| Entry |
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| Name |
keratan-sulfate endo-1,4-beta-galactosidase;
endo-beta-galactosidase;
keratan sulfate endogalactosidase;
keratanase;
keratan-sulfate 1,4-beta-D-galactanohydrolase
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| Class |
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
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| Sysname |
keratan-sulfate 4-beta-D-galactanohydrolase
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| Reaction(IUBMB) |
Endohydrolysis of (1->4)-beta-D-galactosidic linkages in keratan sulfate [RN: R07805]
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| Reaction(KEGG) |
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| Comment |
Hydrolyses the 1,4-beta-D-galactosyl linkages adjacent to 1,3-N-acetyl-alpha-D-glucosaminyl residues. Also acts on some non-sulfated oligosaccharides, but only acts on blood group substances when the 1,2-linked fucosyl residues have been removed (cf. EC 3.2.1.102 blood-group-substance endo-1,4-beta-galactosidase).
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| Pathway |
| Glycosaminoglycan degradation | | Metabolic pathways |
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| Reference |
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| Authors |
Fukuda MN, Matsumura G. |
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| Title |
Endo-beta-galactosidase of Escherichia freundii. Purification and endoglycosidic action on keratan sulfates, oligosaccharides, and blood group active glycoprotein. |
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| Journal |
J. Biol. Chem. 251 (1976) 6218-25. |
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| Organism |
Escherichia freundii |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 55072-01-0 |
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