KEGG   ENZYME: 3.1.6.4Help
Entry
EC 3.1.6.4                  Enzyme                                 

Name
N-acetylgalactosamine-6-sulfatase;
chondroitin sulfatase;
chondroitinase;
galactose-6-sulfate sulfatase;
acetylgalactosamine 6-sulfatase;
N-acetylgalactosamine-6-sulfate sulfatase;
N-acetylgalactosamine 6-sulfatase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
BRITE hierarchy
Sysname
N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase
Reaction(IUBMB)
Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate [RN:R07806]
Reaction(KEGG)
R07806(G)
Show
History
EC 3.1.6.4 created 1961
Pathway
Glycosaminoglycan degradation
Metabolic pathways
Orthology
K01132  
N-acetylgalactosamine-6-sulfatase
Genes
HSA: 
2588(GALNS)
PTR: 
736362(GALNS)
PPS: 
100990757(GALNS)
GGO: 
101147331(GALNS)
PON: 
100457027(GALNS)
MCC: 
MCF: 
102118579(GALNS)
MMU: 
50917(Galns)
RNO: 
292073(Galns)
CGE: 
100753973(Galns)
HGL: 
101712119(Galns)
TUP: 
102495455(GALNS)
CFA: 
489661(GALNS)
AML: 
FCA: 
101099168(GALNS)
PTG: 
BTA: 
515809(GALNS)
BOM: 
102269249(GALNS)
PHD: 
102318935(GALNS)
CHX: 
102190539(GALNS)
OAS: 
101107214(GALNS)
SSC: 
397000(GALNS)
CFR: 
102509603(GALNS)
BACU: 
103007439(GALNS)
LVE: 
103068680(GALNS)
ECB: 
100051284(GALNS)
MYB: 
102243422(GALNS)
MYD: 
102759580(GALNS)
PALE: 
102887232(GALNS)
MDO: 
100026247(GALNS)
SHR: 
100933785(GALNS)
OAA: 
GGA: 
415848(GALNS)
MGP: 
TGU: 
100222785(GALNS)
FAB: 
101811724(GALNS)
PHI: 
102101123(GALNS)
APLA: 
101792596(GALNS)
FPG: 
101915149(GALNS)
FCH: 
102047887(GALNS)
CLV: 
102096794(GALNS)
ASN: 
102384115(GALNS)
AMJ: 
102560299(GALNS)
PSS: 
102445221(GALNS)
CMY: 
102937794(GALNS)
ACS: 
100556157(galns)
PBI: 
103067280(GALNS)
XLA: 
495239(galns)
XTR: 
100158481(galns) 100485376(galns)
DRE: 
791159(galns)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102351372(GALNS)
CMK: 
103188083(galns)
BFO: 
CIN: 
SPU: 
ISC: 
AQU: 
RBA: 
RB1456 RB7879(GALNS)
 » show all
Taxonomy
Reference
1  [PMID:6939689]
  Authors
Epstein EH Jr, Leventhal ME.
  Title
Steroid sulfatase of human leukocytes and epidermis and the diagnosis of recessive X-linked ichthyosis.
  Journal
J. Clin. Invest. 67 (1981) 1257-62.
Reference
2  [PMID:6213226]
  Authors
Glossl J, Kresse H.
  Title
Impaired degradation of keratan sulphate by Morquio A fibroblasts.
  Journal
Biochem. J. 203 (1982) 335-8.
Reference
3  [PMID:7213753]
  Authors
Lim CT, Horwitz AL.
  Title
Purification and properties of human N-acetylgalactosamine-6-sulfate sulfatase.
  Journal
Biochim. Biophys. Acta. 657 (1981) 344-55.
Reference
4  [PMID:6814909]
  Authors
Sorensen SH, Noren O, Sjostrom H, Danielsen EM.
  Title
Amphiphilic pig intestinal microvillus maltase/glucoamylase. Structure and specificity.
  Journal
Eur. J. Biochem. 126 (1982) 559-68.
Reference
5  [PMID:6809361]
  Authors
Yutaka T, Okada S, Kato T, Inui K, Yabuuhi H.
  Title
Galactose 6-sulfate sulfatase activity in Morquio syndrome.
  Journal
Clin. Chim. Acta. 122 (1982) 169-80.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9025-60-9

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