| Entry |
|
|---|
| Name |
alkylglycerophosphoethanolamine phosphodiesterase;
lysophospholipase D |
|---|
| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
 |
|---|
| Sysname |
1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase |
|---|
| Reaction(IUBMB) |
1-alkyl-sn-glycero-3-phosphoethanolamine + H2O = 1-alkyl-sn-glycerol
3-phosphate + ethanolamine [RN:R04362] |
|---|
| Reaction(KEGG) |
R04362;
(other) R07388
 |
|---|
| Substrate |
1-alkyl-sn-glycero-3-phosphoethanolamine [CPD:C04476];
H2O [CPD:C00001] |
|---|
| Product |
1-alkyl-sn-glycerol 3-phosphate [CPD:C03968];
ethanolamine [CPD:C00189] |
|---|
| Comment |
Also acts on acyl and choline analogues. |
|---|
| Pathway |
PATH: ec00565 Ether lipid metabolism |
|---|
| Orthology |
KO: K01122 alkylglycerophosphoethanolamine phosphodiesterase |
|---|
| Genes |
HSA: 5168(ENPP2)
PTR: 464353(ENPP2)
MCC: 705287(ENPP2)
MMU: 18606(Enpp2)
RNO: 84050(Enpp2)
CFA: 482026(ENPP2)
BTA: 532663(ENPP2)
SSC: 100152402
ECB: 100057101
MDO: 100025597
GGA: 420361(ENPP2)
TGU: 100219257
XLA: 380218(enpp2)
XTR: 548690(enpp2)
DRE: 393575(enpp2)
 |
|---|
| Structures |
PDB: 1FJ2 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4855486]
Wykle RL, Schremmer JM.
A lysophospholipase D pathway in the metabolism of ether-linked
lipids in brain microsomes.
J. Biol. Chem. 249 (1974) 1742-6.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.1.4.39
IUBMB Enzyme Nomenclature: 3.1.4.39
ExPASy - ENZYME nomenclature database: 3.1.4.39
BRENDA, the Enzyme Database: 3.1.4.39
CAS: 62213-15-4 |
|---|
