KEGG   ENZYME: 3.1.4.45Help
Entry
EC 3.1.4.45                 Enzyme                                 

Name
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase;
alpha-N-acetylglucosaminyl phosphodiesterase;
lysosomal alpha-N-acetylglucosaminidase;
phosphodiester glycosidase;
alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase;
2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase
Reaction(IUBMB)
glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose [RN:R04373]
Reaction(KEGG)
Substrate
glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose [CPD:C04755];
H2O [CPD:C00001]
Product
N-acetyl-D-glucosamine [CPD:C00140];
glycoprotein phospho-D-mannose [CPD:C04010]
Comment
Acts on a variety of compounds in which N-acetyl-D-glucosamine is alpha-linked to a phosphate group, including the biosynthetic intermediates of the high mannose oligosaccharide components of some lysosomal enzymes and the products of EC 2.7.8.17 UDP-N-acetylglucosamine---lysosomal-enzyme N-acetylglucosaminephosphotransferase.
History
EC 3.1.4.45 created 1984
Orthology
K01125  
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Genes
HSA: 
51172(NAGPA)
PTR: 
453894(NAGPA)
PPS: 
100989924(NAGPA)
GGO: 
101130231(NAGPA)
PON: 
100458605(NAGPA)
MCC: 
707352(NAGPA)
MCF: 
102127868(NAGPA)
MMU: 
27426(Nagpa)
RNO: 
360476(Nagpa)
CGE: 
100774024(Nagpa)
HGL: 
101704527(Nagpa)
TUP: 
102497727(NAGPA)
CFA: 
490019(NAGPA)
AML: 
FCA: 
101091582(NAGPA)
BTA: 
515935(NAGPA)
BOM: 
102275466(NAGPA)
PHD: 
102334479(NAGPA)
CHX: 
102169152(NAGPA)
SSC: 
100512596(NAGPA)
CFR: 
102503696(NAGPA)
ECB: 
100069983(NAGPA)
MYB: 
102248654(NAGPA)
MDO: 
100026673(NAGPA)
SHR: 
100916276(NAGPA)
OAA: 
GGA: 
416395(NAGPA)
MGP: 
TGU: 
100217812(NAGPA)
FAB: 
101813573(NAGPA)
PHI: 
102111151(NAGPA)
APLA: 
101800969(NAGPA)
FPG: 
101919735(NAGPA)
FCH: 
102052824(NAGPA)
CLV: 
102097700(NAGPA)
ASN: 
102386970(NAGPA)
PSS: 
102457278(NAGPA)
ACS: 
XTR: 
100380073(nagpa)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
SPU: 
NVE: 
HMG: 
TAD: 
AQU: 
MBR: 
 » show all
Taxonomy
Reference
1
  Authors
Van den Tweel, W.J.J., Smits, J.P., Ogg, R.L.H.P. and de Bont, J.A.M.
  Title
The involvement of an enantioselective transaminase in the metabolism of D-3- and D-4-hydroxyphenylglycine in Pseudomonas putida.
  Journal
Appl. Microbiol. Biotechnol. 29 (1988) 224-230.
Reference
2  [PMID:4399430]
  Authors
van der Drift C, van Helvoort PE, Vogels GD.
  Title
S-ureidoglycolate dehydrogenase: purification and properties.
  Journal
Arch. Biochem. Biophys. 145 (1971) 465-9.
Reference
3  [PMID:237557]
  Authors
Van der Drift L, Vogels GD, Van der Drift C.
  Title
Allantoin racemase: a new enzyme from Pseudomonas species.
  Journal
Biochim. Biophys. Acta. 391 (1975) 240-8.
Reference
4  [PMID:6263889]
  Authors
Waheed A, Hasilik A, von Figura K.
  Title
Processing of the phosphorylated recognition marker in lysosomal enzymes. Characterization and partial purification of a microsomal alpha-N-acetylglucosaminyl phosphodiesterase.
  Journal
J. Biol. Chem. 256 (1981) 5717-21.
  Organism
Homo sapiens [GN:hsa], Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
75788-84-0

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