| Entry |
|
|---|
| Name |
UDP-sulfoquinovose synthase;
sulfite:UDP-glucose sulfotransferase;
UDPsulfoquinovose synthase |
|---|
| Class |
Hydrolases;
Acting on carbon-sulfur bonds;
Acting on carbon-sulfur bonds (only sub-subclass identified to date)
 |
|---|
| Sysname |
UDP-6-sulfo-6-deoxyglucose sulfohydrolase |
|---|
| Reaction(IUBMB) |
UDP-glucose + sulfite = UDP-6-sulfoquinovose + H2O [RN:R05775] |
|---|
| Reaction(KEGG) |
R05775
 |
|---|
| Substrate |
UDP-glucose [CPD:C00029];
sulfite [CPD:C00094] |
|---|
| Product |
UDP-6-sulfoquinovose [CPD:C11521];
H2O [CPD:C00001] |
|---|
| Comment |
Requires NAD+, which appears to oxidize the substrate to
UDP-4-dehydroglucose, which dehydrates to
UDP-4-dehydro-6-deoxygluc-5-enose, to which sulfite can add; the
reaction is completed when the substrate is rehydrogenated at C-4.
The enzyme from Arabidopsis thaliana is specific for UDP-Glc and
sulfite. |
|---|
| Pathway |
PATH: ec00520 Amino sugar and nucleotide sugar metabolism
PATH: ec00561 Glycerolipid metabolism |
|---|
| Orthology |
KO: K06118 UDP-sulfoquinovose synthase |
|---|
| Genes |
ATH: AT4G33030(SQD1)
OSA: 4338660(Os05g0387200)
OLU: OSTLU_46754
CME: CMR012C
NOC: Noc_1509
MES: Meso_2128
RET: RHE_CH03468(sqdB)
RLE: RL3975(sqdB)
RSP: RSP_2569(sqdB)
RSQ: Rsph17025_1954
MMR: Mmar10_2598
MMC: Mmcs_4564
MKM: Mkms_4652
MJL: Mjls_4947
ACE: Acel_0444
SEN: SACE_5690
SYF: Synpcc7942_0578
SYD: Syncc9605_0052
SYR: SynRCC307_0054 SynRCC307_0204
SYX: SynWH7803_0053
CYA: CYA_0577
CYB: CYB_0060
AVA: Ava_0293
PMN: PMN2A_1264
PMB: A9601_18741(sqdB)
PMC: P9515_18551(sqdB)
PMF: P9303_00511(sqdB)
PMG: P9301_18551(sqdB)
PMH: P9215_19381(sqdB)
PME: NATL1_21351(sqdB)
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:9465123]
Essigmann B, Guler S, Narang RA, Linke D, Benning C.
Phosphate availability affects the thylakoid lipid composition and
the expression of SQD1, a gene required for sulfolipid biosynthesis
in Arabidopsis thaliana.
Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 1950-5.
Arabidopsis thaliana [GN:ath] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:10462438]
Essigmann B, Hespenheide BM, Kuhn LA, Benning C.
Prediction of the active-site structure and NAD(+) binding in SQD1,
a protein essential for sulfolipid biosynthesis in Arabidopsis.
Arch. Biochem. Biophys. 369 (1999) 30-41.
Arabidopsis thaliana [GN:ath] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:10557279]
Mulichak AM, Theisen MJ, Essigmann B, Benning C, Garavito RM.
Crystal structure of SQD1, an enzyme involved in the biosynthesis of
the plant sulfolipid headgroup donor UDP-sulfoquinovose.
Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 13097-102.
Arabidopsis thaliana [GN:ath] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:11073956]
Sanda S, Leustek T, Theisen MJ, Garavito RM, Benning C.
Recombinant Arabidopsis SQD1 converts udp-glucose and sulfite to the
sulfolipid head group precursor UDP-sulfoquinovose in vitro.
J. Biol. Chem. 276 (2001) 3941-6.
Arabidopsis thaliana [GN:ath] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.13.1.1
IUBMB Enzyme Nomenclature: 3.13.1.1
ExPASy - ENZYME nomenclature database: 3.13.1.1
BRENDA, the Enzyme Database: 3.13.1.1 |
|---|
