KEGG   ENZYME: 3.2.1.144Help
Entry
EC 3.2.1.144                Enzyme                                 

Name
3-deoxyoctulosonase;
alpha-Kdo-ase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
3-deoxyoctulosonyl-lipopolysaccharide hydrolase
Reaction(IUBMB)
3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide [RN:R06054]
Reaction(KEGG)
Substrate
3-deoxyoctulosonyl-lipopolysaccharide [CPD:C06744];
H2O [CPD:C00001]
Product
3-deoxyoctulosonic acid [CPD:C01187];
lipopolysaccharide [CPD:C00338]
Comment
Releases Kdo (alpha- and beta-linked 3-deoxy-D-manno-octulosonic acid) from different lipopolysaccharides, including Re-LPS from Escherichia coli and Salmonella, Rd-LPS from S. minnesota, and de-O-acyl-re-LPS. 4-Methylumbelliferyl-alpha-Kdo (alpha-Kdo-OMec) is also a substrate.
History
EC 3.2.1.144 created 2000
Reference
1  [PMID:9334217]
  Authors
Li YT, Wang LX, Pavlova NV, Li SC, Lee YC.
  Title
alpha-KDOase activity in oyster and synthesis of alpha- and beta-4-methylumbelliferyl ketosides of 3-deoxy-D-manno-octulosonic acid.
  Journal
J. Biol. Chem. 272 (1997) 26419-24.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
199128-67-1

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