| Entry |
|
|---|
| Name |
mannosyl-oligosaccharide 1,2-alpha-mannosidase;
mannosidase 1A;
mannosidase 1B;
1,2-alpha-mannosidase;
exo-alpha-1,2-mannanase;
mannose-9 processing alpha-mannosidase;
glycoprotein processing mannosidase I;
mannosidase I;
Man9-mannosidase;
ManI;
1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase |
|---|
| Class |
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl
compounds
 |
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| Sysname |
2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase |
|---|
| Reaction(IUBMB) |
Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in
the oligo-mannose oligosaccharide Man9(GlcNAc)2 |
|---|
| Reaction(KEGG) |
(other) R05982(G) R06722(G)
 |
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| Comment |
Involved in the synthesis of glycoproteins. |
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| Pathway |
PATH: ec00510 N-Glycan biosynthesis
PATH: ec00513 High-mannose type N-glycan biosynthesis
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K01230 mannosyl-oligosaccharide alpha-1,2-mannosidase |
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| Genes |
HSA: 10905(MAN1A2) 11253(MAN1B1) 4121(MAN1A1) 57134(MAN1C1)
PTR: 457159(MAN1A2) 463148(MAN1A1) 473099(MAN1B1)
MCC: 706918(MAN1B1) 711548(MAN1A2)
MMU: 17155(Man1a) 17156(Man1a2) 227619(Man1b1) 230815(Man1c1)
RNO: 294410(Man1a1) 295319(Man1a2) 362625(Man1c1) 499751(Man1b1)
CFA: 476275(MAN1A1) 478178(MAN1C1) 480667(MAN1B1) 483141(MAN1A2)
BTA: 530027(MAN1A1) 615012(MAN1C1)
SSC: 100154147 396919(MAN1A)
ECB: 100057488 100066466 100072869(MAN1A1) 100147680
MDO: 100010854 100022731 100023598
OAA: 100079674 100081124
GGA: 417296(MAN1B1) 418265(MAN1A2) 419588(MAN1C1) 421726(MAN1A1)
TGU: 100223461 100232070
XLA: 446337(man1a2) 447291
XTR: 100145194
DRE: 335538 556237(DKEY-61L1.3) 562592 566078
SPU: 581367 592701
DME: Dmel_CG11874 Dmel_CG31202 Dmel_CG42275(alpha-Man-I)
DPO: Dpse_GA11250 Dpse_GA16089 Dpse_GA17071
AGA: AgaP_AGAP003884
AAG: AaeL_AAEL006074 AaeL_AAEL013678 AaeL_AAEL014721
AME: 413579
TCA: 658773 659709
CEL: ZC410.3(Man(9)-alpha-mannosidase)
NVE: NEMVE_v1g112545 NEMVE_v1g13029
ATH: AT1G30000
OSA: 4336917(Os04g0606400) 4338088(Os05g0209100)
OLU: OSTLU_1811
CME: CMF045C
SCE: YJR131W(MNS1)
AGO: AGOS_AER165W
KLA: KLLA0B04356g
DHA: DEHA0D10153g
PIC: PICST_84949(MNS1)
CGR: CAGL0M00528g
YLI: YALI0D20174g
MGR: MGG_00084 MGG_00667 MGG_11802
ANI: AN0787.2 AN5748.2
AFM: AFUA_1G14560 AFUA_4G10070 AFUA_6G06790 AFUA_6G12360
AFUA_7G02290
AOR: AO090003000057 AO090003000476
ANG: An01g12550 An18g06220
CNE: CNE04550
DDI: DDB_0238229
TVA: TVAG_367080 TVAG_440710
 |
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| Structures |
PDB: 1DL2 1FMI 1G6I 1HCU 1KKT 1KRE 1KRF 1NXC 1X9D 2RI8
2RI9 |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:500665]
Tabas I, Kornfeld S.
Purification and characterization of a rat liver Golgi
alpha-mannosidase capable of processing asparagine-linked
oligosaccharides.
J. Biol. Chem. 254 (1979) 11655-63.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:7061502]
Tulsiani DR, Hubbard SC, Robbins PW, Touster O.
alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is
the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and
mannosidases Ia and IB are the enzymes converting Man9 precursors to
Man5 intermediates.
J. Biol. Chem. 257 (1982) 3660-8.
Rattus norvegicus [GN:rno] |
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| Other DBs |
ExplorEnz - The Enzyme Database: 3.2.1.113
IUBMB Enzyme Nomenclature: 3.2.1.113
ExPASy - ENZYME nomenclature database: 3.2.1.113
BRENDA, the Enzyme Database: 3.2.1.113
CAS: 9068-25-1 |
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