KEGG   ENZYME: 3.2.1.114Help
Entry
EC 3.2.1.114                Enzyme                                 

Name
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase;
mannosidase II;
exo-1,3-1,6-alpha-mannosidase;
alpha-D-mannosidase II;
alpha-mannosidase II;
alpha1-3,6-mannosidase;
GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase;
Golgi alpha-mannosidase II;
ManII;
1,3(1,6)-alpha-D-mannosidase;
1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
(1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase
Reaction(IUBMB)
Hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man5(GlcNAc)3
Reaction(KEGG)
(other) R05984(G)
Show
Comment
Involved in the synthesis of glycoproteins.
History
EC 3.2.1.114 created 1986
Pathway
N-Glycan biosynthesis
Various types of N-glycan biosynthesis
Metabolic pathways
Orthology
K01231  
alpha-mannosidase II
Genes
HSA: 
4122(MAN2A2) 4124(MAN2A1)
PTR: 
461982(MAN2A1) 745986(MAN2A2)
PPS: 
100973826(MAN2A1) 100975142(MAN2A2)
GGO: 
PON: 
100449341(MAN2A2) 100455258(MAN2A1)
NLE: 
100581120(MAN2A1) 100598002(MAN2A2)
MCC: 
705480(MAN2A1)
MCF: 
CJC: 
100394604(MAN2A2) 100415670(MAN2A1)
MMU: 
140481(Man2a2) 17158(Man2a1)
RNO: 
25478(Man2a1) 308757(Man2a2)
CGE: 
100757006(Man2a1) 100764014(Man2a2)
HGL: 
101697315(Man2a1) 101717094(Man2a2)
TUP: 
102469872(MAN2A2) 102485972(MAN2A1)
CFA: 
488745(MAN2A2) 488878(MAN2A1)
AML: 
100474640(MAN2A1) 100475150(MAN2A2)
UMR: 
103660265(MAN2A2) 103675784(MAN2A1)
FCA: 
101086451(MAN2A1) 101101317(MAN2A2)
PTG: 
102953845(MAN2A1) 102959757(MAN2A2) 102964243
BTA: 
521539(MAN2A1) 527449(MAN2A2)
BOM: 
102269911(MAN2A2) 102286530(MAN2A1)
PHD: 
102316836(MAN2A1) 102330792(MAN2A2)
CHX: 
102171012(MAN2A2) 102182591(MAN2A1)
OAS: 
101106798(MAN2A2) 101116572(MAN2A1)
SSC: 
100154397(MAN2A2) 100514631(MAN2A1)
CFR: 
102512093(MAN2A2) 102513706(MAN2A1)
BACU: 
103020657(MAN2A1) 103021128(MAN2A2)
LVE: 
103074675(MAN2A2) 103076739(MAN2A1)
ECB: 
100053432(MAN2A2) 100064575(MAN2A1)
MYB: 
102239755(MAN2A2) 102241544(MAN2A1)
MYD: 
102760778(MAN2A1) 102764752(MAN2A2)
PALE: 
102878318(MAN2A1) 102884371(MAN2A2)
MDO: 
100010442(MAN2A1) 100014504(MAN2A2)
SHR: 
100913308(MAN2A1) 100922248(MAN2A2)
OAA: 
100082559(MAN2A1) 100090754(MAN2A2)
GGA: 
415585(MAN2A2) 415611(MAN2A1)
APLA: 
101790343(MAN2A2) 101792614(MAN2A1)
TGU: 
100226019(MAN2A2) 100227845(MAN2A1)
FAB: 
101806895(MAN2A2) 101819402(MAN2A1)
PHI: 
102101154(MAN2A2) 102113458(MAN2A1)
FPG: 
101913159(MAN2A2) 101915871(MAN2A1)
FCH: 
102048168(MAN2A2) 102050767(MAN2A1)
CLV: 
102090971(MAN2A2) 102097702(MAN2A1)
ASN: 
102369470(MAN2A1) 102383379(MAN2A2)
AMJ: 
102561641(MAN2A1) 102566705(MAN2A2)
PSS: 
102459905(MAN2A1)
CMY: 
102941559(MAN2A2) 102944199(MAN2A1)
ACS: 
100555933(man2a1) 100568077(man2a2)
PBI: 
103053403 103053695(MAN2A1) 103058391(MAN2A2)
XLA: 
443991(man2a2)
XTR: 
100036612(man2a1) 448465(man2a2)
DRE: 
100333987(man2a2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103178412(man2a1) 103188552(man2a2)
BFO: 
CIN: 
SPU: 
DME: 
Dmel_CG18802(alpha-Man-II)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
552382(alpha-Man-II)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_F58H1.1(aman-2)
CBR: 
CBG23330(Cbr-aman-2)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
ATH: 
AT5G14950(GMII)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
101499632(MAN2A2)
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
101208332(MAN2A2)
CMO: 
RCU: 
POP: 
POPTR_0001s34770g POPTR_0008s11620g(POPTRDRAFT_564498) POPTR_0017s11020g(POPTRDRAFT_258765)
VVI: 
100243903(MAN2A2)
SLY: 
SOT: 
OSA: 
DOSA: 
Os06t0245700-00(Os06g0245700)
OBR: 
BDI: 
SBI: 
SORBI_10g008770(SORBIDRAFT_10g008770)
ZMA: 
SITA: 
PDA: 
ATR: 
s00055p00209810(AMTR_s00055p00209810) s00055p00211270(AMTR_s00055p00211270)
SMO: 
PPP: 
DPP: 
DFA: 
ACAN: 
TET: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:6445359]
  Authors
Harpaz N, Schachter H.
  Title
Control of glycoprotein synthesis. Processing of asparagine-linked oligosaccharides by one or more rat liver Golgi alpha-D-mannosidases dependent on the prior action of UDP-N-acetylglucosamine: alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase I.
  Journal
J. Biol. Chem. 255 (1980) 4894-902.
Reference
2  [PMID:7061502]
  Authors
Tulsiani DR, Hubbard SC, Robbins PW, Touster O.
  Title
alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates.
  Journal
J. Biol. Chem. 257 (1982) 3660-8.
Reference
3  [PMID:863880]
  Authors
Tulsiani DR, Opheim DJ, Touster O.
  Title
Purification and characterization of alpha-D-mannosidase from rat liver golgi membranes.
  Journal
J. Biol. Chem. 252 (1977) 3227-33.
Reference
4  [PMID:15721331]
  Authors
Athanasopoulos VI, Niranjan K, Rastall RA.
  Title
The production, purification and characterisation of two novel alpha-D-mannosidases from Aspergillus phoenicis.
  Journal
Carbohydr. Res. 340 (2005) 609-17.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
82047-77-6

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