KEGG   ENZYME: 3.2.1.48Help
Entry
EC 3.2.1.48                 Enzyme                                 

Name
sucrose alpha-glucosidase;
sucrose alpha-glucohydrolase;
sucrase;
sucrase-isomaltase;
sucrose.alpha.-glucohydrolase;
intestinal sucrase;
sucrase(invertase)
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
sucrose-alpha-D-glucohydrolase
Reaction(IUBMB)
Hydrolysis of sucrose and maltose by an alpha-D-glucosidase-type action [RN:R00801 R06087]
Reaction(KEGG)
Comment
This enzyme is isolated from intestinal mucosa as a single polypeptide chain that also displays activity towards isomaltose (EC 3.2.1.10 oligo-1,6-glucosidase).
History
EC 3.2.1.48 created 1972
Pathway
Starch and sucrose metabolism
Metabolic pathways
Orthology
K01203  
sucrase-isomaltase / oligo-1,6-glucosidase
Genes
HSA: 
6476(SI)
PTR: 
470988(SI)
PPS: 
GGO: 
PON: 
MCC: 
700840(SI)
MCF: 
MMU: 
69983(Sis)
RNO: 
497756(Si)
CGE: 
HGL: 
TUP: 
CFA: 
488141(SI)
AML: 
FCA: 
PTG: 
BTA: 
504366(SI)
BOM: 
PHD: 
CHX: 
SSC: 
CFR: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
TSP: 
 » show all
Taxonomy
Reference
1  [PMID:807575]
  Authors
Conklin KA, Yamashiro KM, Gray GM.
  Title
Human intestinal sucrase-isomaltase. Identification of free sucrase and isomaltase and cleavage of the hybrid into active distinct subunits.
  Journal
J. Biol. Chem. 250 (1975) 5735-41.
  Organism
Homo sapiens
Reference
2  [PMID:291933]
  Authors
Hauri HP, Quaroni A, Isselbacher KJ.
  Title
Biogenesis of intestinal plasma membrane: posttranslational route and cleavage of sucrase-isomaltase.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 76 (1979) 5183-6.
  Organism
Rattus norvegicus
Reference
3  [PMID:5073761]
  Authors
Kolinska J, Kraml J.
  Title
Separation and characterization of sucrose-isomaltase and of glucoamylase of rat intestine.
  Journal
Biochim. Biophys. Acta. 284 (1972) 235-47.
  Organism
Rattus norvegicus
Reference
4  [PMID:1182172]
  Authors
Sigrist H, Ronner P, Semenza G.
  Title
A hydrophobic form of the small-intestinal sucrase-isomaltase complex.
  Journal
Biochim. Biophys. Acta. 406 (1975) 433-46.
  Organism
Oryctolagus cuniculus
Reference
5  [PMID:7002920]
  Authors
Sjostrom H, Noren O, Christiansen L, Wacker H, Semenza G.
  Title
A fully active, two-active-site, single-chain sucrase.isomaltase from pig small intestine. Implications for the biosynthesis of a mammalian integral stalked membrane protein.
  Journal
J. Biol. Chem. 255 (1980) 11332-8.
  Organism
Sus scofa
Reference
6  [PMID:5804876]
  Authors
Takesue Y.
  Title
Purification and properties of rabbit intestinal sucrase.
  Journal
J. Biochem. (Tokyo). 65 (1969) 545-52.
  Organism
Oryctolagus cuniculus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37288-39-4

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