| Entry |
|
|---|
| Name |
sucrose alpha-glucosidase;
sucrose alpha-glucohydrolase;
sucrase;
sucrase-isomaltase;
sucrose.alpha.-glucohydrolase;
intestinal sucrase;
sucrase(invertase) |
|---|
| Class |
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl
compounds
 |
|---|
| Sysname |
sucrose-alpha-D-glucohydrolase |
|---|
| Reaction(IUBMB) |
Hydrolysis of sucrose and maltose by an alpha-D-glucosidase-type
action [RN:R00801 R06087] |
|---|
| Reaction(KEGG) |
R00801 R06087(G) > R00802 R06088(G)
 |
|---|
| Comment |
This enzyme is isolated from intestinal mucosa as a single
polypeptide chain that also displays activity towards isomaltose (EC
3.2.1.10 oligo-1,6-glucosidase). |
|---|
| Pathway |
PATH: ec00500 Starch and sucrose metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01203 sucrase-isomaltase / oligo-1,6-glucosidase |
|---|
| Genes |
HSA: 6476(SI)
PTR: 470988(SI)
MMU: 69983(Sis)
RNO: 497756(Si)
CFA: 488141(SI)
BTA: 504366(SI)
ECB: 100063242
MDO: 100013945
 |
|---|
| Structures |
PDB: 3CZE 3CZG 3CZK 3CZL |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:807575]
Conklin KA, Yamashiro KM, Gray GM.
Human intestinal sucrase-isomaltase. Identification of free sucrase
and isomaltase and cleavage of the hybrid into active distinct
subunits.
J. Biol. Chem. 250 (1975) 5735-41.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:291933]
Hauri HP, Quaroni A, Isselbacher KJ.
Biogenesis of intestinal plasma membrane: posttranslational route
and cleavage of sucrase-isomaltase.
Proc. Natl. Acad. Sci. U. S. A. 76 (1979) 5183-6.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:5073761]
Kolinska J, Kraml J.
Separation and characterization of sucrose-isomaltase and of
glucoamylase of rat intestine.
Biochim. Biophys. Acta. 284 (1972) 235-47.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:1182172]
Sigrist H, Ronner P, Semenza G.
A hydrophobic form of the small-intestinal sucrase-isomaltase
complex.
Biochim. Biophys. Acta. 406 (1975) 433-46.
Oryctolagus cuniculus |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:7002920]
Sjostrom H, Noren O, Christiansen L, Wacker H, Semenza G.
A fully active, two-active-site, single-chain sucrase.isomaltase
from pig small intestine. Implications for the biosynthesis of a
mammalian integral stalked membrane protein.
J. Biol. Chem. 255 (1980) 11332-8.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:5804876]
Takesue Y.
Purification and properties of rabbit intestinal sucrase.
J. Biochem. (Tokyo). 65 (1969) 545-52.
Oryctolagus cuniculus |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.2.1.48
IUBMB Enzyme Nomenclature: 3.2.1.48
ExPASy - ENZYME nomenclature database: 3.2.1.48
BRENDA, the Enzyme Database: 3.2.1.48
CAS: 37288-39-4 |
|---|
