KEGG   ENZYME: 3.2.1.35Help
Entry
EC 3.2.1.35                 Enzyme                                 
Name
hyaluronoglucosaminidase;
hyaluronidase;
hyaluronoglucosidase;
chondroitinase;
chondroitinase I
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
hyaluronate 4-glycanohydrolase
Reaction(IUBMB)
Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate
Reaction(KEGG)
(other) R07824(G) R07825(G)
Show
Comment
Also hydrolyses 1,4-beta-D-glycosidic linkages between N-acetyl-galactosamine or N-acetylgalactosamine sulfate and glucuronic acid in chondroitin, chondroitin 4- and 6-sulfates, and dermatan.
Pathway
Glycosaminoglycan degradation
Metabolic pathways
Orthology
K01197  
hyaluronoglucosaminidase
Genes
HSA: 
23553(HYAL4) 3373(HYAL1) 6677(SPAM1) 8372(HYAL3) 8692(HYAL2)
PTR: 
460389(HYAL3) 460390(HYAL1) 460391(HYAL2) 472497(HYAL4) 472498(SPAM1) 738764
PPS: 
GGO: 
101123816(HYAL2) 101150470 101150849(SPAM1) 101151269(HYAL1) 101152349(HYAL3)
PON: 
100453650(HYAL2) 100455010(HYAL1) 100455370(HYAL3) 100458070(HYAL4) 100462117(SPAM1)
MCC: 
696128(HYAL4) 696249(SPAM1) 696805 702484(HYAL2) 702850(HYAL1)
MMU: 
109685(Hyal3) 15586(Hyal1) 15587(Hyal2) 20690(Spam1) 74409(Hyal6) 74468(Hyal5) 77042(Hyal4)
RNO: 
117037(Spam1) 300993(Hyal3) 367166(Hyal1) 404783(Hyal4) 500051(Hyal6) 500052(Hyal5) 64468(Hyal2)
CFA: 
475211(SPAM1) 475212(HYAL4) 484760(HYAL2) 608602(HYAL1) 608620(HYAL3) 609321
AML: 
FCA: 
101092920(HYAL3) 101093011 101093422(HYAL1) 101094000(HYAL2) 101095484 101095731(SPAM1)
BTA: 
281838(HYAL2) 353352(SPAM1) 509761 515397(HYAL1) 518161 527125 616562(HYAL3)
SSC: 
100512820 100524837(HYAL4) 397074(SPAM-1) 404696(HYAL3) 404697(HYAL2) 404698(HYAL1)
ECB: 
100051243(SPAM1) 100056514(HYAL4) 100061845(HYAL2) 100061875(HYAL1) 100061939(HYAL3)
MDO: 
100016989 100017029(HYAL4) 100017190 100028570 100028614 100028633 100031013
SHR: 
100915487(HYAL3) 100916272 100916534(HYAL2) 100920054 100925107 100926676(SPAM1)
OAA: 
100076503 100076538(HYAL4) 100076578 100078017
GGA: 
100859903 415908(HYAL2) 417749(SPAM1) 426739(HYAL1) 770096(HYALP1)
MGP: 
100541798 100541954 100542084 100542238
TGU: 
100219184(HYAL1) 100224131 100228780(HYAL2) 100229824(SPAM1)
ACS: 
100563395 100563785 100563983 100567658(hyal4) 100567856
XLA: 
380470(hyal2-b) 398285(spam1)
XTR: 
100037890(hyal4) 100144942(hyal2) 100486024 100498156
DRE: 
100004557(hyal3) 100149853 100330444 559228(hyal2) 567869 791189(hyal6)
TRU: 
101068133 101071886 101072113 101072276 101072329 101074427 101074654
OLA: 
101155189 101155920 101159583 101169103 101170178 101170425
BFO: 
BRAFLDRAFT_127473 BRAFLDRAFT_67473
CIN: 
100186831
SPU: 
582946 584769
AGA: 
AgaP_AGAP011479
AAG: 
AaeL_AAEL013576
CQU: 
CpipJ_CPIJ019980
AME: 
406146
TCA: 
661685
API: 
100166159
PHU: 
Phum_PHUM286990 Phum_PHUM287000
CBR: 
CBG00535
NVE: 
NEMVE_v1g33467
XCC: 
XCC2028
XCB: 
XC_2155
XCA: 
xccb100_2329
XCV: 
XCV4043
XCP: 
XCR_2312
XAC: 
XAC3928
XAX: 
XACM_3822
XAO: 
XAC29_19935
XOO: 
XOO0215
XOM: 
XOO_0189
XOP: 
PXO_03654
XOR: 
XOC_4258
XCI: 
XCAW_00349
AEX: 
Astex_2731
BBE: 
BBR47_17990
PPY: 
PPE_00341
PPM: 
PPSC2_c0392
PPO: 
PPM_0365(hyl)
PTA: 
HPL003_09490
SPY: 
SPy_0701(hylP1) SPy_1600
SPZ: 
M5005_Spy_1314(hyl) M5005_Spy_1423
SPYM: 
M1GAS476_1381(hyl) M1GAS476_1502
SPM: 
spyM18_0770(hylP) spyM18_1606(hyl)
SPG: 
SpyM3_1214(hylP.4) SpyM3_1294(hyl)
SPS: 
SPs0567 SPs0648
SPH: 
MGAS10270_Spy0590 MGAS10270_Spy1310 MGAS10270_Spy1430(hyl)
SPI: 
MGAS10750_Spy0615 MGAS10750_Spy1285 MGAS10750_Spy1423(hyl)
SPJ: 
MGAS2096_Spy0593 MGAS2096_Spy1334(hyl) MGAS2096_Spy1449
SPK: 
MGAS9429_Spy0586 MGAS9429_Spy0843 MGAS9429_Spy1308(hyl) MGAS9429_Spy1425
SPF: 
SpyM50524 SpyM50541 SpyM50680 SpyM51031 SpyM51271
SPA: 
M6_Spy0059 M6_Spy0993 M6_Spy1203 M6_Spy1332 M6_Spy1348 M6_Spy1550
SPB: 
M28_Spy0977 M28_Spy1233 M28_Spy1355(hyl)
STG: 
MGAS15252_1199
SOZ: 
Spy49_1236c(hyl)
STZ: 
SPYALAB49_000995 SPYALAB49_001176 SPYALAB49_001292 SPYALAB49_001308
STX: 
MGAS1882_1115 MGAS1882_1260
SPYA: 
A20_1348c(hyl) A20_1471c
SEQ: 
SZO_04490
SEZ: 
Sez_1507(hylZ)
SEZO: 
SeseC_02032(hya)
SEU: 
SEQ_1693 SEQ_2045
SDS: 
SDEG_1588(hyl)
SDG: 
SDE12394_08290
SDA: 
GGS_1455(hyl)
SDC: 
SDSE_1739(hyl)
STK: 
STP_1213 STP_1214
EFU: 
HMPREF0351_12988(hyl)
CML: 
BN424_3212(metG)
CPE: 
CPE0191(nagH) CPE0881(nagI) CPE1234(nagJ) CPE1279(nagK) CPE1523(nagL)
CPF: 
CPF_0184(nagH) CPF_0875 CPF_1442 CPF_1487
CPR: 
CPR_1248
DED: 
DHBDCA_p2011
DEC: 
DCF50_p2023
APR: 
Apre_0148
TTO: 
Thethe_01898
TSH: 
Tsac_2289
SSG: 
Selsp_1425
SRI: 
SELR_08510
MCD: 
MCRO_0688(nagH)
MCY: 
MCYN_0715(MCYN0715)
SGR: 
SGR_4877
SSX: 
SACTE_2080
SVL: 
Strvi_5205 Strvi_7941
SFA: 
Sfla_1448 Sfla_4228
SBH: 
SBI_00159 SBI_07080
SVE: 
SVEN_2438
SALB: 
XNR_2089 XNR_4292
STRP: 
F750_2484 F750_5429
SFI: 
SFUL_2231
KSK: 
KSE_54890
PAD: 
TIIST44_11080
KFL: 
Kfla_3229
SEN: 
SACE_7066
SNA: 
Snas_2451
BBI: 
BBIF_1461
BBP: 
BBPR_1514
BBF: 
BBB_1496(nagH)
BTH: 
BT_4395
BFR: 
BF4022
BFS: 
BF3796
BFG: 
BF638R_3871
BVU: 
BVU_2069
BHL: 
Bache_1389 Bache_2906
PDI: 
BDI_1142
PMZ: 
HMPREF0659_A5046
PDN: 
HMPREF9137_0590
CPI: 
Cpin_5708
CCM: 
Ccan_17870
ZPR: 
ZPR_3254
ORH: 
Ornrh_0573
AMU: 
Amuc_0052
DPD: 
Deipe_0032
PMO: 
Pmob_0472
KOL: 
Kole_1175
MPG: 
Theba_0994
TTR: 
Tter_0116
 » show all
Taxonomy
Reference
1
  Authors
Meyer, K., Hoffman, P. and Linker, A.
  Title
Hyaluronidases.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 4, Academic Press, New York, 1960, p. 447-460.
Reference
2
  Authors
Rapport, M.M., Myer, K. and Linker, A.
  Title
Analysis of the products formed on hydrolysis of hyaluronic acid by testicular hyaluronidase.
  Journal
J. Am. Chem. Soc. 73 (1951) 2416-2420.
Reference
3  [PMID:13271353]
  Authors
WEISSMANN B.
  Title
The transglycosylative action of testicular hyaluronidase.
  Journal
J. Biol. Chem. 216 (1955) 783-94.
  Organism
Bos taurus [GN:bta]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37326-33-3
DBGET integrated database retrieval system