KEGG   ENZYME: 3.2.1.184Help
Entry
EC 3.2.1.184                Enzyme                                 

Name
UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing);
UDP-Bac2Ac4Ac 2-epimerase;
NeuC
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
UDP-N,N'-diacetylbacillosamine hydrolase (2-epimerising)
Reaction(IUBMB)
UDP-N,N'-diacetylbacillosamine + H2O = UDP + 2,4-diacetamido-2,4,6-trideoxy-D-mannopyranose [RN:R10187]
Reaction(KEGG)
Substrate
UDP-N,N'-diacetylbacillosamine [CPD:C20357];
H2O [CPD:C00001]
Product
UDP [CPD:C00015];
2,4-diacetamido-2,4,6-trideoxy-D-mannopyranose [CPD:C20424]
Comment
Requires Mg2+. Involved in biosynthesis of legionaminic acid, a nonulosonate derivative that is incorporated by some bacteria into assorted virulence-associated cell surface glycoconjugates. The initial product formed by the enzyme from Legionella pneumophila, which incorporates legionaminic acid into the O-antigen moiety of its lipopolysaccharide, is 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose, which rapidly mutarotates to a mixture of anomers [1]. The enzyme from Campylobacter jejuni, which incorporates legionaminic acid into flagellin, prefers GDP-N,N'-diacetylbacillosamine [2].
History
EC 3.2.1.184 created 2012
Pathway
Amino sugar and nucleotide sugar metabolism
Orthology
K18429  
GDP/UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing)
Genes
LPN: 
LPH: 
LPV_0879(neuC)
LPO: 
LPO_0834(neuC)
LPU: 
LPM: 
LP6_0733(neuC)
LPF: 
lpl0790(neuC)
LPP: 
lpp0819(neuC)
LPC: 
LPC_2539(neuC)
LPA: 
LPE: 
FPH: 
THI: 
HCP: 
HCB: 
TDN: 
SULR: 
CJE: 
Cj1328(neuC2)
CJB: 
BN148_1328(neuC2)
CJI: 
CJSA_1264(neuC2)
CJS: 
CJS3_1422(neuC)
CJP: 
CJEI: 
N135_01416(neuC_2)
CJER: 
CJR: 
CJE1517(neuC)
CJD: 
CJZ: 
CJX: 
CCO: 
CLA: 
Cla_1234(ptmD)
CCOL: 
CCC: 
CCQ: 
CCF: 
CCY: 
CCOI: 
CAJ: 
ABT: 
ARC: 
PEL: 
GTH: 
PPY: 
PTA: 
PDU: 
EFC: 
EFAU: 
EFU: 
CNO: 
CBL: 
CBB: 
CBN: 
CCB: 
CTH: 
CTX: 
CCL: 
BPB: 
CLE: 
CST: 
DDL: 
TJR: 
DOR: 
AWO: 
TIT: 
TXY: 
TSH: 
HOR: 
HPK: 
SCD: 
LIL: 
LIE: 
LIC: 
SYW: 
SYNW0449(neuC)
PRC: 
SCN: 
PPH: 
PMX: 
MFO: 
MEW: 
 » show all
Taxonomy
Reference
1  [PMID:18275154]
  Authors
Glaze PA, Watson DC, Young NM, Tanner ME
  Title
Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila.
  Journal
Biochemistry. 47 (2008) 3272-82.
  Sequence
[up:Q5ZXH8]
Reference
2  [PMID:19282391]
  Authors
Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM
  Title
The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel  GDP-linked precursors.
  Journal
Glycobiology. 19 (2009) 715-25.
  Sequence
[up:Q0P8T0]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system