| Entry |
|
|---|
| Name |
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase;
mannosidase II;
exo-1,3-1,6-alpha-mannosidase;
alpha-D-mannosidase II;
alpha-mannosidase II;
alpha1-3,6-mannosidase;
GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase;
Golgi alpha-mannosidase II;
ManII;
1,3(1,6)-alpha-D-mannosidase;
1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase |
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| Class |
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl
compounds
 |
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| Sysname |
(1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase |
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| Reaction(IUBMB) |
Hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose
residues in the mannosyl-oligosaccharide Man5(GlcNAc)3 |
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| Reaction(KEGG) |
(other) R05984(G)
 |
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| Comment |
Involved in the synthesis of glycoproteins. |
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| Pathway |
PATH: ec00510 N-Glycan biosynthesis
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K01231 alpha-mannosidase II |
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| Genes |
HSA: 4122(MAN2A2) 4124(MAN2A1)
PTR: 461982(MAN2A1) 745986(MAN2A2)
MMU: 140481(Man2a2) 17158(Man2a1)
RNO: 25478(Man2a1) 308757(Man2a2)
CFA: 488745(MAN2A2) 488878(MAN2A1)
BTA: 521539(MAN2A1) 527449(MAN2A2)
SSC: 100154397
ECB: 100064575(MAN2A1)
MDO: 100010442 100014504
OAA: 100082559
GGA: 415585(MAN2A2)
TGU: 100226019 100227845
XLA: 443991
XTR: 448465(man2a2)
DRE: 561043
SPU: 579104
DME: Dmel_CG18802(alpha-Man-II)
DPO: Dpse_GA15085
CEL: F58H1.1(aman-2)
NVE: NEMVE_v1g166900
ATH: AT5G14950(GMII)
OSA: 4340636(Os06g0245700)
TET: TTHERM_00227830 TTHERM_00230960 TTHERM_00629960 TTHERM_00629970
TTHERM_00630020 TTHERM_00630030
 |
|---|
| Structures |
PDB: 1HTY 1HWW 1HXK 1PS3 1QWN 1QWU 1QX1 1R33 1R34 1TQS
1TQT 1TQU 1TQV 1TQW 2ALW 2F18 2F1A 2F1B 2F7O 2F7P
2F7Q 2F7R 2FYV 2OW6 2OW7 3BLB 3BUB 3BUD 3BUI 3BUP
3BUQ 3BVT 3BVU 3BVV 3BVW 3BVX 3CV5 3CZN 3CZS 3D4Y
3D4Z 3D50 3D51 3D52 3DDF 3DDG 3DX0 3DX1 3DX2 3DX3
3DX4 3EJP 3EJQ 3EJR 3EJS 3EJT 3EJU |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:6445359]
Harpaz N, Schachter H.
Control of glycoprotein synthesis. Processing of asparagine-linked
oligosaccharides by one or more rat liver Golgi alpha-D-mannosidases
dependent on the prior action of UDP-N-acetylglucosamine:
alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase I.
J. Biol. Chem. 255 (1980) 4894-902.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:7061502]
Tulsiani DR, Hubbard SC, Robbins PW, Touster O.
alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is
the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and
mannosidases Ia and IB are the enzymes converting Man9 precursors to
Man5 intermediates.
J. Biol. Chem. 257 (1982) 3660-8.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:863880]
Tulsiani DR, Opheim DJ, Touster O.
Purification and characterization of alpha-D-mannosidase from rat
liver golgi membranes.
J. Biol. Chem. 252 (1977) 3227-33.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:15721331]
Athanasopoulos VI, Niranjan K, Rastall RA.
The production, purification and characterisation of two novel
alpha-D-mannosidases from Aspergillus phoenicis.
Carbohydr. Res. 340 (2005) 609-17.
Aspergillus phoenicis |
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| Other DBs |
ExplorEnz - The Enzyme Database: 3.2.1.114
IUBMB Enzyme Nomenclature: 3.2.1.114
ExPASy - ENZYME nomenclature database: 3.2.1.114
BRENDA, the Enzyme Database: 3.2.1.114
CAS: 82047-77-6 |
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