| Entry |
|
|---|
| Name |
beta-galactosidase;
lactase (ambiguous);
beta-lactosidase;
maxilact;
hydrolact;
beta-D-lactosidase;
S 2107;
lactozym;
trilactase;
beta-D-galactanase;
oryzatym;
sumiklat |
|---|
| Class |
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl
compounds
 |
|---|
| Sysname |
beta-D-galactoside galactohydrolase |
|---|
| Reaction(IUBMB) |
Hydrolysis of terminal non-reducing beta-D-galactose residues in
beta-D-galactosides |
|---|
| Reaction(KEGG) |
(other) R01100 R01105 R01678 R03355 R04633 R04783 R05112 R05994(G)
R06010(G) R06098(G) R06099(G) R06114(G) R06144(G) R06202(G)
R07807(G)
 |
|---|
| Comment |
Some enzymes in this group hydrolyse alpha-L-arabinosides; some
animal enzymes also hydrolyse beta-D-fucosides and
beta-D-glucosides; cf. EC 3.2.1.108 lactase. |
|---|
| Pathway |
PATH: ec00052 Galactose metabolism
PATH: ec00511 Other glycan degradation
PATH: ec00531 Glycosaminoglycan degradation
PATH: ec00600 Sphingolipid metabolism
PATH: ec00604 Glycosphingolipid biosynthesis - ganglio series
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01190 beta-galactosidase
KO: K12111 evolved beta-galactosidase subunit alpha
KO: K12308 beta-galactosidase
KO: K12309 beta-galactosidase |
|---|
| Genes |
HSA: 2720(GLB1)
MCC: 709355
MMU: 12091(Glb1)
RNO: 316033(Glb1)
CFA: 403873(GLB1)
BTA: 507188(GLB1)
ECB: 100056371
MDO: 100028615
OAA: 100084405
GGA: 420720(GLB1)
TGU: 100226450
XLA: 100158367
XTR: 548712
DRE: 548343(glb1)
SPU: 587532
DME: Dmel_CG3132(Ect3) Dmel_CG9092(Gal)
DPO: Dpse_GA16177 Dpse_GA25341
DAN: Dana_GF14288 Dana_GF17225
DER: Dere_GG18564 Dere_GG24263
DPE: Dper_GL19091 Dper_GL22259
DSE: Dsec_GM17976 Dsec_GM23992
DSI: Dsim_GD18795
DYA: Dyak_GE18961 Dyak_GE26154
DGR: Dgri_GH10713 Dgri_GH23545
DMO: Dmoj_GI11295 Dmoj_GI23552
AGA: AgaP_AGAP002055
AAG: AaeL_AAEL004575 AaeL_AAEL004580 AaeL_AAEL004582
CQU: CpipJ_CPIJ003336
AME: 725756
NVI: 100119157 100119373
API: 100163383 100166809 100169081
ISC: IscW_ISCW019676
CEL: T19B10.3(beta-galactosidase)
CBR: CBG23139
SMM: Smp_011990
NVE: NEMVE_v1g161675 NEMVE_v1g167821 NEMVE_v1g237939
HMG: 100197858 100206696
ATH: AT1G72990(BGAL17) AT3G52840(BGAL2) AT3G54440
POP: POPTR_919635
RCU: RCOM_0311630
VVI: 100251499
OSA: 4325748(Os01g0952600) 4339457(Os05g0539400)
SBI: SORBI_09g026870(SORBIDRAFT_09g026870)
PPP: PHYPADRAFT_136592 PHYPADRAFT_209243
CRE: CHLREDRAFT_118013
OLU: OSTLU_119488(LacZ)
CME: CMP078C
DHA: DEHA0G26345g
PIC: PICST_30036(LAC4)
MGR: MGG_05890 MGG_11289 MGG_13801
ANI: AN3201.2 AN6388.2
AFM: AFUA_1G14170 AFUA_1G16700 AFUA_3G00380 AFUA_5G14090
AFUA_5G14550 AFUA_6G06660
AOR: AO090012000389 AO090120000158
ANG: An06g00290
DDI: DDBDRAFT_0188784
TET: TTHERM_00321550 TTHERM_00321600 TTHERM_00321640
ECO: b0344(lacZ) b3076(ebgA)
ECJ: JW0335(lacZ) JW5511(ebgA)
ECD: ECDH10B_3251(ebgA)
EBW: BWG_2786(ebgA) BWG_3744
ECE: Z0440(lacZ) Z4429(ebgA)
ECS: ECs0397(lacZ) ECs3958(ebgA)
ECF: ECH74115_0417(lacZ) ECH74115_4390(ebgA)
ETW: ECSP_0406(lacZ) ECSP_4050(ebgA)
ECG: E2348C_0299(lacZ) E2348C_3369(ebgA)
ECC: c0459(lacZ) c3833(ebgA)
ECI: UTI89_C0371(lacZ) UTI89_C3516(ebgA)
ECP: ECP_0417(lacZ) ECP_3167(ebgA)
ECV: APECO1_1649(lacZ) APECO1_3340(ebgA)
ECW: EcE24377A_0368(lacZ) EcE24377A_3543(ebgA)
ECX: EcHS_A0408(lacZ) EcHS_A3258(ebgA)
ECM: EcSMS35_0375(lacZ) EcSMS35_3370(ebgA)
ECY: ECSE_0369(lacZ) ECSE_3357(ebgA)
ECL: EcolC_0624(ebgA) EcolC_3281(lacZ)
ECK: EC55989_0351(lacZ) EC55989_3490(ebgA)
ECQ: ECED1_0372(lacZ) ECED1_3744(ebgA)
ECR: ECIAI1_0345(lacZ) ECIAI1_3223(ebgA)
ECT: ECIAI39_0334(lacZ) ECIAI39_3574(ebgA)
ECZ: ECS88_0351(lacZ) ECS88_3473(ebgA)
EUM: ECUMN_0387(lacZ) ECUMN_3559(ebgA)
ELF: LF82_0539(ebgA) LF82_1168(lacZ)
EBL: B21_00302(lacZ) B21_02895(ebgA)
EBD: ECBD_0666 ECBD_3313
EBR: ECB_00298(lacZ) ECB_02945(ebgA)
EOH: ECO103_3821(ebgA)
EOI: ECO111_3898(ebgA)
EOJ: ECO26_4177(ebgA)
EFE: EFER_2656(lacZ)
SES: SARI_02832(lacZ)
YPE: YPO0852(bgaB) YPO1654(lacZ)
YPK: y1817(lacZ) y3237
YPM: YP_1785(lacZ) YP_3549(bgaB)
YPA: YPA_0418 YPA_1868(lacZ)
YPN: YPN_1975(lacZ) YPN_3054
YPG: YpAngola_A2834(lacZ)
YPP: YPDSF_1792(lacZ)
YPS: YPTB2415(lacZ) YPTB3097(bgaB)
YPI: YpsIP31758_0918 YpsIP31758_1629(lacZ)
YPY: YPK_0973 YPK_1739(lacZ)
YPB: YPTS_2494(lacZ) YPTS_3219
YEN: YE2592(lacZ)
SFL: SF3116(ebgA)
SFX: S3323(ebgA)
SFV: SFV_3117(ebgA)
SSN: SSON_0299(lacZ) SSON_3215(ebgA)
SBO: SBO_2935(ebgA)
SDY: SDY_0378(lacZ)
ECA: ECA1490(lacZ) ECA3179(pbg)
PCT: PC1_1362 PC1_2962
PWA: Pecwa_1317 Pecwa_2635
ETA: ETA_25680(lacZ)
ENT: Ent638_0928(lacZ)
ESA: ESA_02977(lacZ) ESA_03417
CTU: Ctu_05490(ganA)
KPN: KPN_00431 KPN_01610(lacZ) KPN_04612 KPN_pKPN3p05871(lacZ)
KPE: KPK_2776(lacZ) KPK_4249(bgaB) KPK_5057
KPU: KP1_1306 KP1_2639(lacZ)
CKO: CKO_02825(lacZ)
SPE: Spro_1973(ebgA) Spro_3173(lacZ)
DDA: Dd703_1261
DDC: Dd586_2930
DZE: Dd1591_1280 Dd1591_2733
HAP: HAPS_0190(bgaC)
MSU: MS0749(lacZ) MS0806(lacZ)
APL: APL_0997(lacZ)
APJ: APJL_1014(lacZ)
APA: APP7_1050
ASU: Asuc_1398
AAP: NT05HA_0966
XFA: XF0840
XFT: PD1833(bga)
XFM: Xfasm12_2009
XFN: XfasM23_1933
XCC: XCC1256(bga) XCC2895(bga) XCC4116
XCB: XC_1214 XC_2985 XC_4208
XCA: xccb100_1257(bga2) xccb100_3047(bga3)
XCV: XCV1359 XCV3214(bga1) XCV4356(bga2)
XAC: XAC1308(bga) XAC3078(bga) XAC3084(bga) XAC4250
XOO: XOO1769(bga) XOO3923(lacZ)
XOM: XOO_1670 XOO_3703
XOP: PXO_01626
VCO: VC0395_A1917(lacZ)
VCM: VCM66_2261(lacZ)
VCJ: VCD_002010
VVU: VV1_1767(ebgA) VV2_1327(lacZ)
VVY: VV2642(ebgA) VVA0165(lacZ)
VPA: VP2403(ebgA)
VHA: VIBHAR_03337
VEX: VEA_002658
VFI: VF_A0347(ebgA)
VFM: VFMJ11_A0385(ebgA)
PPR: PBPRA2084(ebgA) PBPRB0034(lacZ)
SLO: Shew_3269
SSE: Ssed_4018
SPL: Spea_0580
SHL: Shal_0667
SWP: swp_4524
PAT: Patl_0821 Patl_2144 Patl_4065
SDE: Sde_2935 Sde_3882
AMC: MADE_00275(lacZ)
PIN: Ping_2019(lacZ)
MCA: MCA0941
FPH: Fphi_0309
MMW: Mmwyl1_2015
AHA: AHA_0205(ebgA) AHA_4101(lacZ)
ASA: ASA_2378
TAU: Tola_2910
BVI: Bcep1808_1284 Bcep1808_3827
BCN: Bcen_4877 Bcen_5202
BCH: Bcen2424_3288 Bcen2424_5657
BCM: Bcenmc03_4578
BCJ: BCAM2807(bgaB)
BAM: Bamb_4931 Bamb_6327
BAC: BamMC406_5486 BamMC406_6027
BMU: Bmul_3197
BMJ: BMULJ_05328(lacZ)
BPH: Bphy_2352 Bphy_6542
BPY: Bphyt_4585
BGL: bglu_1g17680 bglu_2g04070
LCH: Lcho_3245
SCL: sce7608
PLA: Plav_1938
SME: SM_b20966(lacZ2) SM_b21655(lacZ1)
ARA: Arad_8320(lacZ1) Arad_9044(lacZ1)
AVI: Avi_5411 Avi_5742
RET: RHE_CH02656(lacZ1) RHE_CH03705(lacZ2)
REC: RHECIAT_CH0002793(lacZ1)
RLE: RL3107(bgaB) RL3801 RL4248(lacZ)
RLT: Rleg2_2323
RLG: Rleg_2648 Rleg_3380
SIT: TM1040_3492
JAN: Jann_3830
RDE: RD1_2869(bgaT)
DSH: Dshi_1239(lacZ)
ZMO: ZMO0904
SAL: Sala_1017
ELI: ELI_03710
BSU: BSU07080(yesZ) BSU34130(ganA)
BHA: BH2022(lacA) BH2723 BH3701
BCZ: pE33L466_0350(bgaC)
BLI: BL00264(lacA) BL01749(lacA2) BL03780(yesZ)
BLD: BLi00447 BLi01382(yesZ) BLi04277(lacA)
BCL: ABC1405 ABC3516(lacA)
BPU: BPUM_3617(lacA)
GYM: GYMC10_0835 GYMC10_1195 GYMC10_2644 GYMC10_3156 GYMC10_3968
GYMC10_5609
GYC: GYMC61_0530
SSP: SSP0105
SCA: Sca_1965(lacH)
ESI: Exig_0375 Exig_1655
BBE: BBR47_58080
PJD: Pjdr2_0896 Pjdr2_1165 Pjdr2_1514 Pjdr2_1682 Pjdr2_1747
Pjdr2_5090 Pjdr2_5236
AAC: Aaci_1218 Aaci_2891
LLA: L0025(lacZ)
SPY: SPy_1586
SPZ: M5005_Spy_1304(lacZ)
SPM: spyM18_1594
SPH: MGAS10270_Spy1419(lacZ)
SPI: MGAS10750_Spy1413(lacZ)
SPJ: MGAS2096_Spy1324(lacZ)
SPK: MGAS9429_Spy1298(lacZ)
SPF: SpyM50551
SPA: M6_Spy1322
SPB: M28_Spy1345(lacZ)
SPN: SP_0060 SP_0648
SPD: SPD_0065(bgaC) SPD_0562(bgaA)
SPR: spr0059(bgaC) spr0565(bgaA)
SPW: SPCG_0061(bgaC) SPCG_0603(bgaA)
SPX: SPG_0064 SPG_0588
SNE: SPN23F_00750 SPN23F_05830(bgaA)
SPV: SPH_0166 SPH_0741
SNM: SP70585_0126 SP70585_0707
SJJ: SPJ_0090 SPJ_0596
SPP: SPP_0124 SPP_0665
SNT: SPT_0097 SPT_0670
STC: str1397(lacZ)
STL: stu1397(lacZ)
STE: STER_1366
SSA: SSA_0053 SSA_0271
SSU: SSU05_0449
SSV: SSU98_0437
SSB: SSUBM407_0390
SSI: SSU0402
SSS: SSUSC84_0387
SGO: SGO_0043 SGO_1486
SEQ: SZO_05320 SZO_12130
SEZ: Sez_0741(bga) Sez_1424(bga) Sez_1496(lacZ)
SEU: SEQ_1611
SUB: SUB0042
SDS: SDEG_0679(bga)
LPL: lp_3469(lacA) lp_3483(lacL) lp_3484(lacM)
LPJ: JDM1_2762(lacA)
LJO: LJ0738 LJ0854 LJ0855 LJ0858
LJF: FI9785_610
LAC: LBA1364(lacA) LBA1462(lacZ) LBA1467(lacL) LBA1468(lacM)
LSA: LSA1710(lacM) LSA1711(lacL)
LSL: LSL_0376(lacZ)
LDB: Ldb1201(lacZ)
LBU: LBUL_1114
LBR: LVIS_2258 LVIS_2259
LCA: LSEI_0384(ebgA)
LCB: LCABL_02910(bgaC)
LRE: Lreu_0288 Lreu_0289 Lreu_1085
LRF: LAR_1032
LHE: lhv_1542
LFE: LAF_0780
LRH: LGG_00336(bgaC) LGG_00470(ebgA)
LRL: LC705_00328(bgaC)
PPE: PEPE_0204
EFA: EF0813 EF1805 EF1851 EF2709(ebgA)
OOE: OEOE_1044(lacZ) OEOE_1831
LME: LEUM_0845 LEUM_1064 LEUM_1316(lacZ)
CAC: CAC2514
CPE: CPE0167(pbg) CPE0771(bgaL) CPE0831(bgaL)
CPF: CPF_0160 CPF_0766 CPF_1221(lacZ) CPF_1474(lacZ)
CPR: CPR_0156 CPR_0750
CBE: Cbei_1232 Cbei_1236
CCE: Ccel_1013 Ccel_2451
ATE: Athe_1927
ERE: EUBREC_1317 EUBREC_2453
TTE: TTE0061
CSC: Csac_0362 Csac_1018
ROP: ROP_55640(bga)
SCO: SCO3479(SCE65.15c) SCO5689(SC5H4.13) SCO6347(SC3A7.15)
SCO6457(SC9B5.24) SCO7407(SC6D11.03c)
SMA: SAV_1027(bga1) SAV_1325(bga2) SAV_1451(bga3) SAV_1760(bga4)
SAV_2095(bga5) SAV_2573(bga6)
SGR: SGR_5507
CMI: CMM_0355(bgaA) CMM_2109(lacZ) CMM_2700(bgaB)
CMS: CMS_1112(lacZ2) CMS_2571 CMS_2675(bga)
ART: Arth_3325 Arth_3917
AAU: AAur_1127 AAur_2821(bgaC) AAur_3310 AAur_4082
ACH: Achl_3125 Achl_3570 Achl_3719
RSA: RSal33209_0037 RSal33209_0038 RSal33209_3151
BCV: Bcav_1316 Bcav_3298 Bcav_3322 Bcav_3398
BFA: Bfae_03990 Bfae_04160 Bfae_17050
JDE: Jden_0104 Jden_0378 Jden_1764 Jden_2397
XCE: Xcel_1193 Xcel_2151
PAC: PPA1700 PPA1819
TFU: Tfu_1615
SRO: Sros_1287 Sros_3535 Sros_7453 Sros_7700
FRE: Franean1_3257
KRA: Krad_0412 Krad_3970
SEN: SACE_0306(bga) SACE_1940(lacZ2) SACE_5154(bga2) SACE_6726(lacZ)
AMI: Amir_0617 Amir_1976 Amir_2173 Amir_2576
CAI: Caci_2028 Caci_4420 Caci_4935 Caci_7101
BLO: BL0259(bgaB) BL0978(lacZ) BL1168(bga)
BLJ: BLD_0729(lacZ1) BLD_0926(lacA1) BLD_1005(lacA2)
BLN: Blon_2016 Blon_2334 Blon_2416
BAD: BAD_1402 BAD_1582 BAD_1603 BAD_1605
BLA: BLA_0044(bga) BLA_0454(lacZ) BLA_0462
BLC: Balac_0053 Balac_0484
BLT: Balat_0053 Balat_0484
LIL: LA0035
LIC: LIC10031(lacZ)
LBI: LEPBI_I0024
LBF: LBF_0026(lacA)
ABA: Acid345_0901 Acid345_4484
ACA: ACP_0072 ACP_0552 ACP_0864 ACP_1241 ACP_1346
SUS: Acid_4396 Acid_4607 Acid_7597
BTH: BT_0290 BT_0993 BT_1626 BT_3340 BT_3654 BT_4050 BT_4152 BT_4241
BFR: BF0192 BF0929 BF3244 BF3375 BF3897 BF4019
BFS: BF0029 BF0157 BF0851 BF3084 BF3205 BF3667 BF3793
BVU: BVU_0179 BVU_0301 BVU_0495 BVU_1365
PGI: PG0665(lacZ-1)
PGN: PGN_0701(lacZI)
PDI: BDI_0983 BDI_1518
CPI: Cpin_4556 Cpin_5411
GFO: GFO_1699(lacZ) GFO_1738(lacZ)
FJO: Fjoh_0779 Fjoh_2038 Fjoh_3118 Fjoh_4102
COC: Coch_0195 Coch_1009 Coch_1011 Coch_1016 Coch_1807
STR: Sterm_0715
OTE: Oter_2209 Oter_2925 Oter_3614
AMU: Amuc_0290 Amuc_0771 Amuc_0824 Amuc_1666 Amuc_1686
RBA: RB3405
RRS: RoseRS_2714
RCA: Rcas_2493
CAU: Caur_3868
CAG: Cagg_0079
CHL: Chy400_4177
HAU: Haur_2392 Haur_3638
DGE: Dgeo_2829
TTH: TT_P0220 TT_P0222
TTJ: TTHB032 TTHB034
TMA: TM0310 TM1193 TM1195
TPT: Tpet_0607 Tpet_1557 Tpet_1559
TLE: Tlet_0218 Tlet_1296
TRQ: TRQ2_0621 TRQ2_1623 TRQ2_1625
TNA: CTN_0377 CTN_1379
TNP: Tnap_0949 Tnap_1577
TAF: THA_1578
FNO: Fnod_0419
PMO: Pmob_0829
DTH: DICTH_0134(ebgA) DICTH_0381 DICTH_1786
DTU: Dtur_0081 Dtur_0505
TTR: Tter_2516 Tter_2642
HLA: Hlac_2868
HMU: Hmuk_3226
TAC: Ta1323
TVO: TVN0685
PTO: PTO1259 PTO1453
PHO: PH0501 PH0511
PAB: PAB1349 PAB1740 PAB2376(bgaL)
PFU: PF0073 PF0356 PF0363 PF1208
TKO: TK1754 TK1761
DKA: DKAM_0402
SSO: SSO3019(lacS)
STO: ST0773
SAI: Saci_1849(bgaS)
CMA: Cmaq_0080 Cmaq_0408 Cmaq_0900
TPE: Tpen_1675
 |
|---|
| Structures |
PDB: 1BGL 1BGM 1DP0 1F49 1F4A 1F4H 1GHO 1GOW 1JYN 1JYV
1JYW 1JYX 1JYY 1JYZ 1JZ0 1JZ1 1JZ2 1JZ3 1JZ4 1JZ5
1JZ6 1JZ7 1JZ8 1KWG 1KWK 1PX3 1PX4 1TG7 1UWI 1UWQ
1UWR 1UWS 1UWT 1UWU 1XC6 1YQ2 2CEQ 3CZJ 3DYM 3DYO
3DYP 3E1F 3FN9 3IAP 3IAQ |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5389663]
Blakely JA, MacKenzie SL.
Purification and properties of a beta-hexosidase from Sporobolomyces
singularis.
Can. J. Biochem. 47 (1969) 1021-5.
Sporobolomyces singularis |
|---|
Reference
Authors
Title
Journal
|
2
Kuby, S.A. and Lardy, H.A.
Purification and kinetics of beta-D-galactosidase from Escherichia
coli, strain K-12.
J. Am. Chem. Soc. 75 (1953) 890-896. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:418065]
Kuo CH, Wells WW.
beta-Galactosidase from rat mammary gland. Its purification,
properties, and role in the biosynthesis of
6beta-O-D-galactopyranosyl myo-inositol.
J. Biol. Chem. 253 (1978) 3550-6.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:13426167]
LANDMAN OE.
Properties and induction of beta-galactosidase in Bacillus
megaterium.
Biochim. Biophys. Acta. 23 (1957) 558-69.
Bacillus megaterium |
|---|
Reference
Authors
Title
Journal
|
5
Llanillo, M., Perez, N. and Cabezas, J.A.
beta-Galactosidase and beta-glucosidase activities of the same
enzyme from rabbit liver.
Int. J. Biochem. 8 (1977) 557-564. |
|---|
Reference
Authors
Title
Journal
|
6 [PMID:14943665]
MONOD J, COHN M.
[Biosynthesis induced by enzymes; enzymatic adaptation.]
Adv. Enzymol. Relat. Subj. Biochem. 13 (1952) 67-119. |
|---|
Reference
Authors
Title
|
7
Wallenfels, K. and Malhotra, O.P.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 4, Academic Press, New York, 1960, p. 409-430. |
|---|
Reference
Authors
Title
Journal
|
8 [PMID:5822067]
Asp NG, Dahlqvist A, Koldovsky O.
Human small-intestinal beta-galactosidases. Separation and
characterization of one lactase and one hetero beta-galactosidase.
Biochem. J. 114 (1969) 351-9. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.2.1.23
IUBMB Enzyme Nomenclature: 3.2.1.23
ExPASy - ENZYME nomenclature database: 3.2.1.23
BRENDA, the Enzyme Database: 3.2.1.23
CAS: 9031-11-2 |
|---|
