| Entry |
|
|---|
| Name |
N-acetylglucosamine-6-sulfatase;
chondroitinsulfatase;
O,N-disulfate O-sulfohydrolase;
acetylglucosamine 6-sulfatase;
N-acetylglucosamine 6-sulfate sulfatase;
acetylglucosamine 6-sulfatase;
2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase |
|---|
| Class |
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
 |
|---|
| Sysname |
N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase |
|---|
| Reaction(IUBMB) |
Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine
6-sulfate units of heparan sulfate and keratan sulfate [RN:R07808
R07819] |
|---|
| Reaction(KEGG) |
R07808(G) R07819(G)
 |
|---|
| Comment |
May be identical with EC 3.1.6.11 disulfoglucosamine-6-sulfatase. |
|---|
| Pathway |
PATH: ec00531 Glycosaminoglycan degradation
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01137 N-acetylglucosamine-6-sulfatase |
|---|
| Genes |
HSA: 2799(GNS)
PTR: 467054(GNS)
MCC: 717500(GNS)
MMU: 75612(Gns)
RNO: 299825(Gns)
CFA: 474429(GNS)
BTA: 512444(GNS)
ECB: 100034131(G6S)
OAA: 100076329
GGA: 417829(GNS)
XLA: 379953(gns)
XTR: 100135105
DRE: 327635(gnsb) 566506
BFO: BRAFLDRAFT_219258
CIN: 100187080
SPU: 588183
DME: Dmel_CG18278 Dmel_CG30059
DPO: Dpse_GA24970
DAN: Dana_GF11188
AGA: AgaP_AGAP004721
AAG: AaeL_AAEL004460
AME: 550869
TCA: 662227
NVE: NEMVE_v1g80221
MBR: MONBRDRAFT_29207 MONBRDRAFT_849
VFI: VF_A1007(yidJ)
FRA: Francci3_2189
RBA: RB200 RB4880 RB973
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:762121]
Basner R, Kresse H, von Figura K.
N-Acetylglucosamine-6-sulfate sulfatase from human urine.
J. Biol. Chem. 254 (1979) 1151-8.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:6458607]
Kresse H, Fuchs W, Glossl J, Holtfrerich D, Gilberg W.
Liberation of N-acetylglucosamine-6-sulfate by human
beta-N-acetylhexosaminidase A.
J. Biol. Chem. 256 (1981) 12926-32.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:6451222]
Weissmann B, Chao H, Chow P.
A glucosamine O,N-disulfate O-sulfohydrolase with a probable role in
mammalian catabolism of heparan sulfate.
Biochem. Biophys. Res. Commun. 97 (1980) 827-33.
Rattus norvegicus [GN:rno], Bos taurus [GN:bta] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.1.6.14
IUBMB Enzyme Nomenclature: 3.1.6.14
ExPASy - ENZYME nomenclature database: 3.1.6.14
BRENDA, the Enzyme Database: 3.1.6.14
CAS: 65666-34-4 |
|---|
