KEGG   ENZYME: 3.2.1.114Help
Entry
EC 3.2.1.114                Enzyme                                 
Name
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase;
mannosidase II;
exo-1,3-1,6-alpha-mannosidase;
alpha-D-mannosidase II;
alpha-mannosidase II;
alpha1-3,6-mannosidase;
GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase;
Golgi alpha-mannosidase II;
ManII;
1,3(1,6)-alpha-D-mannosidase;
1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
(1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase
Reaction(IUBMB)
Hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man5(GlcNAc)3
Reaction(KEGG)
(other) R05984(G)
Show
Comment
Involved in the synthesis of glycoproteins.
Pathway
N-Glycan biosynthesis
Various types of N-glycan biosynthesis
Metabolic pathways
Orthology
K01231  
alpha-mannosidase II
Genes
HSA: 
4122(MAN2A2) 4124(MAN2A1)
PTR: 
461982(MAN2A1) 745986(MAN2A2)
PPS: 
100973826(MAN2A1) 100975142(MAN2A2)
GGO: 
PON: 
100449341(MAN2A2) 100455258(MAN2A1)
MCC: 
705480(MAN2A1)
MMU: 
140481(Man2a2) 17158(Man2a1)
RNO: 
25478(Man2a1) 308757(Man2a2)
CFA: 
488745(MAN2A2) 488878(MAN2A1)
AML: 
100474640(MAN2A1) 100475150(MAN2A2)
FCA: 
101086451(MAN2A1) 101101317(MAN2A2)
BTA: 
521539(MAN2A1) 527449(MAN2A2)
SSC: 
100154397(MAN2A2) 100514631(MAN2A1)
ECB: 
100053432 100064575(MAN2A1)
MDO: 
100010442(MAN2A1) 100014504(MAN2A2)
SHR: 
100913308(MAN2A1) 100922248(MAN2A2)
OAA: 
100082559(MAN2A1) 100090754
GGA: 
415585(MAN2A2) 415611(MAN2A1)
TGU: 
100226019(MAN2A2) 100227845(MAN2A1)
ACS: 
100555933(man2a1) 100568077(man2a2)
XLA: 
443991(man2a2)
XTR: 
100036612(man2a1) 448465(man2a2)
DRE: 
100333987(man2a2)
TRU: 
101061792
OLA: 
101158104
CIN: 
100180083
SPU: 
589339
DME: 
Dmel_CG18802(alpha-Man-II)
DPO: 
Dpse_GA15085
DAN: 
Dana_GF17213
DER: 
Dere_GG16776
DPE: 
Dper_GL13822
DSE: 
Dsec_GM23804
DSI: 
Dsim_GD18615
DWI: 
Dwil_GK10956
DYA: 
Dyak_GE25950
DGR: 
Dgri_GH18434
DMO: 
Dmoj_GI24010
DVI: 
Dvir_GJ23640
AGA: 
AgaP_AGAP004020
AAG: 
AaeL_AAEL011978
CQU: 
CpipJ_CPIJ009720
AME: 
552382(alpha-Man-II)
NVI: 
100116564(NV15211)
TCA: 
660728
API: 
100169064
PHU: 
Phum_PHUM459490
ISC: 
IscW_ISCW018027
CEL: 
CELE_F58H1.1(aman-2)
CBR: 
CBG23330(Cbr-aman-2)
BMY: 
Bm1_29570
TSP: 
Tsp_10745
SMM: 
Smp_143430
NVE: 
NEMVE_v1g166900
HMG: 
100202382
TAD: 
TRIADDRAFT_60265
ATH: 
AT5G14950(GMII)
ALY: 
ARALYDRAFT_488339(ATGMII)
GMX: 
100806647 100811858
MTR: 
MTR_6g008850
CSV: 
101208332(MAN2A2)
RCU: 
RCOM_0852760
POP: 
POPTR_549487
VVI: 
100243903(MAN2A2)
OSA: 
4340636
DOSA: 
Os06t0245700-00(Os06g0245700)
BDI: 
100822520
SBI: 
SORBI_10g008770(SORBIDRAFT_10g008770)
ZMA: 
100502340
SMO: 
SELMODRAFT_116442 SELMODRAFT_154366
PPP: 
PHYPADRAFT_159159
NGR: 
NAEGRDRAFT_57722
TET: 
TTHERM_00227830 TTHERM_00230960 TTHERM_00629960 TTHERM_00629970 TTHERM_00630020 TTHERM_00630030
 » show all
Taxonomy
Reference
1  [PMID:6445359]
  Authors
Harpaz N, Schachter H.
  Title
Control of glycoprotein synthesis. Processing of asparagine-linked oligosaccharides by one or more rat liver Golgi alpha-D-mannosidases dependent on the prior action of UDP-N-acetylglucosamine: alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase I.
  Journal
J. Biol. Chem. 255 (1980) 4894-902.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:7061502]
  Authors
Tulsiani DR, Hubbard SC, Robbins PW, Touster O.
  Title
alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates.
  Journal
J. Biol. Chem. 257 (1982) 3660-8.
  Organism
Rattus norvegicus [GN:rno]
Reference
3  [PMID:863880]
  Authors
Tulsiani DR, Opheim DJ, Touster O.
  Title
Purification and characterization of alpha-D-mannosidase from rat liver golgi membranes.
  Journal
J. Biol. Chem. 252 (1977) 3227-33.
  Organism
Rattus norvegicus [GN:rno]
Reference
4  [PMID:15721331]
  Authors
Athanasopoulos VI, Niranjan K, Rastall RA.
  Title
The production, purification and characterisation of two novel alpha-D-mannosidases from Aspergillus phoenicis.
  Journal
Carbohydr. Res. 340 (2005) 609-17.
  Organism
Aspergillus phoenicis
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
82047-77-6
DBGET integrated database retrieval system