KEGG   ENZYME: 3.2.1.108Help
Entry
EC 3.2.1.108                Enzyme                                 
Name
lactase;
lactase-phlorizin hydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
lactose galactohydrolase
Reaction(IUBMB)
lactose + H2O = D-galactose + D-glucose [RN:R01100 R06114]
Reaction(KEGG)
Substrate
lactose [CPD:C00243];
H2O [CPD:C00001]
Product
D-galactose [CPD:C00124];
D-glucose [CPD:C00031]
Comment
The enzyme from intestinal mucosa is isolated as a complex that also catalyses the reaction of EC 3.2.1.62 glycosylceramidase. cf. EC 3.2.1.33 amylo-alpha-1,6-glucosidase.
Pathway
Galactose metabolism
Metabolic pathways
Orthology
K01229  
lactase-phlorizin hydrolase
Genes
HSA: 
3938(LCT)
PTR: 
459633(LCT)
PPS: 
GGO: 
PON: 
MCC: 
707761(LCT)
MMU: 
226413(Lct)
RNO: 
116569(Lct)
CFA: 
483898(LCT)
AML: 
FCA: 
101092452(LCT)
BTA: 
514332(LCT)
SSC: 
100625897
ECB: 
100055369
SHR: 
100933904(LCT)
OAA: 
100084941(LCT)
GGA: 
424294(LCT)
TGU: 
100229941(LCT)
XLA: 
100127248(lct.1)
XTR: 
100145766(lct.2)
DRE: 
796436
TRU: 
101066689
OLA: 
101164357 101171223
BFO: 
BRAFLDRAFT_105101(SUFU)
CIN: 
100186561
SPU: 
587972
AAG: 
AaeL_AAEL009246
CQU: 
CpipJ_CPIJ008529
NVE: 
NEMVE_v1g201226
VVI: 
100267558
 » show all
Taxonomy
Reference
1  [PMID:5082068]
  Authors
Lorenz-Meyer H, Blum AL, Haemmerli HP, Semenza G.
  Title
A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase.
  Journal
Eur. J. Clin. Invest. 2 (1972) 326-31.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:810166]
  Authors
Ramaswamy S, Radhakrishnan AN.
  Title
Lactase-phlorizin hydrolase complex from monkey small intestine. Purification, properties and evidence for two catalytic sites.
  Journal
Biochim. Biophys. Acta. 403 (1975) 446-55.
  Organism
monkey
Reference
3  [PMID:5010299]
  Authors
Schlegel-Haueter S, Hore P, Kerry KR, Semenza G.
  Title
The preparation of lactase and glucoamylase of rat small intestine.
  Journal
Biochim. Biophys. Acta. 258 (1972) 506-19.
  Organism
Rattus norvegicus [GN:rno]
Reference
4  [PMID:6814489]
  Authors
Skovbjerg H, Noren O, Sjostrom H, Danielsen EM, Enevoldsen BS.
  Title
Further characterization of intestinal lactase/phlorizin hydrolase.
  Journal
Biochim. Biophys. Acta. 707 (1982) 89-97.
  Organism
Sus scofa [GN:ssc]
Reference
5  [PMID:6786877]
  Authors
Skovbjerg H, Sjostrom H, Noren O.
  Title
Purification and characterisation of amphiphilic lactase/phlorizin hydrolase from human small intestine.
  Journal
Eur. J. Biochem. 114 (1981) 653-61.
  Organism
Homo sapiens [GN:hsa]
Reference
6  [PMID:5822067]
  Authors
Asp NG, Dahlqvist A, Koldovsky O.
  Title
Human small-intestinal beta-galactosidases. Separation and characterization of one lactase and one hetero beta-galactosidase.
  Journal
Biochem. J. 114 (1969) 351-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9031-11-2
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