KEGG   ENZYME: 3.2.1.45Help
Entry
EC 3.2.1.45                 Enzyme                                 
Name glucosylceramidase;
psychosine hydrolase;
glucosphingosine glucosylhydrolase;
GlcCer-beta-glucosidase;
beta-D-glucocerebrosidase;
glucosylcerebrosidase;
beta-glucosylceramidase;
ceramide glucosidase;
glucocerebrosidase;
glucosylsphingosine beta-glucosidase;
glucosylsphingosine beta-D-glucosidase
Class Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl
compounds
BRITE hierarchy
Sysname D-glucosyl-N-acylsphingosine glucohydrolase
Reaction(IUBMB) D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine
[RN:R01498]
Reaction(KEGG) R01498
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Substrate D-glucosyl-N-acylsphingosine [CPD:C01190];
H2O [CPD:C00001]
Product D-glucose [CPD:C00031];
N-acylsphingosine [CPD:C00195]
Comment Also acts on glucosylsphingosine (cf. EC 3.2.1.62
glycosylceramidase).
Pathway PATH: ec00511  Other glycan degradation
PATH: ec00600  Sphingolipid metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01201  glucosylceramidase
Genes HSA: 2629(GBA)
PTR: 449571(GBA)
MCC: 715674
MMU: 14466(Gba)
RNO: 684536(Gba)
CFA: 612206(GBA)
BTA: 537087(GBA)
SSC: 449572(GBA)
ECB: 100063514
MDO: 100022104
TGU: 100226768
XLA: 447570
DRE: 559072
BFO: BRAFLDRAFT_85797
CIN: 100183961 100185182
SPU: 582024 589647 592425 594677
DME: Dmel_CG31148 Dmel_CG31414
DPO: Dpse_GA16046 Dpse_GA26980
DAN: Dana_GF16253 Dana_GF16254
DER: Dere_GG11218 Dere_GG11220
DPE: Dper_GL13654 Dper_GL13655
DSE: Dsec_GM26520 Dsec_GM26522
DSI: Dsim_GD21027
DYA: Dyak_GE10384 Dyak_GE10386
DGR: Dgri_GH17457 Dgri_GH17458
DMO: Dmoj_GI22782 Dmoj_GI22783
AGA: AgaP_AGAP001649
AAG: AaeL_AAEL014321
CQU: CpipJ_CPIJ005343
AME: 409708 409709
TCA: 664516 664560 664563 664564
API: 100167276
ISC: IscW_ISCW006884
CEL: C33C12.3(glucosylceramidase) C33C12.8(glucosylceramidase)
     Y4C6B.6
CBR: CBG00434 CBG17050 CBG17056 CBG19964
BMY: Bm1_32350
NVE: NEMVE_v1g168783
TAD: TRIADDRAFT_22822
RCU: RCOM_1857010 RCOM_1936910
NCR: NCU04395
PAN: PODANSg1943
AFM: AFUA_8G07120
ANG: An03g00500
PCS: Pc22g13580
NFI: NFIA_099910
LBC: LACBIDRAFT_317672
MPR: MPER_12194
ECQ: ECED1_0305(srfJ)
SPQ: SPAB_05573
SEA: SeAg_B4708
STM: STM4426(srfJ)
PLU: plu2272
XCC: XCC1077(srfJ)
XCB: XC_3172
XCA: xccb100_3269
XCV: XCV1202
XAC: XAC1176(srfJ)
CJA: CJA_3306(gly30A)
CPS: CPS_3714
SDE: Sde_2994
BPL: BURPS1106A_1087
BPR: GBP346_A1079
RFR: Rfer_1106
SCL: sce1832(srfJ)
HOH: Hoch_6250
CCR: CC_1757
CCS: CCNA_01833
CAK: Caul_2067
BAY: RBAM_019350
GYM: GYMC10_0229
PJD: Pjdr2_0476 Pjdr2_0477
LBR: LVIS_2226
LRL: LC705_00049
CBO: CBO1200
CBA: CLB_1230
CBH: CLC_1242
CBY: CLM_1353
CBL: CLK_0638
CBB: CLD_3368
CBI: CLJ_B1240
CBF: CLI_1283
CBE: Cbei_4675
CPY: Cphy_0858 Cphy_3404
CCE: Ccel_0649
ATE: Athe_0097
TTE: TTE2348 TTE2349
CSC: Csac_2513
HOR: Hore_04190
ACL: ACL_0726
SMA: SAV_2709
SGR: SGR_6911
SEN: SACE_4785
CAI: Caci_7221
BAD: BAD_1208
BLA: BLA_0043 BLA_0619
BLC: Balac_0052 Balac_1418
BLT: Balat_0052 Balat_1418
ABA: Acid345_4153
ACA: ACP_1970
SUS: Acid_2638
BTH: BT_3312
BVU: BVU_0498 BVU_2170
PDI: BDI_1787 BDI_3785
DFE: Dfer_5601
CPI: Cpin_3590 Cpin_6735 Cpin_6736
COC: Coch_0445
OTE: Oter_1268 Oter_1287
FNO: Fnod_0296
Taxonomy
Structures PDB: 1OGS  1Y7V  2F61  2J25  2NSX  2NT0  2NT1  2V3D  2V3E  2V3F  
     2VT0  2WCG  2WKL  3GXD  3GXF  3GXI  3GXM  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:14253443]
BRADY RO, KANFER J, SHAPIRO D.
THE METABOLISM OF GLUCOCEREBROSIDES. I. PURIFICATION AND PROPERTIES
OF A GLUCOCEREBROSIDE-CLEAVING ENZYME FROM SPLEEN TISSUE.
J. Biol. Chem. 240 (1965) 39-43.
Homo sapiens [GN:hsa]
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:3967661]
Vaccaro AM, Muscillo M, Suzuki K.
Characterization of human glucosylsphingosine glucosyl hydrolase and
comparison with glucosylceramidase.
Eur. J. Biochem. 146 (1985) 315-21.
Homo sapiens [GN:hsa]
Other DBs ExplorEnz - The Enzyme Database: 3.2.1.45
IUBMB Enzyme Nomenclature: 3.2.1.45
ExPASy - ENZYME nomenclature database: 3.2.1.45
BRENDA, the Enzyme Database: 3.2.1.45
CAS: 37228-64-1
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