KEGG   ENZYME: 3.2.1.49Help
Entry
EC 3.2.1.49                 Enzyme                                 

Name
alpha-N-acetylgalactosaminidase;
alpha-acetylgalactosaminidase;
N-acetyl-alpha-D-galactosaminidase;
N-acetyl-alpha-galactosaminidase;
alpha-NAGAL;
alpha-NAGA;
alpha-GalNAcase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase
Reaction(IUBMB)
Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids
Reaction(KEGG)
(other) R04183 R05966(G)
Show
Comment
The human lysosomal enzyme is involved in the degradation of blood type A epitope.
History
EC 3.2.1.49 created 1972, modified 2011
Pathway
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
Orthology
K01204  alpha-N-acetylgalactosaminidase
Genes
HSA: 4668(NAGA)
PTR: 470279(NAGA)
PPS: 100991597(NAGA)
GGO: 101132690(NAGA)
PON: 100450338(NAGA)
NLE: 100605546(NAGA)
MCC: 713068(NAGA)
MCF: 102145379(NAGA)
CSAB: 103223407(NAGA)
RRO: 104670530(NAGA)
RBB: 108543578(NAGA)
CJC: 100397642(NAGA)
SBQ: 101052589(NAGA)
MMU: 17939(Naga)
RNO: 315165(Naga)
CGE: 100751670(Naga)
NGI: 103743459(Naga)
HGL: 101726122(Naga)
CCAN: 109689379(Naga)
OCU: 100350048(NAGA)
TUP: 102490461(NAGA)
CFA: 481226(NAGA)
AML: 100471467(NAGA)
UMR: 103674070(NAGA)
ORO: 101381151(NAGA)
FCA: 101083277(NAGA)
PTG: 102963636(NAGA)
AJU: 106979923(NAGA)
BTA: 533357(NAGA)
BOM: 102280167(NAGA)
BIU: 109559874(NAGA)
PHD: 102320395(NAGA)
CHX: 102170679(NAGA)
OAS: 100145858(NAGA)
SSC: 100142667(NAGA)
CFR: 102511662(NAGA)
CDK: 105091882(NAGA)
BACU: 103005673(NAGA)
LVE: 103072389(NAGA)
OOR: 101272207(NAGA)
ECB: 100070793(NAGA)
EPZ: 103541990(NAGA)
EAI: 106848492(NAGA)
MYB: 102258282(NAGA)
MYD: 102754122(NAGA)
HAI: 109371486(NAGA)
RSS: 109448832(NAGA)
PALE: 102887437(NAGA)
LAV: 100657188(NAGA)
MDO: 100018362(NAGA)
SHR: 100925898(NAGA)
OAA: 100086854(NAGA)
GGA: 396547(NAGA)
MGP: 100548783(NAGA)
CJO: 107313216(NAGA)
APLA: 101792497(NAGA)
ACYG: 106045224(NAGA)
TGU: 100229129(NAGA)
GFR: 102040040(NAGA)
FAB: 101821644(NAGA)
PHI: 102103812(NAGA)
PMAJ: 107204588(NAGA)
CCW: 104696358(NAGA)
FPG: 101922362(NAGA)
FCH: 102047533(NAGA)
CLV: 102085181
EGZ: 104134264(NAGA)
AAM: 106488675(NAGA)
ASN: 102387946(NAGA)
AMJ: 102561061(NAGA)
PSS: 102457826 102463470(NAGA)
CMY: 102938681 102948025(NAGA)
CPIC: 101940500 101949244(NAGA)
ACS: 100558544(naga) 100561397
PVT: 110076094(NAGA) 110087036
PBI: 103050555(NAGA) 103062412
GJA: 107109285 107124086(NAGA)
XLA: 443592(naga.S) 443753(naga.L)
XTR: 779501(naga)
NPR: 108791730(NAGA)
DRE: 560778(naga)
SRX: 107758144(naga)
SANH: 107669032(naga)
CCAR: 109044975(naga) 109044979
IPU: 108279976(naga)
TRU: 101073468(naga)
OLA: 101155483(naga)
XMA: 102234608(naga)
PRET: 103457699(naga)
NFU: 107378045(naga)
HCQ: 109523497(naga)
SASA: 100195244(nagab) 106605016(NAGAB)
ELS: 105017628(naga)
SFM: 108929235(naga)
CIN: 100182270
SPU: 587840
DSI: Dsimw501_GD22296(Dsim_GD22296)
MDE: 101901723
AAG: 5566514
AME: 725899
BIM: 100749267
BTER: 100650051
AEC: 105145873
ACEP: 105618932
PBAR: 105432733
HST: 105189481
CFO: 105249395
LHU: 105673165
PGC: 109855212
NVI: 100117222
NVL: 108564677
PMAC: 106720851
PRAP: 110997336
ZNE: 110833336
FCD: 110857972
CEL: CELE_R07B7.11(gana-1)
CBR: CBG23373(Cbr-gana-1)
TSP: Tsp_02909
OBI: 106872822
SHX: MS3_10001
HMG: 100204126
AQU: 100636085
DFA: DFA_08734
SMIN: v1.2.010510.t1(symbB.v1.2.010510.t1)
 » show all
Taxonomy
Reference
1  [PMID:9741689]
  Authors
Asfaw B, Schindler D, Ledvinova J, Cerny B, Smid F, Conzelmann E
  Title
Degradation of blood group A glycolipid A-6-2 by normal and mutant human skin fibroblasts.
  Journal
J. Lipid. Res. 39 (1998) 1768-80.
  Sequence
[hsa:4668]
Reference
2  [PMID:8954893]
  Authors
Zhu A, Monahan C, Wang ZK, Goldstein J
  Title
Expression, purification, and characterization of recombinant alpha-N-acetylgalactosaminidase produced in the yeast Pichia pastoris.
  Journal
Protein. Expr. Purif. 8 (1996) 456-62.
Reference
3  [PMID:19683538]
  Authors
Clark NE, Garman SC
  Title
The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases.
  Journal
J. Mol. Biol. 393 (2009) 435-47.
  Sequence
[hsa:4668]
Reference
4  [PMID:9065462]
  Authors
Hoskins LC, Boulding ET, Larson G
  Title
Purification and characterization of blood group A-degrading isoforms of alpha-N-acetylgalactosaminidase from Ruminococcus torques strain IX-70.
  Journal
J. Biol. Chem. 272 (1997) 7932-9.
Reference
5  [PMID:20139603]
  Authors
Harun-Or-Rashid M, Matsuzawa T, Satoh Y, Shiraishi T, Ando M, Sadik G, Uda Y
  Title
Purification and characterization of alpha-N-acetylgalactosaminidases I and II from the starfish Asterina amurensis.
  Journal
Biosci. Biotechnol. Biochem. 74 (2010) 256-61.
Reference
6  [PMID:18443780]
  Authors
Weignerova L, Filipi T, Manglova D, Kren V
  Title
Induction, purification and characterization of alpha-N-acetylgalactosaminidase from Aspergillus Niger.
  Journal
Appl. Microbiol. Biotechnol. 79 (2008) 769-74.
Reference
7  [PMID:11368317]
  Authors
Ashida H, Tamaki H, Fujimoto T, Yamamoto K, Kumagai H
  Title
Molecular cloning of cDNA encoding alpha-N-acetylgalactosaminidase from Acremonium sp. and its expression in yeast.
  Journal
Arch. Biochem. Biophys. 384 (2000) 305-10.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.49
IUBMB Enzyme Nomenclature: 3.2.1.49
ExPASy - ENZYME nomenclature database: 3.2.1.49
BRENDA, the Enzyme Database: 3.2.1.49
CAS: 9075-63-2

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