KEGG   ENZYME: 3.2.1.24Help
Entry
EC 3.2.1.24                 Enzyme                                 
Name alpha-mannosidase;
alpha-D-mannosidase;
p-nitrophenyl-alpha-mannosidase;
alpha-D-mannopyranosidase;
1,2-alpha-mannosidase;
1,2-alpha-D-mannosidase;
exo-alpha-mannosidase
Class Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl
compounds
BRITE hierarchy
Sysname alpha-D-mannoside mannohydrolase
Reaction(IUBMB) Hydrolysis of terminal, non-reducing alpha-D-mannose residues in
alpha-D-mannosides
Reaction(KEGG) (other) R08717(G) R08718(G)
Show
Comment Also hydrolyses alpha-D-lyxosides and heptopyranosides with the same
configuration at C-2, C-3 and C-4 as mannose.
Pathway PATH: ec00511  Other glycan degradation
Orthology KO: K01191  alpha-mannosidase
KO: K12311  lysosomal alpha-mannosidase
KO: K12312  epididymis-specific alpha-mannosidase
Genes HSA: 23324(MAN2B2) 4123(MAN2C1) 4125(MAN2B1)
MCC: 705599(MAN2C1)
MMU: 17159(Man2b1) 17160(Man2b2) 73744(Man2c1)
RNO: 246136(Man2c1) 360955(Man2b2) 361378(Man2b1)
CFA: 484932(MAN2B1) 488779(MAN2B2) 611620
BTA: 282272(MAN2B1) 523503(MAN2B2) 541086(MAN2C1) 782761
SSC: 100156538 396847(MAN2B2)
ECB: 100056382 100061610 100064359
MDO: 100010377 100019089
GGA: 415306(MAN2C1) 422859(MAN2B2)
TGU: 100228971 100229436
XLA: 431951
XTR: 100036651 100127706 779924(MGC145520)
DRE: 100003570 541519 569595
BFO: BRAFLDRAFT_287967
CIN: 100176799 100181902
SPU: 583500 591324 756277
DME: Dmel_CG4606(alpha-Man-IIb) Dmel_CG5322 Dmel_CG6206 Dmel_CG9463
     Dmel_CG9465 Dmel_CG9466 Dmel_CG9468
DPO: Dpse_GA18295 Dpse_GA21810 Dpse_GA28078 Dpse_GA28079
DAN: Dana_GF14094 Dana_GF14351 Dana_GF14352 Dana_GF14353
     Dana_GF14356 Dana_GF15795
DER: Dere_GG10384 Dere_GG23643 Dere_GG24050 Dere_GG24051
     Dere_GG24052 Dere_GG24053
DPE: Dper_GL19134 Dper_GL26214 Dper_GL26217
DSE: Dsec_GM12683 Dsec_GM12694 Dsec_GM18459
DSI: Dsim_GD22254 Dsim_GD22379 Dsim_GD22383 Dsim_GD23708
DYA: Dyak_GE10752 Dyak_GE10763 Dyak_GE10773 Dyak_GE10784
     Dyak_GE13604
DGR: Dgri_GH13617 Dgri_GH16722
DMO: Dmoj_GI13451 Dmoj_GI20521
AGA: AgaP_AGAP008584
AAG: AaeL_AAEL005749 AaeL_AAEL005752 AaeL_AAEL005763
CQU: CpipJ_CPIJ015654 CpipJ_CPIJ015656
AME: 552249
NVI: 100120019
TCA: 656843 657014
API: 100158954 100159559
ISC: IscW_ISCW012835
CEL: F55D10.1(aman-1)
CBR: CBG14532
BMY: Bm1_30540 Bm1_32610
SMM: Smp_131580
NVE: NEMVE_v1g173865 NEMVE_v1g244860
HMG: 100212242
TAD: TRIADDRAFT_63890
ATH: AT3G26720 AT5G66150
POP: POPTR_1095647 POPTR_757134 POPTR_816882
RCU: RCOM_1445250 RCOM_1503670
VVI: 100244533 100266854
OSA: 4348080(Os10g0140200) 4350617(Os11g0525600)
SBI: SORBI_01g026390(SORBIDRAFT_01g026390)
     SORBI_05g019600(SORBIDRAFT_05g019600)
ZMA: 100193937
PPP: PHYPADRAFT_136484
SCE: YGL156W(AMS1)
AGO: AGOS_AGR385C
DHA: DEHA0G18964g
PIC: PICST_35546(MLN1) PICST_83621(AMS1) PICST_84949(MNS1)
CAL: CaO19.10284(AMS1) CaO19.2768(AMS1)
CGR: CAGL0E05148g
YLI: YALI0D21890g
SPO: SPAC513.05(mns2)
NCR: NCU07404
MGR: MGG_04464
ANI: AN2936.2
AFM: AFUA_3G08200
AOR: AO090005001458
ANG: An02g11720
CNE: CNA06750
UMA: UM00557.1
DDI: DDB_0201569(manA) DDB_0231611(manG)
PTM: GSPATT00006450001 GSPATT00019586001
TBR: Tb10.70.5100
TCR: 506195.120 506407.10
TVA: TVAG_371840
PTI: PHATR_52108
ECO: b0732(mngB)
ECJ: JW0721(mngB)
SFL: SF0565(ybgG)
SFX: S0578(ybgG)
SFV: SFV_0604(ybgG)
SBO: SBO_1171
SBC: SbBS512_E0652
CKO: CKO_02413 CKO_03577
VVY: VVA1394
RET: RHE_PF00487(ypf00255)
RLE: pRL120348(ams1)
JAN: Jann_2057
DSH: Dshi_3007(ybgG)
BHA: BH0789 BH0791
GKA: GK1902
GTN: GTNG_1820 GTNG_3216
LMO: lmo0401 lmo2014 lmo2015 lmo2734
LMF: LMOf2365_0421 LMOf2365_2038 LMOf2365_2040 LMOf2365_2721
LIN: lin0424 lin2122 lin2123
LWE: lwe0365 lwe2034 lwe2035
LLA: L130682(ypdB)
SPY: SPy_1604
SPZ: M5005_Spy_1317
SPM: spyM18_1611
SPG: SpyM3_1297
SPS: SPs0564
SPH: MGAS10270_Spy1433
SPI: MGAS10750_Spy1426
SPJ: MGAS2096_Spy1338
SPK: MGAS9429_Spy1311
SPF: SpyM50538
SPA: M6_Spy1335
SPB: M28_Spy1358
SPN: SP_2143
SPD: SPD_1971
SPR: spr1951
SPW: SPCG_2113
SPV: SPH_2336
SSU: SSU05_1919
SSV: SSU98_1923
SGO: SGO_1768
LPL: lp_3631
EFA: EF1707
CPE: CPE0856 CPE1415 CPE2080
CPF: CPF_0848 CPF_2337
CPR: CPR_0841 CPR_1405 CPR_2049
CDF: CD2569 CD3085
MMY: MSC_0845
MAB: MAB_4227c
SCO: SCO0948(SCM11.03c)
SMA: SAV_1753(ama1) SAV_7277(ama2)
CMI: CMM_0347(manX) CMM_1259
ART: Arth_0803
AAU: AAur_1025
RSA: RSal33209_0512
PAC: PPA0062 PPA1459
SEN: SACE_3737(ama2)
BLO: BL1327 BL1328
BAD: BAD_1238
RXY: Rxyl_0070 Rxyl_2051
ABA: Acid345_3122
BTH: BT_3774
BFR: BF0339
BFS: BF0287
SYN: slr0323(ams1)
SYW: SYNW0267
SYC: syc2388_d(ams1)
SYF: Synpcc7942_1703
SYD: Syncc9605_0261
SYE: Syncc9902_2083
SYG: sync_0308
SYR: SynRCC307_2336
SYX: SynWH7803_0311
SYP: SYNPCC7002_A1252(ams1)
TEL: tll0290
MAR: MAE_36540
CYT: cce_1203
CYP: PCC8801_2444
CYC: PCC7424_4232
CYN: Cyan7425_3665
CYH: Cyan8802_3666
GVI: glr0080
ANA: all0848
NPU: Npun_F4313
AVA: Ava_4452
PMT: PMT1839(ams1)
PMF: P9303_24641
TER: Tery_3192
AMR: AM1_6392
CAU: Caur_1109
TMA: TM1231 TM1851
TPT: Tpet_0948 Tpet_1538
TLE: Tlet_0117
TRQ: TRQ2_0965
TNA: CTN_0786
TME: Tmel_1011
TAF: THA_1290
FNO: Fnod_0811
PMO: Pmob_0722
DTU: Dtur_1758
TVO: TVN0209
PTO: PTO0091
PHO: PH0835
SMR: Smar_0014 Smar_1142
SSO: SSO3006
STO: ST1008
CMA: Cmaq_0104 Cmaq_1289
TPE: Tpen_1628
Taxonomy
Structures PDB: 1FO2  1FO3  1O7D  
Reference
  Authors
  Title


  Journal
  Organism
 1  [PMID:5905120]
Li YT.
Presence of alpha-D-mannosidic linkage in glycoproteins. Liberation
of d-mannose from various glycoproteins by alpha-mannosidase
isolated from jack bean meal.
J. Biol. Chem. 241 (1966) 1010-2.
Canavalia ensiformis
Reference
  Authors
  Title

  Journal
 2  [PMID:6428944]
Winchester B.
Role of alpha-D-mannosidases in the biosynthesis and catabolism of
glycoproteins.
Biochem. Soc. Trans. 12 (1984) 522-4.
Other DBs ExplorEnz - The Enzyme Database: 3.2.1.24
IUBMB Enzyme Nomenclature: 3.2.1.24
ExPASy - ENZYME nomenclature database: 3.2.1.24
BRENDA, the Enzyme Database: 3.2.1.24
CAS: 9025-42-7
DBGET integrated database retrieval system