| Entry |
|
|---|
| Name |
aryldialkylphosphatase;
organophosphate hydrolase;
paraoxonase;
A-esterase;
aryltriphosphatase;
organophosphate esterase;
esterase B1;
esterase E4;
paraoxon esterase;
pirimiphos-methyloxon esterase;
OPA anhydrase;
organophosphorus hydrolase;
phosphotriesterase;
paraoxon hydrolase;
OPH;
organophosphorus acid anhydrase |
|---|
| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-triester hydrolases
 |
|---|
| Sysname |
aryltriphosphate dialkylphosphohydrolase |
|---|
| Reaction(IUBMB) |
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl
alcohol [RN:R03979] |
|---|
| Reaction(KEGG) |
R03979 > R05548;
(other) R05421
 |
|---|
| Substrate |
aryl dialkyl phosphate [CPD:C03254];
H2O [CPD:C00001] |
|---|
| Product |
dialkyl phosphate [CPD:C02534];
aryl alcohol |
|---|
| Cofactor |
Divalent cation [CPD:C00572] |
|---|
| Inhibitor |
Chelating agent [CPD:C00917] |
|---|
| Comment |
Acts on organophosphorus compounds (such as paraoxon) including
esters of phosphonic and phosphinic acids. Inhibited by chelating
agents; requires divalent cations for activity. Previously regarded
as identical with EC 3.1.1.2 arylesterase. |
|---|
| Pathway |
PATH: ec00361 gamma-Hexachlorocyclohexane degradation |
|---|
| Orthology |
KO: K01140 aryldialkylphosphatase |
|---|
| Genes |
HSA: 5444(PON1) 5445(PON2) 5446(PON3)
PTR: 463547(PON1) 463548(PON3) 463549(PON2)
MCC: 699107 699236 699355(PON1)
MMU: 18979(Pon1) 269823(Pon3) 330260(Pon2)
RNO: 296851(Pon2) 84024(Pon1)
CFA: 403855(PON2)
BTA: 281417(PON2) 523798(PON1)
SSC: 100048952(PON1) 100142663(PON2) 733674(PON3)
ECB: 100051896 100062686
MDO: 100017970
GGA: 395830(PON2)
TGU: 100218152
DRE: 554122
SPU: 582780
 |
|---|
| Structures |
PDB: 1EYW 1EZ2 1HZY 1I0B 1I0D 1JGM 1P6B 1P6C 1P9E 1QW7
1V04 2D2G 2D2H 2D2J 2O4M 2O4Q 2OB3 2OQL 2R1K 2R1L
2R1M 2R1N 2R1P 2VC5 2VC7 2ZC1 3A3W 3A3X 3A4J 3C86
3CAK 3CS2 3E3H 3L24 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13032041]
ALDRIDGE WN.
Serum esterases. I. Two types of esterase (A and B) hydrolysing
p-nitrophenyl acetate, propionate and butyrate, and a method for
their determination.
Biochem. J. 53 (1953) 110-7.
Rattus norvegicus [GN:rno], Equus caballus [GN:ecb], Oryctolagus
cuniculus |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:5047702]
Bosmann HB.
Membrane marker enzymes. Characterization of an arylesterase of
guinea pig cerebral cortex utilizing p-nitrophenyl acetate as
substrate.
Biochim. Biophys. Acta. 276 (1972) 180-91.
Cavia porcellus |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:2822017]
Mackness MI, Thompson HM, Hardy AR, Walker CH.
Distinction between 'A'-esterases and arylesterases. Implications
for esterase classification.
Biochem. J. 245 (1987) 293-6.
Homo sapiens [GN:hsa], Mus musculus [GN:mmu], Rattus norvegicus
[GN:rno], Bos taurus [GN:bta], Ovis aries, Capra hircus, Felis
catus, Meles taxus, Oryctolagus cuniculus |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:14420012]
MAIN AR.
The differentiation of the A-type esterases in sheep serum.
Biochem. J. 75 (1960) 188-95.
Ovis aries |
|---|
Reference
Authors
|
5
In: Reiner, E., Aldridge, W.N. and Hoskin, C.G. (Eds.), Enzymes
Hydrolysing Organophosphorus Compounds, Ellis Horwood, Chichester,
UK, 1989. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.1.8.1
IUBMB Enzyme Nomenclature: 3.1.8.1
ExPASy - ENZYME nomenclature database: 3.1.8.1
UM-BBD (Biocatalysis/Biodegradation Database): 3.1.8.1
BRENDA, the Enzyme Database: 3.1.8.1
CAS: 117698-12-1 |
|---|
