KEGG   ENZYME: 3.1.6.2Help
Entry
EC 3.1.6.2                  Enzyme                                 
Name
steryl-sulfatase;
arylsulfatase;
steroid sulfatase;
sterol sulfatase;
dehydroepiandrosterone sulfate sulfatase;
arylsulfatase C;
steroid 3-sulfatase;
steroid sulfate sulfohydrolase;
dehydroepiandrosterone sulfatase;
pregnenolone sulfatase;
phenolic steroid sulfatase;
3-beta-hydroxysteroid sulfate sulfatase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
BRITE hierarchy
Sysname
steryl-sulfate sulfohydrolase
Reaction(IUBMB)
3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate [RN:R03404]
Reaction(KEGG)
R03404;
(other) R08941 R08942
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Substrate
3beta-hydroxyandrost-5-en-17-one 3-sulfate [CPD:C04555];
H2O [CPD:C00001]
Product
3beta-hydroxyandrost-5-en-17-one [CPD:C01227];
sulfate [CPD:C00059]
Comment
Also acts on some related steryl sulfates.
Pathway
Steroid hormone biosynthesis
Orthology
K01131  
steryl-sulfatase
Genes
HSA: 
412(STS)
PTR: 
465478(STS)
PPS: 
GGO: 
PON: 
MCC: 
707799(STS)
MMU: 
20905(Sts)
RNO: 
24800(Sts)
CFA: 
491727(STS)
AML: 
FCA: 
101082979(STS)
BTA: 
509206(STS)
SSC: 
448816(STS)
ECB: 
100034102(STS)
MDO: 
100032212
SHR: 
100928447(STS)
OAA: 
100084349
GGA: 
418654(STS)
MGP: 
100542513(STS)
TGU: 
100226694(STS)
ACS: 
100558860(sts)
XTR: 
100495327(sts)
TRU: 
101066982
OLA: 
101168602
BFO: 
BRAFLDRAFT_165482
SPU: 
591748
NVE: 
NEMVE_v1g245809
HMG: 
100213116
 » show all
Taxonomy
Reference
1  [PMID:13208702]
  Authors
ROY AB.
  Title
The steroid sulphatase of Patella vulgata.
  Journal
Biochim. Biophys. Acta. 15 (1954) 300-1.
  Organism
Patella vlugata
Reference
2  [PMID:13744184]
  Authors
ROY AB.
  Title
The synthesis and hydrolysis of sulfate esters.
  Journal
Adv. Enzymol. Relat. Subj. Biochem. 22 (1960) 205-35.
Reference
3  [PMID:13355874]
  Authors
HALKERSTON ID, HILLMAN J, STITCH SR.
  Title
The enzymic hydrolysis of steroid conjugates.  I.  Sulphatase and beta-glucuronidase activity of molluscan extracts.
  Journal
Biochem. J. 63 (1956) 705-10.
  Organism
Patella vlugata
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9025-62-1
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