KEGG   ENZYME: 3.2.1.33Help
Entry
EC 3.2.1.33                 Enzyme                                 

Name
amylo-alpha-1,6-glucosidase;
amylo-1,6-glucosidase;
dextrin 6-alpha-D-glucosidase;
amylopectin 1,6-glucosidase;
dextrin-1,6-glucosidase;
glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
glycogen phosphorylase-limit dextrin 6-alpha-glucohydrolase
Reaction(IUBMB)
Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin
Reaction(KEGG)
(other) R02109 R06158(G)
Show
Comment
This enzyme hydrolyses an unsubstituted (1->4)-linked glucose chain. The enzyme activity found in mammals and yeast is in a polypeptide chain containing two active centres. The other activity is similar to that of EC 2.4.1.25 (4-alpha-glucanotransferase), which acts on the glycogen phosphorylase limit dextrin chains to expose the single glucose residues, which the 6-alpha-glucosidase activity can then hydrolyse. Together, these two activities constitute the glycogen debranching system.
History
EC 3.2.1.33 created 1965, modified 2000
Pathway
Starch and sucrose metabolism
Orthology
K01196  
glycogen debranching enzyme
Genes
HSA: 
178(AGL)
PTR: 
469392(AGL)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
710910(AGL)
MCF: 
CJC: 
MMU: 
77559(Agl)
RNO: 
362029(Agl)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
479931(AGL)
AML: 
UMR: 
FCA: 
PTG: 
BTA: 
517397(AGL)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
MGP: 
APLA: 
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
DRE: 
567798(agla)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
411488(GB18372)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
HMG: 
SCE: 
YPR184W(GDB1)
AGO: 
ERC: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A15250(NCAS0A15250)
NDI: 
NDAI_0J00180(NDAI0J00180)
TPF: 
TPHA_0I03290(TPHA0I03290)
TBL: 
TBLA_0J00110(TBLA0J00110)
TDL: 
TDEL_0H00300(TDEL0H00300)
KAF: 
KAFR_0B00300(KAFR0B00300)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CaO19.744(GDB1) CaO19.8363(GDB1)
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
NTE: 
NEUTE1DRAFT149613(NEUTE1DRAFT_149613)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1548174(AO090005000884)
ANG: 
ANI_1_788014(An01g06120)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
CNE: 
CNB: 
CGI: 
TMS: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT118950(AGABI1DRAFT_118950)
ABV: 
AGABI2DRAFT206172(AGABI2DRAFT_206172)
CPUT: 
SLA: 
UMA: 
PFP: 
PGR: 
MLR: 
MBR: 
DDI: 
DPP: 
DFA: 
EHI: 
EHI_098360(77.t00009)
TGO: 
TET: 
PTM: 
TVA: 
 » show all
Taxonomy
Reference
1
  Authors
Brown, D.H. and Brown, B.I.
  Title
Enzymes of glycogen debranching: Amylo-1,6-glucosidase (I) and oligo-1,4->1,4-glucanotransferase (II).
  Journal
Methods Enzymol. 8 (1966) 515-524.
Reference
2  [PMID:5424210]
  Authors
Lee EY, Carter JH, Nielsen LD, Fischer EH.
  Title
Purification and properties of yeast amylo-1,6-glucosidase--oligo-1,4 leads to 1,4-glucantransferase.
  Journal
Biochemistry. 9 (1970) 2347-55.
Reference
3  [PMID:5805288]
  Authors
Nelson TE, Kolb E, Larner J.
  Title
Purification and properties of rabbit muscle amylo-1,6-glucosidase-oligo-1,4-1,4-transferase.
  Journal
Biochemistry. 8 (1969) 1419-28.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9012-47-9

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