KEGG   ENZYME: 3.2.1.10Help
Entry
EC 3.2.1.10                 Enzyme                                 

Name
oligo-1,6-glucosidase;
limit dextrinase (erroneous);
isomaltase;
sucrase-isomaltase;
exo-oligo-1,6-glucosidase;
dextrin 6alpha-glucanohydrolase;
alpha-limit dextrinase;
dextrin 6-glucanohydrolase;
oligosaccharide alpha-1,6-glucohydrolase;
alpha-methylglucosidase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
oligosaccharide 6-alpha-glucohydrolase
Reaction(IUBMB)
Hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by EC 3.2.1.1 (alpha-amylase), and in isomaltose
Reaction(KEGG)
Comment
This enzyme, like EC 3.2.1.33 (amylo-alpha-1,6-glucosidase), can release an alpha-1->6-linked glucose, whereas the shortest chain that can be released by EC 3.2.1.41 (pullulanase), EC 3.2.1.142 (limit dextrinase), and EC 3.2.1.68 (isoamylase) is maltose. It also hydrolyses isomaltulose (palatinose), isomaltotriose and panose, but has no action on glycogen or phosphorylase limit dextrin. The enzyme from intestinal mucosa is a single polypeptide chain that also catalyses the reaction of EC 3.2.1.48 (sucrose alpha-glucosidase). Differs from EC 3.2.1.33 (amylo-alpha-1,6-glucosidase) in its preference for short-chain substrates and in its not requiring the 6-glucosylated residue to be at a branch point, i.e. linked at both C-1 and C-4.
History
EC 3.2.1.10 created 1961, modified 2000, modified 2013
Pathway
Galactose metabolism
Starch and sucrose metabolism
Metabolic pathways
Orthology
K01182  
oligo-1,6-glucosidase
K01203  
sucrase-isomaltase / oligo-1,6-glucosidase
Genes
HSA: 
6476(SI)
PTR: 
470988(SI)
PPS: 
GGO: 
PON: 
MCC: 
700840(SI)
MCF: 
MMU: 
69983(Sis)
RNO: 
497756(Si)
CGE: 
HGL: 
TUP: 
CFA: 
488141(SI)
AML: 
FCA: 
PTG: 
BTA: 
504366(SI)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
TSP: 
EHI: 
EHI_130690(337.t00007)
EDI: 
ECA: 
ECA1850(palI)
PATR: 
EPY: 
EpC_17230(palI)
EPR: 
EAM: 
EAMY_1858(malL)
EAY: 
EAM_1823(palI)
ERJ: 
ESA: 
CSK: 
CSZ: 
CSI: 
CTU: 
CTU_12510(malL)
KPE: 
KPK_A0108(palI)
SRR: 
SRL: 
SRY: 
SRS: 
SRA: 
PMIB: 
RAH: 
RAA: 
VVU: 
VVY: 
VVM: 
VSP: 
VAN: 
LAG: 
VFM: 
PPR: 
AVL: 
AVD: 
PIN: 
TAU: 
LCH: 
NMU: 
AZA: 
SUR: 
RET: 
REL: 
RLB: 
NGL: 
CAK: 
GOH: 
BSU: 
BSU02840(ycdG) BSU34560(malL)
BSR: 
BSL: 
BSH: 
BSY: 
BSS: 
BST: 
BSO: 
BSN: 
BSQ: 
BSUB: 
BSX: 
C663_0275(ycdG) C663_3342(malL)
BSP: 
BLI: 
BL00491(malL)
BLD: 
BLi00664(malL)
BLH: 
BAO: 
BAMF_0255(ycdG)
BAY: 
BAQ: 
BACAU_0251(malL1)
BYA: 
BAMP: 
BAML: 
BAMA: 
RBAU_0282(ycdG)
BAMN: 
BASU_0267(ycdG)
BAMB: 
BAPNAU_0251(malL1) BAPNAU_3368(malL5)
BAMT: 
BAZ: 
BQL: 
LL3_00266(ycdG)
BXH: 
BQY: 
MUS_0267(ycdG) MUS_3794(malL1)
BAMI: 
BAMC: 
BAMF: 
BAE: 
BHA: 
BAN: 
BA_4231(malL)
BAR: 
GBAA_4231(malL)
BAT: 
BAH: 
BAI: 
BAA_4254(malL)
BAX: 
BANT: 
BANR: 
BANS: 
BAL: 
BCE: 
BCA: 
BCE_4066(malL)
BCZ: 
BCZK3772(malL)
BCR: 
BCB: 
BCU: 
BCG: 
BCQ: 
BCQ_3804(malL)
BCX: 
BCA_4125(malL)
BNC: 
BCF: 
BCER: 
BCY: 
BTK: 
BTL: 
BALH_3635(malL)
BTB: 
BTT: 
BTC: 
BTF: 
BTM: 
BTG: 
BTI: 
BTN: 
BTHT: 
BTHU: 
BWE: 
BTY: 
BPF: 
BMQ: 
BMQ_1439(malL)
BMD: 
BCK: 
BAG: 
BJS: 
BIF: 
OIH: 
GTH: 
GWC: 
GMC: 
AFL: 
Aflv_2271(malL)
HHD: 
HBHAL_2478(malL1) HBHAL_4171(malL2)
TAP: 
SHA: 
SH0072(malL)
LMO: 
LMF: 
LMH: 
LMC: 
LMN: 
LMY: 
LMT: 
LMG: 
LMS: 
LMJ: 
LMQ: 
LML: 
lmo4a_0200(malL-1) lmo4a_0280(malL-2)
LMP: 
LMW: 
LMX: 
LMZ: 
LMON: 
LMOC: 
LMOS: 
LMOO: 
LMOY: 
LMOT: 
LMOA: 
LMOL: 
LMOL312_0182(malL-1) LMOL312_0255(malL-2)
LMOG: 
BN389_01970(malL) BN389_02730(malL_2)
LMOE: 
LMOB: 
LMOJ: 
LMOZ: 
LMOD: 
LMOW: 
LMOX: 
LMOQ: 
LMR: 
LIN: 
LWE: 
lwe0225(malL)
LSG: 
lse_0161(malL)
LIV: 
LIW: 
ESI: 
EAT: 
EAN: 
EXM: 
PPY: 
PPM: 
PPO: 
PPM_0433(malL)
PPOL: 
PPQ: 
PMS: 
PMQ: 
PMW: 
PTA: 
PSAB: 
STB: 
SGPB_0717(malL)
SCP: 
SCF: 
SIG: 
SIP: 
LPL: 
LPJ: 
JDM1_0178(agl2) JDM1_0181(agl3) JDM1_2897(agl6)
LPT: 
LPS: 
LPST_C0155(agl2) LPST_C0157(agl3) LPST_C1936(treC)
LPR: 
LBP_cg0160(agl2) LBP_cg0163(agl3) LBP_p3g004(agl3)
LPZ: 
LJO: 
LJF: 
LSL: 
LSI: 
LBK: 
LCA: 
LCB: 
LCZ: 
LCS: 
LCE: 
LCW: 
LCL: 
LGA: 
LRE: 
LRU: 
LRT: 
LRR: 
LFE: 
LFR: 
LFF: 
LRH: 
LGG_02696(treC)
LRG: 
LRL: 
LRA: 
LRHK_2786(malL) LRHK_436(malL) LRHK_504(malL)
LRO: 
LRC: 
LBH: 
LBN: 
LSN: 
LSA_01770(malL)
LPI: 
LPQ: 
PPE: 
PCE: 
PECL_405(malL)
OOE: 
LME: 
LMM: 
LMK: 
LCI: 
LKI: 
LGS: 
LEGAS_1054(alg2) LEGAS_1146(alg4) LEGAS_1148(agl1) LEGAS_1806(alg3)
LEC: 
LCN: 
LGE: 
CAW: 
CBK: 
CBT: 
CBE: 
CSR: 
Cspa_c17490(malL1) Cspa_c49840(malL2)
CPAS: 
CLT: 
EHA: 
RUM: 
FPR: 
BFI: 
RHO: 
RIX: 
RIM: 
CCT: 
ROB: 
RTO: 
CPY: 
CSH: 
ERE: 
ERT: 
ERA: 
BPRL: 
TIT: 
TMT: 
CSC: 
ATE: 
COB: 
CHD: 
COW: 
CKI: 
CKN: 
CLC: 
TOC: 
TTM: 
TTO: 
HOR: 
HAS: 
HPK: 
HHL: 
MPU: 
MGF: 
MSY: 
MLC: 
ABRA: 
SSX: 
SFI: 
ART: 
RMU: 
RDN: 
SKE: 
CFL: 
CFI: 
CGA: 
PPC: 
PBO: 
MPH: 
MLP_19390(malL) MLP_49990(malL)
NDA: 
NAL: 
B005_5471(malL)
NML: 
GOB: 
BSD: 
MMAR: 
AMI: 
SESP: 
BN6_23950(malL3)
AMS: 
ASE: 
ACPL_6822(malL)
ACTN: 
L083_6403(treS)
AFS: 
TPY: 
BLO: 
BL1526(agl)
BLJ: 
BLN: 
BLON: 
BLF: 
BLL: 
BLB: 
BLM: 
BLK: 
BLG: 
BAD: 
BLA: 
BLC: 
BLT: 
BBB: 
BBC: 
BNM: 
BLV: 
BLW: 
BLS: 
BANI: 
BANL: 
BNI: 
BDE: 
BBV: 
BBRU: 
Bbr_0559(agl2) Bbr_1855(agl1)
BBRE: 
BBRV: 
BBRJ: 
BBRC: 
BBRN: 
BBRS: 
BS27_0548(agl2) BS27_1848(agl1)
BAST: 
BTP: 
GVA: 
GVG: 
GVH: 
TDE: 
TBE: 
SSM: 
STA: 
STQ: 
SFC: 
SLR: 
SCC: 
LIL: 
LA_1466(amyA)
ACM: 
TRS: 
RBA: 
PDI: 
OSP: 
CPI: 
NKO: 
SLI: 
HSW: 
MTT: 
FBR: 
KDI: 
ZGA: 
PTQ: 
POM: 
DDR: 
DGO: 
DPD: 
HHI: 
HAH_0971(aglA1)
HHN: 
HTI: 
HME: 
HFX_1044(amy3)
 » show all
Taxonomy
Reference
1  [PMID:291933]
  Authors
Hauri HP, Quaroni A, Isselbacher KJ.
  Title
Biogenesis of intestinal plasma membrane: posttranslational route and cleavage of sucrase-isomaltase.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 76 (1979) 5183-6.
Reference
2  [PMID:7002920]
  Authors
Sjostrom H, Noren O, Christiansen L, Wacker H, Semenza G.
  Title
A fully active, two-active-site, single-chain sucrase.isomaltase from pig small intestine. Implications for the biosynthesis of a mammalian integral stalked membrane protein.
  Journal
J. Biol. Chem. 255 (1980) 11332-8.
Reference
3  [PMID:6479163]
  Authors
Rodriguez IR, Taravel FR, Whelan WJ.
  Title
Characterization and function of pig intestinal sucrase-isomaltase and its separate subunits.
  Journal
Eur. J. Biochem. 143 (1984) 575-82.
Reference
4  [PMID:6060462]
  Authors
Khan NA, Eaton NR
  Title
Purification and characterization of maltase and alpha-methyl glucosidase from yeast.
  Journal
Biochim. Biophys. Acta. 146 (1967) 173-80.
Reference
5  [PMID:15291818]
  Authors
Yamamoto K, Nakayama A, Yamamoto Y, Tabata S
  Title
Val216 decides the substrate specificity of alpha-glucosidase in Saccharomyces cerevisiae.
  Journal
Eur. J. Biochem. 271 (2004) 3414-20.
  Sequence
[sce:YGR287C]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9032-15-9

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