KEGG   ENZYME: 3.1.6.13Help
Entry
EC 3.1.6.13                 Enzyme                                 

Name
iduronate-2-sulfatase;
chondroitinsulfatase;
idurono-2-sulfatase;
iduronide-2-sulfate sulfatase;
L-iduronosulfatase;
L-idurono sulfate sulfatase;
iduronate sulfatase;
sulfo-L-iduronate sulfatase;
L-iduronate 2-sulfate sulfatase;
sulfoiduronate sulfohydrolase;
2-sulfo-L-iduronate 2-sulfatase;
iduronate-2-sulfate sulfatase;
iduronate sulfate sulfatase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
BRITE hierarchy
Sysname
L-iduronate-2-sulfate 2-sulfohydrolase
Reaction(IUBMB)
Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin [RN:R07812 R07821]
Reaction(KEGG)
R07812(G) R07821(G)
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History
EC 3.1.6.13 created 1984
Pathway
Glycosaminoglycan degradation
Metabolic pathways
Orthology
K01136  
iduronate 2-sulfatase
Genes
HSA: 
3423(IDS)
PTR: 
465896(IDS)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
700892(IDS)
MCF: 
CJC: 
MMU: 
15931(Ids)
RNO: 
363513(Ids)
CGE: 
HGL: 
TUP: 
CFA: 
492194(IDS)
AML: 
FCA: 
PTG: 
BTA: 
541272(IDS)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
BACU: 
LVE: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
422392(IDS)
MGP: 
APLA: 
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XTR: 
DRE: 
559959(ids)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
724550(GB18855)
NVI: 
TCA: 
BMOR: 
PHU: 
NVE: 
AQU: 
MBR: 
EHX: 
RBA: 
 » show all
Taxonomy
Reference
1  [PMID:6816283]
  Authors
Archer IM, Harper PS, Wusteman FS.
  Title
Multiple forms of iduronate 2-sulphate sulphatase in human tissues and body fluids.
  Journal
Biochim. Biophys. Acta. 708 (1982) 134-40.
Reference
2  [PMID:4269173]
  Authors
Bach G, Eisenberg F Jr, Cantz M, Neufeld EF.
  Title
The defect in the Hunter syndrome: deficiency of sulfoiduronate sulfatase.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 70 (1973) 2134-8.
Reference
3  [PMID:6945876]
  Authors
Di Natale P, Ronsisvalle L.
  Title
Identification and partial characterization of two enzyme forms of iduronate sulfatase from human placenta.
  Journal
Biochim. Biophys. Acta. 661 (1981) 106-11.
Reference
4  [PMID:6950934]
  Authors
Yutaka T, Fluharty AL, Stevens RL, Kihara H.
  Title
Purification and some properties of human liver iduronate sulfatase.
  Journal
J. Biochem. (Tokyo). 91 (1982) 433-41.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
50936-59-9

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