KEGG   ENZYME: 3.1.6.14Help
Entry
EC 3.1.6.14                 Enzyme                                 

Name
N-acetylglucosamine-6-sulfatase;
chondroitinsulfatase;
O,N-disulfate O-sulfohydrolase;
acetylglucosamine 6-sulfatase;
N-acetylglucosamine 6-sulfate sulfatase;
acetylglucosamine 6-sulfatase;
2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
BRITE hierarchy
Sysname
N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase
Reaction(IUBMB)
Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate [RN:R07808 R07819]
Reaction(KEGG)
R07808(G) R07819(G)
Show
Comment
May be identical with EC 3.1.6.11 disulfoglucosamine-6-sulfatase.
History
EC 3.1.6.14 created 1984
Pathway
Glycosaminoglycan degradation
Metabolic pathways
Orthology
K01137  
N-acetylglucosamine-6-sulfatase
Genes
HSA: 
2799(GNS)
PTR: 
467054(GNS)
PPS: 
GGO: 
PON: 
MCC: 
717500(GNS)
MCF: 
MMU: 
75612(Gns)
RNO: 
CGE: 
HGL: 
TUP: 
CFA: 
474429(GNS)
AML: 
FCA: 
PTG: 
BTA: 
512444(GNS)
BOM: 
PHD: 
CHX: 
SSC: 
CFR: 
ECB: 
MYB: 
MYD: 
PALE: 
SHR: 
OAA: 
GGA: 
417829(GNS)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
PSS: 
ACS: 
XLA: 
379953(gns)
XTR: 
DRE: 
327635(gnsb) 566506(gnsa)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
550869(GB13647)
NVI: 
TCA: 
BMOR: 
PHU: 
NVE: 
MBR: 
EHX: 
VFI: 
VF_A1007(yidJ)
FRA: 
RBA: 
 » show all
Taxonomy
Reference
1  [PMID:762121]
  Authors
Basner R, Kresse H, von Figura K.
  Title
N-Acetylglucosamine-6-sulfate sulfatase from human urine.
  Journal
J. Biol. Chem. 254 (1979) 1151-8.
  Organism
Homo sapiens
Reference
2  [PMID:6458607]
  Authors
Kresse H, Fuchs W, Glossl J, Holtfrerich D, Gilberg W.
  Title
Liberation of N-acetylglucosamine-6-sulfate by human beta-N-acetylhexosaminidase A.
  Journal
J. Biol. Chem. 256 (1981) 12926-32.
  Organism
Homo sapiens
Reference
3  [PMID:6451222]
  Authors
Weissmann B, Chao H, Chow P.
  Title
A glucosamine O,N-disulfate O-sulfohydrolase with a probable role in mammalian catabolism of heparan sulfate.
  Journal
Biochem. Biophys. Res. Commun. 97 (1980) 827-33.
  Organism
Rattus norvegicus, Bos taurus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
65666-34-4

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