| Entry |
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| Name |
diisopropyl-fluorophosphatase;
DFPase;
tabunase;
somanase;
organophosphorus acid anhydrolase;
organophosphate acid anhydrase;
OPA anhydrase;
diisopropylphosphofluoridase;
dialkylfluorophosphatase;
diisopropyl phosphorofluoridate hydrolase;
isopropylphosphorofluoridase;
diisopropylfluorophosphonate dehalogenase
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| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-triester hydrolases
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| Sysname |
diisopropyl-fluorophosphate fluorohydrolase
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| Reaction(IUBMB) |
diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride [RN: R01533]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Acts on phosphorus anhydride bonds (such as phosphorus-halide and phosphorus-cyanide) in organophosphorus compounds (including 'nerve gases'). Inhibited by chelating agents; requires divalent cations. Related to EC 3.1.8.1 aryldialkylphosphatase.
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| Reference |
1 |
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| Authors |
Augustinsson, K.-B. and Heimburger, G. |
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| Title |
Enzymatic hydrolysis of organophosphorus compounds. I. Occurrence of enzymes hydrolysing dimethyl-amido-ethoxy-phosphoryl cyanide (Tabun). |
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| Journal |
Acta Chem. Scand. 8 (1954) 753-761. |
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| Reference |
2 |
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| Authors |
Augustinsson, K.-B. and Heimburger, G. |
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| Title |
Enzymatic hydrolysis of organophosphorus compounds. II. Analysis of reaction products in experiments with Tabun and some properties of blood plasma tabunase. |
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| Journal |
Acta Chem. Scand. 8 (1954) 762-767. |
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| Reference |
3 |
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| Authors |
Augustinsson, K.-B. and Heimburger, G. |
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| Title |
Enzymatic hydrolysis of organophosphorus compounds. IV. Specificity studies. |
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| Journal |
Acta Chem. Scand. 8 (1954) 1533-1541. |
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| Reference |
|
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| Authors |
COHEN JA, WARRINGA MG. |
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| Title |
Purification and properties of dialkylfluorophosphatase. |
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| Journal |
Biochim. Biophys. Acta. 26 (1957) 29-39. |
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| Organism |
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| Reference |
5 |
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| Authors |
Mounter, L.A. |
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| Title |
Enzymic hydrolysis of organophosphorus compounds. |
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| Journal |
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 4, Academic Press, New York, 1960, p. 541-550. |
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| Reference |
6 |
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| Authors |
In: Reiner, E., Aldridge, W.N. and Hoskin, C.G. (Eds.), Enzymes Hydrolysing Organophosphorus Compounds, Ellis Horwood, Chichester, UK, 1989. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9032-18-2 |
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