| Entry |
|
|---|
| Name |
alpha-glucosidase;
maltase;
glucoinvertase;
glucosidosucrase;
maltase-glucoamylase;
alpha-glucopyranosidase;
glucosidoinvertase;
alpha-D-glucosidase;
alpha-glucoside hydrolase;
alpha-1,4-glucosidase |
|---|
| Class |
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl
compounds
 |
|---|
| Sysname |
alpha-D-glucoside glucohydrolase |
|---|
| Reaction(IUBMB) |
Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose
residues with release of D-glucose |
|---|
| Reaction(KEGG) |
(other) R00028 R00801 R00802 R06084(G) R06087(G) R06088(G)
 |
|---|
| Inhibitor |
Castanospermine [CPD:C02256] |
|---|
| Comment |
This single entry covers a group of enzymes whose specificity is
directed mainly towards the exohydrolysis of (1->4)-alpha-glucosidic
linkages, and that hydrolyse oligosaccharides rapidly, relative to
polysaccharide, which are hydrolysed relatively slowly, or not at
all. The intestinal enzyme also hydrolyses polysaccharides,
catalysing the reactions of EC 3.2.1.3 glucan 1,4-alpha-glucosidase
and, more slowly, hydrolyses (1->6)-alpha-D-glucose links. |
|---|
| Pathway |
PATH: ec00052 Galactose metabolism
PATH: ec00500 Starch and sucrose metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01187 alpha-glucosidase
KO: K12047 maltase-glucoamylase
KO: K12316 lysosomal alpha-glucosidase
KO: K12317 neutral alpha-glucosidase C |
|---|
| Genes |
HSA: 2548(GAA) 2595(GANC) 8972(MGAM)
PTR: 453361(GANC) 454940(GAA) 463790(MGAM)
MCC: 695030(MGAM) 695370(MGAM) 708126(GANC) 712054(GAA)
MMU: 14387(Gaa) 232714(Mgam) 76051(Ganc)
RNO: 24382(Ganc) 312272(Mgam) 367562(Gaa)
CFA: 475523(MGAM) 482756 483352(GAA) 487517(GANC)
BTA: 280798(GAA) 530330(GANC)
ECB: 100056675 100064486 100065270 100070973
MDO: 100009833 100010022 100028995 100030818
GGA: 416462(GAA) 417691 423232(GANC) 425007(SI)
TGU: 100189934(MG) 100222972 100227842
XTR: 100135094
DRE: 100002366(gaa) 100148922 571921
CIN: 100175461 100179130
SPU: 582120 592667
DME: Dmel_CG11669 Dmel_CG11909 Dmel_CG14934 Dmel_CG14935 Dmel_CG7685
Dmel_CG8690 Dmel_CG8693 Dmel_CG8694(LvpD) Dmel_CG8695(LvpL)
Dmel_CG8696(LvpH)
DPO: Dpse_GA13361
AGA: AgaP_AGAP008962
AAG: AaeL_AAEL000642
AME: 409365 411257(Hbg2)
NVI: 100124137
TCA: 658192
API: 100160797
CEL: D2096.3 F52D1.1
BMY: Bm1_40580
NVE: NEMVE_v1g165897
TAD: TRIADDRAFT_26932 TRIADDRAFT_37758
ATH: AT3G45940 AT5G11720 AT5G63840(RSW3)
OSA: 4341824(Os06g0675700) 4341833(Os06g0676700)
PPP: PHYPADRAFT_55427
SCE: YBR299W(MAL32) YGR287C YGR292W(MAL12) YIL172C YJL216C
YJL221C(FSP2) YOL157C
KLA: KLLA0B00242g
DHA: DEHA0A14300g DEHA0B08030g DEHA0D03894g
PIC: PICST_29292(MAL9) PICST_42120(MAL6) PICST_56703(CGA1)
PICST_85073(ROT2)
CAL: CaO19.4899(GCA1)
SPO: SPAPB24D3.10c(agl) SPBC1683.07(mal1)
NCR: NCU02583 NCU06523
PAN: PODANSg09931
MGR: MGG_07547 MGG_10662
ANI: AN2017.2 AN7345.2
AFM: AFUA_1G16250 AFUA_4G10150 AFUA_8G07070
AOR: AO090003001209 AO090005001084 AO090038000471 AO090103000129
ANG: An01g10930 An04g06920(aglU)
NFI: NFIA_105900
SSL: SS1G_01083
BFU: BC1G_12859
CNE: CNF00610 CNH01310 CNN00140
CNB: CNBF4070 CNBL1260
UMA: UM03692.1
DDI: DDB_0237578(gaa)
EHI: EHI_023430 EHI_052770
TET: TTHERM_00013800 TTHERM_00013890 TTHERM_00013900 TTHERM_00181060
TTHERM_00463650
TBR: Tb10.05.0080
LMA: LmjF18.0090
ECO: b0403(malZ)
ECJ: JW0393(malZ)
ECD: ECDH10B_0359(malZ)
EBW: BWG_0285(malZ)
ECE: Z0501(malZ)
ECS: ECs0453
ECF: ECH74115_0480(malZ)
ETW: ECSP_0467(malZ)
ECG: E2348C_0338(malZ)
ECC: c0513(malZ) c4497
ECI: UTI89_C0425(malZ)
ECP: ECP_0462
ECV: APECO1_1607(malZ)
ECW: EcE24377A_0433(malZ)
ECX: EcHS_A0473(malZ)
ECM: EcSMS35_0434(malZ)
ECY: ECSE_0424
ECL: EcolC_3230
ECK: EC55989_0412(malZ)
ECQ: ECED1_0426(malZ)
ECR: ECIAI1_0403(malZ)
ECT: ECIAI39_0279(malZ)
ECZ: ECS88_0398(malZ)
EUM: ECUMN_0440(malZ) ECUMN_1005
ELF: LF82_1269(malZ)
EBL: B21_00355(malZ)
EBD: ECBD_3258
EBR: ECB_00351(malZ)
EFE: EFER_2622(malZ)
STY: STY0439(malZ)
STT: t2462(malZ)
SPT: SPA2322(malZ)
SEK: SSPA2165
SPQ: SPAB_03186
SEI: SPC_0412(malZ)
SEC: SC0443(malZ)
SEH: SeHA_C0501
SEE: SNSL254_A0446
SEW: SeSA_A0459
SEA: SeAg_B0440
SEG: SG0413(malZ)
SET: SEN0384(malZ)
SES: SARI_02085 SARI_02524
STM: STM0401(malZ)
YPE: YPO0848 YPO3200(malZ)
YPK: y0983(malZ) y3233
YPM: YP_0732(malZ) YP_3545
YPA: YPA_0422 YPA_2693
YPN: YPN_0889 YPN_3050
YPG: YpAngola_A3281
YPP: YPDSF_0666 YPDSF_2833
YPS: YPTB0922(malZ) YPTB3093
YPI: YpsIP31758_3131(malZ)
YPY: YPK_0977 YPK_3271
YPB: YPTS_0963 YPTS_3215
YEN: YE3177(malZ) YE3359
SFL: SF0340(malZ)
SFX: S0348(malZ)
SFV: SFV_0368(malZ)
SSN: SSON_0380(malZ) SSON_0800
ECA: ECA1968
ENT: Ent638_0871 Ent638_1312
ESA: ESA_02513 ESA_02709 ESA_02901
KPN: KPN_00344(malZ) KPN_00852
KPE: KPK_3714 KPK_4341(malZ)
KPU: KP1_1205(malZ) KP1_1811
CKO: CKO_02297 CKO_02764
SPE: Spro_1049 Spro_2521 Spro_3598
EIC: NT01EI_1035
MSU: MS0539
APL: APL_1021
APJ: APJL_1039
ASU: Asuc_0149
AAT: D11S_1514
XCC: XCC2468(aglA) XCC2471(aglA) XCC3163(susB)
XCB: XC_1002 XC_1642 XC_1645
XCA: xccb100_1014 xccb100_1697(aglA1) xccb100_1699
XCV: XCV2800 XCV2803(aglA) XCV3431
XAC: XAC2599(aglA) XAC2602(aglA) XAC3313(susB)
SML: Smlt1174(aglA) Smlt1176
SMT: Smal_1017 Smal_1019
VVU: VV1_2227
VVY: VV2128
VPA: VP2077
PPR: PBPRA1726 PBPRB0321
PMY: Pmen_3128
PSA: PST_0490 PST_3479
CJA: CJA_0732(glu13A)
SON: SO_2213 SO_2450(susB)
SDN: Sden_2002 Sden_2028
SFR: Sfri_1777 Sfri_1788
SAZ: Sama_1108 Sama_1662
SBL: Sbal_2287 Sbal_2329
SBM: Shew185_2039 Shew185_2329
SBN: Sbal195_2086 Sbal195_2445
SBP: Sbal223_2017 Sbal223_2299
SLO: Shew_1876 Shew_1889 Shew_2298
SPL: Spea_1628
SHE: Shewmr4_1876 Shewmr4_2133
SHM: Shewmr7_2102 Shewmr7_2209
SHN: Shewana3_1931 Shewana3_2311
SWP: swp_2453 swp_2670 swp_2676
CPS: CPS_0983 CPS_0984
PHA: PSHAa1351 PSHAa1357 PSHAa2848
PAT: Patl_2338
SDE: Sde_0590 Sde_0601 Sde_2360
PIN: Ping_2381 Ping_2529
MCA: MCA0942
HCH: HCH_00205 HCH_00480 HCH_04150
CSA: Csal_0261
MMW: Mmwyl1_0021 Mmwyl1_2088 Mmwyl1_2781
AHA: AHA_4149
ASA: ASA_0164(malZ)
RSO: RSc1081
RPI: Rpic_0948
RPF: Rpic12D_1013
BUR: Bcep18194_B1872
BCN: Bcen_4208
BCH: Bcen2424_4158
BCM: Bcenmc03_3358
BAM: Bamb_3565
VAP: Vapar_1969
EBA: ebA583
AZO: azo2310(palZ)
BBA: Bd2279(malA)
MLO: mll5109 mlr7593
MES: Meso_3687
PLA: Plav_2954
SME: SMc01532 SMc03064(aglA)
ATU: Atu0594(aglA) Atu2295(aglA)
ATC: AGR_C_1051 AGR_C_4169
ARA: Arad_0936(aglA)
RET: RHE_CH00699(aglA) RHE_CH03095(ypch01078)
REC: RHECIAT_CH0000778(aglA)
RLE: RL0748(aglA) RL3542(aglA)
RLT: Rleg2_0358
RLG: Rleg_0390
BJA: blr0901(aglA)
BRA: BRADO0511 BRADO4392
RPA: RPA4759
RPB: RPB_0810
RPC: RPC_4891
RPD: RPD_0917
RPE: RPE_4865
RPT: Rpal_5242
MRD: Mrad2831_1595
MET: M446_3077
MPO: Mpop_1988
MCH: Mchl_2303
MNO: Mnod_5268
CCR: CC_0796 CC_2285
SIT: TM1040_3304 TM1040_3867
RSP: RSP_1370
RSH: Rsph17029_0039
RSQ: Rsph17025_0029
JAN: Jann_1949 Jann_3112
RDE: RD1_2326(aglA)
DSH: Dshi_1649 Dshi_3898
MMR: Mmar10_2736 Mmar10_2740
HNE: HNE_2506
NAR: Saro_1891 Saro_1892
SAL: Sala_0184 Sala_0185
ELI: ELI_03175 ELI_03180
GOX: GOX1342
RRU: Rru_A2294
RCE: RC1_1702(aglA)
BSU: BSU31290(yugT)
BHA: BH0704 BH3868
BAN: BA0371
BAR: GBAA0371
BAA: BA_0945
BAT: BAS0357
BCE: BC0413
BCA: BCE_0481
BCZ: BCZK0343
BCR: BCAH187_A0470
BCB: BCB4264_A0427
BCU: BCAH820_0413
BCQ: BCQ_0445
BTK: BT9727_0347
BTL: BALH_0369
BWE: BcerKBAB4_0352
BLI: BL00280 BL02585(yugT)
BLD: BLi02117 BLi03301(yugT)
BCL: ABC0298
GKA: GK0615
GTN: GTNG_0528
SAU: SA1338(malA)
SAV: SAV1507(malA)
SAW: SAHV_1495(malA)
SAM: MW1461(malA)
SAR: SAR1584(malA)
SAS: SAS1447
SAC: SACOL1551(malA)
SAB: SAB1368c(malA)
SAA: SAUSA300_1456
SAX: USA300HOU_1509(malA)
SAO: SAOUHSC_01601
SAJ: SaurJH9_1564
SAH: SaurJH1_1595
SAE: NWMN_1414(malA)
SEP: SE1191
SER: SERP1070(malA)
SHA: SH1408(malA)
SSP: SSP1246
LMO: lmo0183
LMF: LMOf2365_0194
LMH: LMHCC_2460
LIN: lin0222
LLA: L128691(agl)
LLC: LACR_1848
LLM: llmg_0744(agl) llmg_1869(apu)
LPL: lp_0174(agl1) lp_0189(agl2) lp_0193(agl3) lp_3220(agl4)
lp_3534(agl5) lp_3627(agl6)
LJO: LJ0211 LJ0569
LAC: LBA1812 LBA1872
LBR: LVIS_0137 LVIS_0309 LVIS_2180
LCA: LSEI_0980 LSEI_2102
LGA: LGAS_0214 LGAS_1729
LRE: Lreu_1017
LRF: LAR_0972
EFA: EF1349
LME: LEUM_0828 LEUM_0899
CAC: CAC2891
CPE: CPE0418 CPE2076 CPE2339
CPF: CPF_0421 CPF_2333 CPF_2648
CPR: CPR_0417 CPR_2334
CNO: NT01CX_0968
CBO: CBO1604(malL)
CBA: CLB_1623
CBH: CLC_1632
CBL: CLK_1067
CBK: CLL_A0330
CBB: CLD_2950
CBT: CLH_0315
CBF: CLI_1684
CBE: Cbei_1443
DAU: Daud_0015
TTE: TTE0006 TTE1934
TEX: Teth514_0006
TPD: Teth39_0006
HOR: Hore_19090
MMY: MSC_0162(xylS)
MMO: MMOB3970(algA)
MTU: Rv2471(aglA)
MTC: MT2547
MRA: MRA_2497(aglA)
MTF: TBFG_12496
MBO: Mb2498(aglA)
MBB: BCG_2491(aglA)
MBT: JTY_2485(aglA)
MPA: MAP2292
MAV: MAV_1700
MSM: MSMEG_4696
MVA: Mvan_2546
MGI: Mflv_3849
MAB: MAB_1565c
MMC: Mmcs_3611
MKM: Mkms_3684
MJL: Mjls_3616
CDI: DIP0532
NFA: nfa13150
RHA: RHA1_ro01389 RHA1_ro04274
RER: RER_38280(aglA)
ROP: ROP_11040(aglA) ROP_41880(aglA)
SCO: SCO1394(SC1A8A.14) SCO2228(aglA) SCO3780(SCH63.27)
SCO7010(aglA)
SMA: SAV_1724(aglA1) SAV_5980(aglA2) SAV_6307(treA) SAV_6969
SGR: SGR_5278
CMI: CMM_2797(aglC)
CMS: CMS_2611
ART: Arth_0412 Arth_0743 Arth_0747 Arth_3038
AAU: AAur_0917 AAur_0921 AAur_3011
RSA: RSal33209_0147
KRH: KRH_01610(aglA)
PAC: PPA1630 PPA2332
NCA: Noca_0775
TFU: Tfu_0833
FRA: Francci3_1150
FRE: Franean1_5316
FAL: FRAAL1845(aglA)
KRA: Krad_3300 Krad_3538
SEN: SACE_1330 SACE_1668(aglA) SACE_3274(aglA) SACE_4257(aglA)
SACE_5058 SACE_6260(aglA)
STP: Strop_0801
SAQ: Sare_0745
BLO: BL0529(aglA)
BLJ: BLD_1323
BLN: Blon_0137
BAD: BAD_0971(aglA) BAD_1561(aglA)
BLA: BLA_0706(aglA)
RXY: Rxyl_2099 Rxyl_3169
LIL: LA2944
LIC: LIC11117(malZ)
LBJ: LBJ_0964
LBL: LBL_2069
ABA: Acid345_0387 Acid345_0650 Acid345_0921
SUS: Acid_3433
BTH: BT_3086
BFR: BF1397
BFS: BF1332
BVU: BVU_1381
SRU: SRU_2253(susB)
CHU: CHU_0803(malZ)
DFE: Dfer_0107
CPI: Cpin_3099 Cpin_5769
GFO: GFO_2998
FJO: Fjoh_2746 Fjoh_4326 Fjoh_4430
COC: Coch_0626
AMU: Amuc_1870
RBA: RB10507
CYA: CYA_2306
CYB: CYB_1375
CYT: cce_1458 cce_2139(malZ) cce_3484
CYC: PCC7424_0521
GVI: gll0197 glr1535
ANA: alr4773 alr5331
NPU: Npun_R2454
TER: Tery_4624
RRS: RoseRS_1931 RoseRS_3310
RCA: Rcas_3863
CAU: Caur_1536 Caur_1897
CAG: Cagg_2274 Cagg_3324
CHL: Chy400_2050
HAU: Haur_2545 Haur_3705
DRA: DR_0723 DR_1375
DGE: Dgeo_0475 Dgeo_0672
TTH: TTC0107 TTC1283 TT_P0221
TTJ: TTHA0481 TTHA1647 TTHB033
TMA: TM0434 TM0752
TME: Tmel_1611
TAF: THA_1818
FNO: Fnod_1570
PMO: Pmob_1108
KOL: Kole_0585
DTH: DICTH_0486 DICTH_1899
DTU: Dtur_0171 Dtur_0650
HMA: rrnAC0224(aglA1)
TAC: Ta0298
TVO: TVN1302
PTO: PTO0092
SSO: SSO3051(malA)
STO: ST2525
SAI: Saci_1160(malA)
SIS: LS215_2479
SIA: M1425_2307
SIM: M1627_2386
SID: M164_2309
SIY: YG5714_2444
SIN: YN1551_0466
MSE: Msed_0911
PAI: PAE1968
PIS: Pisl_1794
PCL: Pcal_0917
PAS: Pars_2044
CMA: Cmaq_1628
 |
|---|
| Structures |
PDB: 1G7P 1OBB 1VAD 2D73 2G3M 2G3N 2JKA 2JKE 2JKP 2ZE0
2ZQ0 3CTT |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5466143]
Bruni CB, Sica V, Auricchio F, Covelli I.
Further kinetic and structural characterization of the lysosomal
alpha-D-glucoside glucohydrolase from cattle liver.
Biochim. Biophys. Acta. 212 (1970) 470-7.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:29602]
Flanagan PR, Forstner GG.
Purification of rat intestinal maltase/glucoamylase and its
anomalous dissociation either by heat or by low pH.
Biochem. J. 173 (1978) 553-63.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
|
3
Larner, J.
Other glucosidases.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 4, Academic Press, New York, 1960, p. 369-378. |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:4792946]
Sivakami S, Radhakrishnan AN.
Purification of rabbit intestinal glucoamylase by affinity
chromatography on Sephadex G-200.
Indian. J. Biochem. Biophys. 10 (1973) 283-4.
Oryctolagus cuniculus |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:6814909]
Sorensen SH, Noren O, Sjostrom H, Danielsen EM.
Amphiphilic pig intestinal microvillus maltase/glucoamylase.
Structure and specificity.
Eur. J. Biochem. 126 (1982) 559-68.
Sus scofa [GN:ssc] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.2.1.20
IUBMB Enzyme Nomenclature: 3.2.1.20
ExPASy - ENZYME nomenclature database: 3.2.1.20
BRENDA, the Enzyme Database: 3.2.1.20
CAS: 9001-42-7 |
|---|
