| Entry |
|
|---|
| Name |
hyaluronoglucosaminidase;
hyaluronidase;
hyaluronoglucosidase;
chondroitinase;
chondroitinase I |
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| Class |
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl
compounds
 |
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| Sysname |
hyaluronate 4-glycanohydrolase |
|---|
| Reaction(IUBMB) |
Random hydrolysis of (1->4)-linkages between
N-acetyl-beta-D-glucosamine and D-glucuronate residues in
hyaluronate |
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| Reaction(KEGG) |
(other) R07824(G) R07825(G)
 |
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| Comment |
Also hydrolyses 1,4-beta-D-glycosidic linkages between
N-acetyl-galactosamine or N-acetylgalactosamine sulfate and
glucuronic acid in chondroitin, chondroitin 4- and 6-sulfates, and
dermatan. |
|---|
| Pathway |
PATH: ec00531 Glycosaminoglycan degradation
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K01197 hyaluronoglucosaminidase |
|---|
| Genes |
HSA: 23553(HYAL4) 3373(HYAL1) 6677(SPAM1) 8372(HYAL3) 8692(HYAL2)
PTR: 460390(HYAL1) 460391(HYAL2) 472497(HYAL4) 472498(SPAM1) 738764
MCC: 696128 696249(SPAM1) 696805 702484(HYAL2) 702850(HYAL1)
MMU: 109685(Hyal3) 15586(Hyal1) 15587(Hyal2) 20690(Spam1)
74409(Hyal6) 74468(Hyal5) 77042(Hyal4)
RNO: 117037(Spam1) 300993(Hyal3) 367166(Hyal1) 404783(Hyal4)
500051(Hyal6) 500052(Hyal5) 64468(Hyal2)
CFA: 475211(SPAM1) 475212(HYAL4) 484760(HYAL2) 608602(HYAL1)
608620(HYAL3) 609321
BTA: 281838(HYAL2) 353352(SPAM1) 509761(SPAM1) 515397(HYAL1) 527125
616562(HYAL3)
SSC: 397074(SPAM-1) 404696(HYAL3) 404697(HYAL2) 404698(HYAL1)
ECB: 100051243 100056514 100061845 100061875(HYAL1) 100061939(HYAL3)
MDO: 100016989 100017029 100017190 100028570 100028614 100028633
100031013
OAA: 100076503 100076538 100076578 100078017
GGA: 415908(HYAL2) 417749(SPAM1) 426739(HYAL1) 770096(HYAL4)
TGU: 100219184 100224131 100228780 100229824
XLA: 380470(hyal2) 398285
XTR: 100037890 100144942
DRE: 100004557(DKEY-20D21.13) 100149853 559228(hyal2) 567869 791189
BFO: BRAFLDRAFT_67473
CIN: 100186831
SPU: 584769
DME: Dmel_CG5871
AGA: AgaP_AGAP011479
AAG: AaeL_AAEL013576
CQU: CpipJ_CPIJ019980
TCA: 661685
API: 100166159
CBR: CBG00535
NVE: NEMVE_v1g33467
XCC: XCC2028
XCB: XC_2155
XCA: xccb100_2329
XCV: XCV4043
XAC: XAC3928
XOO: XOO0215
XOM: XOO_0189
XOP: PXO_03654
BBE: BBR47_17990
SPY: SPy_0701(hylP1) SPy_1600
SPZ: M5005_Spy_1314(hyl) M5005_Spy_1423
SPM: spyM18_0770(hylP) spyM18_1606(hyl)
SPG: SpyM3_1214(hylP.4) SpyM3_1294(hyl)
SPS: SPs0567 SPs0648
SPH: MGAS10270_Spy0590 MGAS10270_Spy1310 MGAS10270_Spy1430(hyl)
SPI: MGAS10750_Spy0615 MGAS10750_Spy1285 MGAS10750_Spy1423(hyl)
SPJ: MGAS2096_Spy0593 MGAS2096_Spy1334(hyl) MGAS2096_Spy1449
SPK: MGAS9429_Spy0586 MGAS9429_Spy0843 MGAS9429_Spy1308(hyl)
MGAS9429_Spy1425
SPF: SpyM50524 SpyM50541 SpyM50680 SpyM51031
SPA: M6_Spy0059 M6_Spy0993 M6_Spy1203 M6_Spy1332 M6_Spy1348
M6_Spy1550
SPB: M28_Spy1233 M28_Spy1355(hyl)
SOZ: Spy49_1236c(hyl)
SEQ: SZO_04490
SEZ: Sez_1507(hylZ)
SEU: SEQ_1693 SEQ_2045
SDS: SDEG_1588(hyl)
CPE: CPE0191(nagH) CPE0881(nagI) CPE1234(nagJ) CPE1279(nagK)
CPE1523(nagL)
CPF: CPF_0184(nagH) CPF_0875 CPF_1442 CPF_1487
CPR: CPR_1248
APR: Apre_0148
SGR: SGR_4877
SEN: SACE_7066
BTH: BT_4395
BFR: BF4022
BFS: BF3796
BVU: BVU_2069
PDI: BDI_1142
CPI: Cpin_5708
AMU: Amuc_0052
PMO: Pmob_0472
KOL: Kole_1175
TTR: Tter_0116
 |
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| Structures |
PDB: 1FCQ 1FCU 1FCV 2ATM 2CBI 2CBJ 2J88 2JNK 2PE4 2VUR
2W1Q 2W1S 2W1U 2WB5 2WDB 2WH7 |
|---|
Reference
Authors
Title
Journal
|
1
Meyer, K., Hoffman, P. and Linker, A.
Hyaluronidases.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 4, Academic Press, New York, 1960, p. 447-460. |
|---|
Reference
Authors
Title
Journal
|
2
Rapport, M.M., Myer, K. and Linker, A.
Analysis of the products formed on hydrolysis of hyaluronic acid by
testicular hyaluronidase.
J. Am. Chem. Soc. 73 (1951) 2416-2420. |
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Reference
Authors
Title
Journal
Organism
|
3 [PMID:13271353]
WEISSMANN B.
The transglycosylative action of testicular hyaluronidase.
J. Biol. Chem. 216 (1955) 783-94.
Bos taurus [GN:bta] |
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| Other DBs |
ExplorEnz - The Enzyme Database: 3.2.1.35
IUBMB Enzyme Nomenclature: 3.2.1.35
ExPASy - ENZYME nomenclature database: 3.2.1.35
BRENDA, the Enzyme Database: 3.2.1.35
CAS: 37326-33-3 |
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