
BVI: Bcep1808_1084 Bcep1808_1365 Bcep1808_3044 Bcep1808_3698
Bcep1808_4878 Bcep1808_4995
BUR: Bcep18194_A4278 Bcep18194_A4545 Bcep18194_A6306 Bcep18194_A6500
Bcep18194_B0123 Bcep18194_B0302 Bcep18194_B0428 Bcep18194_B1454
Bcep18194_B1519 Bcep18194_B1674 Bcep18194_B2801 Bcep18194_C7529
BCN: Bcen_0687 Bcen_2532 Bcen_3132 Bcen_3906 Bcen_4021 Bcen_5326
BCH: Bcen2424_1166 Bcen2424_3145 Bcen2424_4345 Bcen2424_4462
Bcen2424_5235 Bcen2424_5534
BCM: Bcenmc03_1142 Bcenmc03_3165 Bcenmc03_4738 Bcenmc03_5037
Bcenmc03_5840 Bcenmc03_6008 Bcenmc03_6410
BCJ: BCAL0443 BCAL1046(plcN) BCAM0408 BCAM1474 BCAM2429 BCAM2720
BAM: Bamb_1045 Bamb_1278 Bamb_3003 Bamb_3198 Bamb_3755 Bamb_4858
Bamb_5381
BAC: BamMC406_1048 BamMC406_2866 BamMC406_3083 BamMC406_3544
BamMC406_4229 BamMC406_5405
BMU: Bmul_1914 Bmul_2139 Bmul_2951 Bmul_3271 Bmul_4272 Bmul_6095
BMJ: BMULJ_00283(plcC) BMULJ_01106(plcC) BMULJ_01327(plcC)
BMULJ_04234(plcC) BMULJ_05254(plcC) BMULJ_05436
BXE: Bxe_A0663 Bxe_A1301 Bxe_A1415 Bxe_A2871 Bxe_B0211
BPH: Bphy_1546 Bphy_3755 Bphy_5529 Bphy_6939 Bphy_7067
BPY: Bphyt_2708 Bphyt_4267 Bphyt_5018 Bphyt_5185 Bphyt_5961
Bphyt_7094
BGL: bglu_1g09960 bglu_1g18300 bglu_2g09650 bglu_2g12540
bglu_2g19970
BPE: BP2337
BPA: BPP1702
BBR: BB3406
BAV: BAV1084(plcN1) BAV1803(plcN2)
RFR: Rfer_3735 Rfer_3736
AAV: Aave_0219 Aave_1377
VAP: Vapar_0881 Vapar_1068
CTT: CtCNB1_4380
ANK: AnaeK_3323
SCL: sce3773 sce6979(phlC2) sce7154(phlC1)
HOH: Hoch_4899
ARA: Arad_3908
AVI: Avi_2739 Avi_3801
RLE: pRL110285
BRA: BRADO5754(plcN) BRADO6351
BBT: BBta_1163(plcN) BBta_1275 BBta_6264(plcN)
BID: Bind_0014 Bind_1837 Bind_3104 Bind_3617
CCR: CC_3031
CCS: CCNA_03126
CAK: Caul_2987 Caul_2997
NAR: Saro_1552
GOX: GOX2176
ACR: Acry_3054
GDI: GDI_2475(plcA) GDI_2477(plcN)
GDJ: Gdia_0722 Gdia_0724
APT: APA01_15180
BAN: BA0677(plc)
BAR: GBAA0677(plc)
BAA: BA_1264
BAT: BAS0643
BAH: BAMEG_3909(plc)
BAI: BAA_0760(plc)
BCE: BC0670
BCA: BCE_0744(plc)
BCZ: BCZK0588(plc)
BCR: BCAH187_A0804(plc)
BCB: BCB4264_A0707(plc)
BCU: BCAH820_0732(plc)
BCG: BCG9842_B4629(plc)
BCQ: BCQ_0743(plc)
BCX: BCA_0713(plc)
BCY: Bcer98_0567
BTK: BT9727_0587(plc)
BTL: BALH_0617(plc)
BWE: BcerKBAB4_0591
SAU: SA1811(hlb)
SAV: SAV2003(truncated-hlb)
SAW: SAHV_1989
SAM: MW1940(hlb)
SAC: SACOL2003(hlb)
SAB: SAB1874
SAA: SAUSA300_1973
SAO: SAOUHSC_02240
SAJ: SaurJH9_2061
SAH: SaurJH1_2098
SAE: NWMN_1926
SAD: SAAV_2071(hlb)
SEP: SE0008
SER: SERP2544(hlb)
LMO: lmo0205(plcB)
LMF: LMOf2365_0216(plcB)
LMH: LMHCC_2438
LMC: Lm4b_00203(plcB)
AAC: Aaci_1827
CAC: CAC1019 CA_P0148(phlC)
CPE: CPE0036(plc)
CPF: CPF_0042(plc)
CPR: CPR_0041(plc)
CTC: CTC00990
CNO: NT01CX_0979 NT01CX_1638
CTH: Cthe_3193
CBO: CBO2632
CBA: CLB_2576
CBH: CLC_2507
CBY: CLM_2998
CBL: CLK_2020
CBK: CLL_A2118
CBB: CLD_1931
CBI: CLJ_B2864
CBF: CLI_2699
CKL: CKL_1485
CKR: CKR_1379
AMT: Amet_0549
PTH: PTH_1370
HMO: HM1_3138
MTU: Rv1755c(plcD) Rv2349c(plcC) Rv2350c(plcB) Rv2351c(plcA)
MTC: MT1799 MT2414 MT2415 MT2416
MRA: MRA_1766(plcD) MRA_2369(plcC) MRA_2370(plcB) MRA_2371(plcA)
MTF: TBFG_11775 TBFG_12373 TBFG_12374 TBFG_12375
MTB: TBMG_01627(TBMG_01627.1) TBMG_01628(TBMG_01628.1)
TBMG_01629(TBMG_01629.1)
MBO: Mb1784c(plcD)
MBB: BCG_1794c(plcD)
MBT: JTY_1769(plcD)
MUL: MUL_2799(plcB)
MAB: MAB_0555
MMI: MMAR_1485(plcB_2) MMAR_3566(plcB) MMAR_3656(plcB_5)
MMAR_3657(plcB_4) MMAR_3823(plcB_1) MMAR_4722(plcB_6)
RHA: RHA1_ro02476
RER: RER_56920(plc)
ROP: ROP_22030(plc)
SCO: SCO6691(SC4C6.01)
SMA: SAV_1715(plcA)
SGR: SGR_2014 SGR_887
CMI: CMM_0504
CMS: CMS_0264
AAU: AAur_3036
RSA: RSal33209_0619
NCA: Noca_3201
NML: Namu_1749
SEN: SACE_5775(plcN)
CAI: Caci_0180 Caci_0605 Caci_5955 Caci_7366 Caci_7483
AFO: Afer_0521
ABA: Acid345_0731 Acid345_2127 Acid345_3848 Acid345_4181
ACA: ACP_2718 ACP_2725
SUS: Acid_6235 Acid_7328
DFE: Dfer_1225 Dfer_5383
CPI: Cpin_1336
PHE: Phep_0454 Phep_1179 Phep_2380 Phep_2716
MIN: Minf_0115(plcC)
SIS: LS215_1050
SID: M164_0637
SIN: YN1551_2296
MSE: Msed_1010 Msed_1035
 |
|---|
| Structures |
PDB: 1AH7 1CA1 1GYG 1IHJ 1OLP 1P5X 1P6D 1P6E 1QM6 1QMD
2FFZ 2FGN 2HUC 2WXT 2WXU 2WY6 |
|---|
Reference
Authors
Title
Journal
|
1 [PMID:13066482]
DRUZHININA KV, KRITSMAN MG.
[Lecithinase C in animal tissue.]
Biokhimiia. 17 (1952) 77-81. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:807246]
Little C, Otnass AB.
The metal ion dependence of phospholipase C from Bacillus cereus.
Biochim. Biophys. Acta. 391 (1975) 326-33.
Bacillus cereus |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:3086312]
Sheikhnejad RG, Srivastava PN.
Isolation and properties of a phosphatidylcholine-specific
phospholipase C from bull seminal plasma.
J. Biol. Chem. 261 (1986) 7544-9.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:4365891]
Takahashi T, Sugahara T, Ohsaka A.
Purification of Clostridium perfringens phospholipase C
(alpha-toxin) by affinity chromatography on agarose-linked egg-yolk
lipoprotein.
Biochim. Biophys. Acta. 351 (1974) 155-71.
Clostridium perfringens |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.1.4.3
IUBMB Enzyme Nomenclature: 3.1.4.3
ExPASy - ENZYME nomenclature database: 3.1.4.3
BRENDA, the Enzyme Database: 3.1.4.3
CAS: 9001-86-9 |
|---|
