| Entry |
|
|---|
| Name |
lactase;
lactase-phlorizin hydrolase |
|---|
| Class |
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl
compounds
 |
|---|
| Sysname |
lactose galactohydrolase |
|---|
| Reaction(IUBMB) |
lactose + H2O = D-galactose + D-glucose [RN:R01100 R06114] |
|---|
| Reaction(KEGG) |
R01100 R06114(G) > R01678 R06098(G)
 |
|---|
| Substrate |
lactose [CPD:C00243];
H2O [CPD:C00001] |
|---|
| Product |
D-galactose [CPD:C00124];
D-glucose [CPD:C00031] |
|---|
| Comment |
The enzyme from intestinal mucosa is isolated as a complex that also
catalyses the reaction of EC 3.2.1.62 glycosylceramidase. cf. EC
3.2.1.33 amylo-alpha-1,6-glucosidase. |
|---|
| Pathway |
PATH: ec00052 Galactose metabolism |
|---|
| Orthology |
KO: K01229 lactase-phlorizin hydrolase |
|---|
| Genes |
HSA: 3938(LCT)
MCC: 707761(LCT)
MMU: 226413(Lct)
RNO: 116569(Lct)
CFA: 483898(LCT)
BTA: 514332(LCT)
ECB: 100055369
OAA: 100084941
GGA: 424294(LCT)
TGU: 100229941
DRE: 796436
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5082068]
Lorenz-Meyer H, Blum AL, Haemmerli HP, Semenza G.
A second enzyme defect in acquired lactase deficiency: lack of
small-intestinal phlorizin-hydrolase.
Eur. J. Clin. Invest. 2 (1972) 326-31.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:810166]
Ramaswamy S, Radhakrishnan AN.
Lactase-phlorizin hydrolase complex from monkey small intestine.
Purification, properties and evidence for two catalytic sites.
Biochim. Biophys. Acta. 403 (1975) 446-55.
monkey |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:5010299]
Schlegel-Haueter S, Hore P, Kerry KR, Semenza G.
The preparation of lactase and glucoamylase of rat small intestine.
Biochim. Biophys. Acta. 258 (1972) 506-19.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:6814489]
Skovbjerg H, Noren O, Sjostrom H, Danielsen EM, Enevoldsen BS.
Further characterization of intestinal lactase/phlorizin hydrolase.
Biochim. Biophys. Acta. 707 (1982) 89-97.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:6786877]
Skovbjerg H, Sjostrom H, Noren O.
Purification and characterisation of amphiphilic lactase/phlorizin
hydrolase from human small intestine.
Eur. J. Biochem. 114 (1981) 653-61.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
|
6 [PMID:5822067]
Asp NG, Dahlqvist A, Koldovsky O.
Human small-intestinal beta-galactosidases. Separation and
characterization of one lactase and one hetero beta-galactosidase.
Biochem. J. 114 (1969) 351-9. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.2.1.108
IUBMB Enzyme Nomenclature: 3.2.1.108
ExPASy - ENZYME nomenclature database: 3.2.1.108
BRENDA, the Enzyme Database: 3.2.1.108
CAS: 9031-11-2 |
|---|
