KEGG   ENZYME: 3.1.6.4Help
Entry
EC 3.1.6.4                  Enzyme                                 
Name
N-acetylgalactosamine-6-sulfatase;
chondroitin sulfatase;
chondroitinase;
galactose-6-sulfate sulfatase;
acetylgalactosamine 6-sulfatase;
N-acetylgalactosamine-6-sulfate sulfatase;
N-acetylgalactosamine 6-sulfatase
Class
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
BRITE hierarchy
Sysname
N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase
Reaction(IUBMB)
Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate [RN:R07806]
Reaction(KEGG)
R07806(G)
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Pathway
Glycosaminoglycan degradation
Metabolic pathways
Orthology
K01132  
N-acetylgalactosamine-6-sulfatase
Genes
HSA: 
2588(GALNS)
PTR: 
736362(GALNS)
PPS: 
100990757(GALNS)
GGO: 
101147331(GALNS)
PON: 
100457027(GALNS)
MCC: 
MMU: 
50917(Galns)
RNO: 
292073(Galns)
CFA: 
489661(GALNS)
AML: 
FCA: 
101099168(GALNS)
BTA: 
515809(GALNS)
SSC: 
397000(GALNS)
ECB: 
100051284
MDO: 
100026247
SHR: 
100933785(GALNS)
OAA: 
100089863
GGA: 
415848(GALNS)
MGP: 
100543323
TGU: 
100222785(GALNS)
ACS: 
100556157
XLA: 
495239(galns)
XTR: 
100158481(galns) 100485376
DRE: 
791159(galns)
TRU: 
101062701
OLA: 
101171730
BFO: 
BRAFLDRAFT_124052 BRAFLDRAFT_99415
CIN: 
100177085
SPU: 
579130 588014
AQU: 
100637906
RBA: 
RB1456 RB7879(GALNS)
 » show all
Taxonomy
Reference
1  [PMID:6939689]
  Authors
Epstein EH Jr, Leventhal ME.
  Title
Steroid sulfatase of human leukocytes and epidermis and the diagnosis of recessive X-linked ichthyosis.
  Journal
J. Clin. Invest. 67 (1981) 1257-62.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:6213226]
  Authors
Glossl J, Kresse H.
  Title
Impaired degradation of keratan sulphate by Morquio A fibroblasts.
  Journal
Biochem. J. 203 (1982) 335-8.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:7213753]
  Authors
Lim CT, Horwitz AL.
  Title
Purification and properties of human N-acetylgalactosamine-6-sulfate sulfatase.
  Journal
Biochim. Biophys. Acta. 657 (1981) 344-55.
  Organism
Homo sapiens [GN:hsa]
Reference
4  [PMID:6814909]
  Authors
Sorensen SH, Noren O, Sjostrom H, Danielsen EM.
  Title
Amphiphilic pig intestinal microvillus maltase/glucoamylase. Structure and specificity.
  Journal
Eur. J. Biochem. 126 (1982) 559-68.
  Organism
Sus scofa [GN:ssc]
Reference
5  [PMID:6809361]
  Authors
Yutaka T, Okada S, Kato T, Inui K, Yabuuhi H.
  Title
Galactose 6-sulfate sulfatase activity in Morquio syndrome.
  Journal
Clin. Chim. Acta. 122 (1982) 169-80.
  Organism
shark
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9025-60-9
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