KEGG   ENZYME: 3.1.4.43Help
Entry
EC 3.1.4.43                 Enzyme                                 

Name
glycerophosphoinositol inositolphosphodiesterase;
1,2-cyclic-inositol-phosphate phosphodiesterase;
D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase;
D-inositol 1,2-cyclic phosphate 2-phosphohydrolase;
D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase;
1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase;
inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase
Reaction(IUBMB)
1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = glycerol + 1D-myo-inositol 1-phosphate [RN:R03331]
Reaction(KEGG)
R03331;
(other) R03333
Show
Substrate
1-(sn-glycero-3-phospho)-1D-myo-inositol [CPD:C01225];
H2O [CPD:C00001]
Product
glycerol [CPD:C00116];
1D-myo-inositol 1-phosphate [CPD:C01177]
Comment
This enzyme also hydrolyses Ins(cyclic1,2)P to Ins-1-P
History
EC 3.1.4.43 created 1984, (EC 3.1.4.36 created 1976, incorporated 2002), modified 2002
Orthology
K01124  
glycerophosphoinositol inositolphosphodiesterase
Genes
HSA: 
54857(GDPD2)
PTR: 
465687(GDPD2)
PPS: 
100969535(GDPD2)
GGO: 
101125597(GDPD2)
PON: 
100446576(GDPD2)
NLE: 
100582979(GDPD2)
MCC: 
695687(GDPD2)
MCF: 
102136065(GDPD2)
CJC: 
100412949(GDPD2)
MMU: 
71584(Gdpd2)
RNO: 
302421(Gdpd2)
CGE: 
100771225(Gdpd2)
HGL: 
101706272(Gdpd2)
TUP: 
102484003(GDPD2)
CFA: 
480951(GDPD2)
AML: 
UMR: 
103682623(GDPD2)
FCA: 
101088650(GDPD2)
PTG: 
102967871(GDPD2)
BTA: 
514673(GDPD2)
BOM: 
102272674(GDPD2)
PHD: 
102322450(GDPD2)
CHX: 
102173824(GDPD2)
OAS: 
101101866(GDPD2)
SSC: 
100516309(GDPD2)
CFR: 
102513549(GDPD2)
BACU: 
103013177(GDPD2)
LVE: 
103091359(GDPD2)
ECB: 
100055691(GDPD2)
MYB: 
102238745(GDPD2)
MYD: 
102760571(GDPD2)
PALE: 
102886565(GDPD2)
MDO: 
100014029(GDPD2)
SHR: 
100932224(GDPD2)
GGA: 
422217(GDPD2)
APLA: 
101792816(GDPD2)
TGU: 
100231010(GDPD2)
FAB: 
101814282(GDPD2)
PHI: 
102100679(GDPD2)
FPG: 
101922487(GDPD2)
FCH: 
102051523(GDPD2)
CLV: 
102095560(GDPD2)
ASN: 
102381477(GDPD2)
AMJ: 
102574797(GDPD2)
CMY: 
102941248(GDPD2)
ACS: 
100566715(gdpd2)
PBI: 
103063018(GDPD2)
XTR: 
100038173(gdpd2)
DRE: 
563198(gdpd2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102357097(GDPD2)
 » show all
Taxonomy
Reference
1  [PMID:192216]
  Authors
Dawson RM, Hemington N.
  Title
A phosphodiesterase in rat kidney cortex that hydrolyses glycerylphosphorylinositol.
  Journal
Biochem. J. 162 (1977) 241-5.
Reference
2  [PMID:4342209]
  Authors
Dawson RM, Clarke N.
  Title
D-myoinositol 1:2-cyclic phosphate 2-phosphohydrolase.
  Journal
Biochem. J. 127 (1972) 113-8.
Reference
3  [PMID:4353088]
  Authors
Dawson RM, Clarke NG.
  Title
A comparison of D-inositol 1:2-cyclic phosphate 2-phosphohydrolase with other phosphodiesterases of kidney.
  Journal
Biochem. J. 134 (1973) 59-67.
Reference
4  [PMID:1845995]
  Authors
Ross TS, Majerus PW.
  Title
Inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase. Substrate specificity and regulation of activity by phospholipids, metal ion chelators, and inositol 2-phosphate.
  Journal
J. Biol. Chem. 266 (1991) 851-6.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9076-91-9 72414-13-2

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