| Entry |
|
|---|
| Name |
steryl-sulfatase;
arylsulfatase;
steroid sulfatase;
sterol sulfatase;
dehydroepiandrosterone sulfate sulfatase;
arylsulfatase C;
steroid 3-sulfatase;
steroid sulfate sulfohydrolase;
dehydroepiandrosterone sulfatase;
pregnenolone sulfatase;
phenolic steroid sulfatase;
3-beta-hydroxysteroid sulfate sulfatase |
|---|
| Class |
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
 |
|---|
| Sysname |
steryl-sulfate sulfohydrolase |
|---|
| Reaction(IUBMB) |
3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O =
3beta-hydroxyandrost-5-en-17-one + sulfate [RN:R03404] |
|---|
| Reaction(KEGG) |
R03404;
(other) R08941 R08942
 |
|---|
| Substrate |
3beta-hydroxyandrost-5-en-17-one 3-sulfate [CPD:C04555];
H2O [CPD:C00001] |
|---|
| Product |
3beta-hydroxyandrost-5-en-17-one [CPD:C01227];
sulfate [CPD:C00059] |
|---|
| Comment |
Also acts on some related steryl sulfates. |
|---|
| Pathway |
PATH: ec00140 Steroid hormone biosynthesis |
|---|
| Orthology |
KO: K01131 steryl-sulfatase |
|---|
| Genes |
HSA: 412(STS)
PTR: 465478(STS)
MCC: 707799(STS)
MMU: 20905(Sts)
RNO: 24800(Sts)
CFA: 491727(STS)
BTA: 509206(STS)
ECB: 100034102(STS)
MDO: 100032212
OAA: 100084349
GGA: 418654(STS)
SPU: 591748
NVE: NEMVE_v1g245809
BUR: Bcep18194_B0483
 |
|---|
| Structures |
PDB: 1P49 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13208702]
ROY AB.
The steroid sulphatase of Patella vulgata.
Biochim. Biophys. Acta. 15 (1954) 300-1.
Patella vlugata |
|---|
Reference
Authors
Title
Journal
|
2 [PMID:13744184]
ROY AB.
The synthesis and hydrolysis of sulfate esters.
Adv. Enzymol. Relat. Subj. Biochem. 22 (1960) 205-35. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13355874]
HALKERSTON ID, HILLMAN J, STITCH SR.
The enzymic hydrolysis of steroid conjugates. I. Sulphatase and
beta-glucuronidase activity of molluscan extracts.
Biochem. J. 63 (1956) 705-10.
Patella vlugata |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.1.6.2
IUBMB Enzyme Nomenclature: 3.1.6.2
ExPASy - ENZYME nomenclature database: 3.1.6.2
BRENDA, the Enzyme Database: 3.1.6.2
CAS: 9025-62-1 |
|---|
