KEGG   ENZYME: 3.1.6.1Help
Entry
EC 3.1.6.1                  Enzyme                                 
Name arylsulfatase;
sulfatase;
nitrocatechol sulfatase;
phenolsulfatase;
phenylsulfatase;
p-nitrophenyl sulfatase;
arylsulfohydrolase;
4-methylumbelliferyl sulfatase;
estrogen sulfatase;
arylsulfatase C;
arylsulfatase B;
arylsulfatase A
Class Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
BRITE hierarchy
Sysname aryl-sulfate sulfohydrolase
Reaction(IUBMB) a phenol sulfate + H2O = a phenol + sulfate [RN:R01243]
Reaction(KEGG) R01243 > R03980;
(other) R04856 R06280(G)
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Substrate phenol sulfate [CPD:C02180];
H2O [CPD:C00001]
Product phenol [CPD:C00146];
sulfate [CPD:C00059]
Comment A group of enzymes with rather similar specificities.
Pathway PATH: ec00140  Steroid hormone biosynthesis
PATH: ec00600  Sphingolipid metabolism
Orthology KO: K01130  arylsulfatase
Genes KLA: KLLA0F03146g
DHA: DEHA0F17710g
YLI: YALI0D26488g
SPO: SPBPB10D8.02c
MGR: MGG_10308
ANI: AN6847.2
AFM: AFUA_5G12940 AFUA_8G02520
AOR: AO090120000416
ANG: An01g06640 An08g08530
CNE: CNC06820
UMA: UM05068.1
ECO: b3801(aslA)
ECJ: JW3773(aslA)
ECD: ECDH10B_3991(aslA)
EBW: BWG_3480(aslA)
ECE: Z5314(aslA)
ECS: ECs4731
ECF: ECH74115_5237(aslA)
ETW: ECSP_4852(aslA)
ECC: c4719(aslA)
ECI: UTI89_C4359(aslA)
ECP: ECP_3993
ECV: APECO1_2677(aslA)
ECM: EcSMS35_4166(aslA)
ECT: ECIAI39_2989(aslA)
ECZ: ECS88_4222(aslA)
EUM: ECUMN_4324(aslA)
ELF: LF82_0162(aslA)
EBL: B21_03625(aslA)
EBD: ECBD_4241
EBR: ECB_03676(aslA)
SPQ: SPAB_03892
SEI: SPC_3189
SEC: SC3062(ars)
SEH: SeHA_C3364
SEE: SNSL254_A3371
SEW: SeSA_A3297
SED: SeD_A3466
SEG: SG3016
SET: SEN2965
SES: SARI_04509
STM: STM3122
SDY: SDY_3945(aslA)
KPN: KPN_00527
KPU: KP1_1453
VVU: VV2_0149 VV2_0151
VVY: VVA0659 VVA0661
VPA: VPA0600 VPA0680 VPA0683
VFI: VF_1427(aslA) VF_1428 VF_1430 VF_A0899 VF_A0992(ydeN)
PAE: PA0183(atsA)
PAU: PA14_02310(atsA)
PAP: PSPA7_2624 PSPA7_3903
PPU: PP_3352
PPF: Pput_2406
PFL: PFL_0205 PFL_2842
PFO: Pfl01_0208
PFS: PFLU0198(atsA)
ACI: ACIAD1598(atsA)
ACB: A1S_0977
ABM: ABSDF2424(atsA)
ABY: ABAYE2815(atsA)
ABN: AB57_1056
ABB: ABBFA_002632
SSE: Ssed_3990
SHE: Shewmr4_2074 Shewmr4_3391
SHM: Shewmr7_0562 Shewmr7_1901
SWP: swp_2417
CPS: CPS_0660 CPS_0841(atsA) CPS_2983 CPS_2984 CPS_2985 CPS_3032
PAT: Patl_0383 Patl_0870
FTU: FTT_0783(ars)
FTF: FTF0783(ars)
REU: Reut_A2893 Reut_B4569
REH: H16_A1602 H16_B0315 H16_B0483
RME: Rmet_5416 Rmet_5423
CTI: RALTA_B0519
BUR: Bcep18194_B2584
BCH: Bcen2424_3543
BCM: Bcenmc03_3976
BAM: Bamb_5276
BMJ: BMULJ_03386(aslA)
BXE: Bxe_A2132
BPE: BP1635
BPA: BPP2750
BBR: BB2736
MPT: Mpe_A2680
MMS: mma_2424(aslA2)
APP: CAP2UW1_0197 CAP2UW1_1266 CAP2UW1_1308
SUN: SUN_1413 SUN_2381
MXA: MXAN_6507
SCL: sce7731(atsA)
MLO: mll5471
PLA: Plav_2014
SME: SM_b20915(aslA1) SMa0943
RLE: RL1149 RL1237 RL1238 RL1911 RL1918 RL2264 RL2267
BJA: bll5074(arsA)
BBT: BBta_0599 BBta_3535
RPD: RPD_1640
MEX: Mext_0526
SIL: SPO3286(atsA)
RDE: RD1_0531 RD1_3744
DSH: Dshi_0936 Dshi_3111(aslA)
HNE: HNE_2211
NAR: Saro_0534
SAL: Sala_0299
SWI: Swit_2516 Swit_3043
MTU: Rv0663(atsD) Rv0711(atsA) Rv3299c(atsB)
MTC: MT0692 MT0738(atsA) MT3398
MRA: MRA_0673(atsD) MRA_0719(atsA) MRA_3340(atsB)
MBO: Mb0682(atsD) Mb0731(atsAa) Mb0732(atsAb) Mb3327c(atsB)
MBB: BCG_0712(atsD) BCG_0761(atsA) BCG_3328c(atsB) BCG_3364c(atsB_2)
MBT: JTY_0682(atsD)
MPA: MAP4171(atsA)
MAV: MAV_2989 MAV_4461
MSM: MSMEG_1451
MUL: MUL_0227(aslA) MUL_0454(atsD) MUL_2658(atsB)
MVA: Mvan_1317 Mvan_4467
MGI: Mflv_5039 Mflv_5494
MAB: MAB_4307
MMC: Mmcs_1023 Mmcs_3964 Mmcs_4113
MKM: Mkms_1040 Mkms_4038 Mkms_4188
MJL: Mjls_1052 Mjls_3978 Mjls_4344
CGL: NCgl2422(cgl2508)
CEF: CE1568
RHA: RHA1_ro02004 RHA1_ro03308 RHA1_ro04570 RHA1_ro05958
ROP: ROP_42010
SEN: SACE_3101(atsD)
STP: Strop_2930
SUS: Acid_1528 Acid_5306
BTH: BT_3093
BFR: BF0017
BFS: BF0016
FJO: Fjoh_3142 Fjoh_3143 Fjoh_3283 Fjoh_4652
AMU: Amuc_0565
RBA: RB11116(aslA) RB1477(atsA) RB1610(aslA) RB1736 RB2367
     RB3876(arsA) RB3877(aslA) RB607 RB684 RB686 RB7772(atsA)
     RB9498(arsA) RB9530(aslA)
CYT: cce_1253 cce_3848 cce_3858 cce_3870
CYC: PCC7424_1202
NPU: Npun_F2392
AVA: Ava_0111
PMT: PMT1515
PMF: P9303_04271
MAC: MA2648(atsA)
MBA: Mbar_A3081
MMA: MM_1892
HWA: HQ2428A(aslA) HQ2690A(aslA) HQ3203A(aslA) HQ3464A(aslA)
     HQ3540A(aslA) HQ3543A
NPH: NP0946A
RCI: RCIX63(atsA)
Taxonomy
Structures PDB: 1HDH  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:13363831]
DODGSON KS, SPENCER B, WILLIAMS K.
Studies on sulphatases.  13.  The hydrolysis of substituted phenyl
sulphates by the arylsulphatase of Alcaligenes metalcaligenes.
Biochem. J. 64 (1956) 216-21.
Alcaligenes metacaligenes
Reference
  Authors
  Title
  Journal
 2  [PMID:13744184]
ROY AB.
The synthesis and hydrolysis of sulfate esters.
Adv. Enzymol. Relat. Subj. Biochem. 22 (1960) 205-35.
Reference
  Authors
  Title
  Journal
  Organism
 3  [PMID:13772]
Roy AB.
Sulphatases, lysosomes and disease.
Aust. J. Exp. Biol. Med. Sci. 54 (1976) 111-35.
Homo sapiens [GN:hsa], Bos taurus [GN:bta], Sus scofa [GN:ssc]
Reference
  Authors
  Title

  Journal
  Organism
 4  [PMID:13843260]
WEBB EC, MORROW PF.
The activation of an arysulphatase from ox liver by chloride and
other anions.
Biochem. J. 73 (1959) 7-15.
Bos taurus [GN:bta]
Other DBs ExplorEnz - The Enzyme Database: 3.1.6.1
IUBMB Enzyme Nomenclature: 3.1.6.1
ExPASy - ENZYME nomenclature database: 3.1.6.1
BRENDA, the Enzyme Database: 3.1.6.1
CAS: 9016-17-5
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