KEGG   ENZYME: 3.2.1.46Help
Entry
EC 3.2.1.46                 Enzyme                                 
Name
galactosylceramidase;
cerebroside galactosidase;
galactocerebroside.beta-galactosidase;
galactosylcerebrosidase;
galactocerebrosidase;
ceramide galactosidase;
galactocerebroside galactosidase;
galactosylceramide.beta-galactosidase;
cerebroside beta-galactosidase;
galactosylceramidase I;
beta-galactosylceramidase;
galactocerebroside-beta-D-galactosidase;
lactosylceramidase I;
beta-galactocerebrosidase;
lactosylceramidase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
D-galactosyl-N-acylsphingosine galactohydrolase
Reaction(IUBMB)
a D-galactosyl-N-acylsphingosine + H2O = D-galactose + a ceramide [RN:R03617]
Reaction(KEGG)
Substrate
D-galactosyl-N-acylsphingosine [CPD:C02686];
H2O [CPD:C00001]
Product
D-galactose [CPD:C00124];
ceramide [CPD:C00195]
Comment
cf. EC 3.2.1.62 glycosylceramidase.
Pathway
Sphingolipid metabolism
Metabolic pathways
Orthology
K01202  
galactosylceramidase
Genes
HSA: 
2581(GALC)
PTR: 
736519(GALC)
PPS: 
100986325(GALC)
GGO: 
101137325(GALC)
PON: 
100458475(GALC)
MCC: 
693322(GALC)
MMU: 
14420(Galc)
RNO: 
314360(Galc)
CFA: 
403916(GALC)
AML: 
FCA: 
101084116(GALC)
BTA: 
533428(GALC)
SSC: 
100156917(GALC)
ECB: 
100034130(GALC)
MDO: 
100019504
SHR: 
100915302
OAA: 
100081052
GGA: 
423394(GALC)
MGP: 
100549468
TGU: 
100224899(GALC)
ACS: 
100564761
XTR: 
779723(galc)
DRE: 
406385(galcb) 449649(galca)
TRU: 
101074089
OLA: 
101163287
BFO: 
BRAFLDRAFT_59268 BRAFLDRAFT_83447
CIN: 
100182893(galc)
SPU: 
584869 584891
TAD: 
TRIADDRAFT_28351
AQU: 
100638294
MBR: 
MONBRDRAFT_480
BSA: 
Bacsa_1415
 » show all
Taxonomy
Reference
1  [PMID:5320641]
  Authors
Brady RO, Gal AE, Kanfer JN, Bradley RM.
  Title
The metabolism of glucocerebrosides. 3. Purification and properties of a glucosyl- and galactosylceramide-cleaving enzyme from rat intestinal tissue.
  Journal
J. Biol. Chem. 240 (1965) 3766-70.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9027-89-8
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