| Entry |
|
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| Name |
amylo-alpha-1,6-glucosidase;
amylo-1,6-glucosidase;
dextrin 6-alpha-D-glucosidase;
amylopectin 1,6-glucosidase;
dextrin-1,6-glucosidase;
glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase |
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| Class |
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl
compounds
 |
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| Sysname |
glycogen phosphorylase-limit dextrin 6-alpha-glucohydrolase |
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| Reaction(IUBMB) |
Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen
phosphorylase limit dextrin |
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| Reaction(KEGG) |
(other) R02109 R06158(G)
 |
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| Comment |
This enzyme hydrolyses an unsubstituted (1->4)-linked glucose chain.
The enzyme activity found in mammals and yeast is in a polypeptide
chain containing two active centres. The other activity is similar
to that of EC 2.4.1.25 (4-alpha-glucanotransferase), which acts on
the glycogen phosphorylase limit dextrin chains to expose the single
glucose residues, which the 6-alpha-glucosidase activity can then
hydrolyse. Together, these two activities constitute the glycogen
debranching system. |
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| Pathway |
PATH: ec00500 Starch and sucrose metabolism |
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| Orthology |
KO: K01196 amylo-1,6-glucosidase |
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| Genes |
HSA: 178(AGL)
PTR: 469392(AGL)
MCC: 710910
MMU: 77559(Agl)
RNO: 362029(Agl)
CFA: 479931(AGL)
BTA: 517397(AGL)
ECB: 100050695(AGL)
MDO: 100032952
OAA: 100081547
GGA: 424474(AGL)
TGU: 100217722
DRE: 567798(agl)
BFO: BRAFLDRAFT_70494
CIN: 100181714
DME: Dmel_CG9485
DPO: Dpse_GA21822
DAN: Dana_GF12811
DER: Dere_GG22109
DPE: Dper_GL11337
DSE: Dsec_GM15830
DSI: Dsim_GD11587
DYA: Dyak_GE12190
DGR: Dgri_GH20640
DMO: Dmoj_GI19003
AGA: AgaP_AGAP001200
AAG: AaeL_AAEL009838
CQU: CpipJ_CPIJ013040 CpipJ_CPIJ020026
AME: 411488
NVI: 100117168
TCA: 662526
API: 100159564
ISC: IscW_ISCW022516
CEL: R06A4.8
BMY: Bm1_19030
SMM: Smp_007640
HMG: 100212805
SCE: YPR184W(GDB1)
AGO: AGOS_AEL276C
KLA: KLLA0B03399g
LTH: KLTH0A00726g
PPA: PAS_chr2-2_0437
VPO: Kpol_1013p31
LEL: LELG_04604
ZRO: ZYRO0D00946g
CTP: CTRG_03951
CDU: CD36_44790
CGR: CAGL0G09977g
YLI: YALI0A19074g
PAN: PODANSg09886
MGR: MGG_00063
FGR: FG09704.1
AFM: AFUA_1G02140
AOR: AO090005000884
ANG: An01g06120
AFV: AFLA_081340
PCS: Pc22g22120
NFI: NFIA_022510
CIM: CIMG_09981
URE: UREG_06030
SSL: SS1G_12795
BFU: BC1G_05278
CNE: CNJ03090
CNB: CNBJ0440
LBC: LACBIDRAFT_302750
MPR: MPER_03030 MPER_11198
UMA: UM03949.1
MBR: MONBRDRAFT_27381
DDI: DDB_0234114(agl)
EHI: EHI_098360
EDI: EDI_161640
CPV: cgd6_880
TGO: TGME49_026910
PTM: GSPATT00032669001
GLA: GL50803_10885
TVA: TVAG_330630
VFI: VF_2048
BML: BMA10229_0038
BMN: BMA10247_A1583
BPL: BURPS1106A_A0852
BPD: BURPS668_A0945
BVI: Bcep1808_3315
BCH: Bcen2424_4932
BXE: Bxe_B1135
RPE: RPE_1189
 |
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Reference
Authors
Title
Journal
|
1
Brown, D.H. and Brown, B.I.
Enzymes of glycogen debranching: Amylo-1,6-glucosidase (I) and
oligo-1,4->1,4-glucanotransferase (II).
Methods Enzymol. 8 (1966) 515-524. |
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Reference
Authors
Title
Journal
Organism
|
2 [PMID:5424210]
Lee EY, Carter JH, Nielsen LD, Fischer EH.
Purification and properties of yeast
amylo-1,6-glucosidase--oligo-1,4 leads to 1,4-glucantransferase.
Biochemistry. 9 (1970) 2347-55.
Saccharomyces cerevisiae [GN:sce] |
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Reference
Authors
Title
Journal
Organism
|
3 [PMID:5805288]
Nelson TE, Kolb E, Larner J.
Purification and properties of rabbit muscle
amylo-1,6-glucosidase-oligo-1,4-1,4-transferase.
Biochemistry. 8 (1969) 1419-28.
Oryctolagus cuniculus |
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| Other DBs |
ExplorEnz - The Enzyme Database: 3.2.1.33
IUBMB Enzyme Nomenclature: 3.2.1.33
ExPASy - ENZYME nomenclature database: 3.2.1.33
BRENDA, the Enzyme Database: 3.2.1.33
CAS: 9012-47-9 |
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