KEGG   ENZYME: 3.2.1.103Help
Entry
EC 3.2.1.103                Enzyme                                 

Name
keratan-sulfate endo-1,4-beta-galactosidase;
endo-beta-galactosidase;
keratan sulfate endogalactosidase;
keratanase;
keratan-sulfate 1,4-beta-D-galactanohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
keratan-sulfate 4-beta-D-galactanohydrolase
Reaction(IUBMB)
Endohydrolysis of (1->4)-beta-D-galactosidic linkages in keratan sulfate [RN:R07805]
Reaction(KEGG)
R07805(G)
Show
Comment
Hydrolyses the 1,4-beta-D-galactosyl linkages adjacent to 1,3-N-acetyl-alpha-D-glucosaminyl residues. Also acts on some non-sulfated oligosaccharides, but only acts on blood group substances when the 1,2-linked fucosyl residues have been removed (cf. EC 3.2.1.102 blood-group-substance endo-1,4-beta-galactosidase).
History
EC 3.2.1.103 created 1984
Pathway
Glycosaminoglycan degradation
Metabolic pathways
Reference
1  [PMID:135762]
  Authors
Fukuda MN, Matsumura G.
  Title
Endo-beta-galactosidase of Escherichia freundii. Purification and endoglycosidic action on keratan sulfates, oligosaccharides, and blood group active glycoprotein.
  Journal
J. Biol. Chem. 251 (1976) 6218-25.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
55072-01-0

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