KEGG   ENZYME: 3.2.2.9Help
Entry
EC 3.2.2.9                  Enzyme                                 
Name adenosylhomocysteine nucleosidase;
S-adenosylhomocysteine hydrolase (ambiguous);
S-adenosylhomocysteine nucleosidase;
5'-methyladenosine nucleosidase;
S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase;
AdoHcy/MTA nucleosidase
Class Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
BRITE hierarchy
Sysname S-adenosyl-L-homocysteine homocysteinylribohydrolase
Reaction(IUBMB) S-adenosyl-L-homocysteine + H2O =
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine [RN:R00194]
Reaction(KEGG) R00194;
(other) R01401
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Substrate S-adenosyl-L-homocysteine [CPD:C00021];
H2O [CPD:C00001]
Product S-(5-deoxy-D-ribos-5-yl)-L-homocysteine [CPD:C03539];
adenine [CPD:C00147]
Comment Also acts on S-methyl-5'-thioadenosine to give adenine and
S-methyl-5-thioribose (cf. EC 3.2.2.16, methylthioadenosine
nucleosidase).
Pathway PATH: ec00270  Cysteine and methionine metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01243  S-adenosylhomocysteine/5'-methylthioadenosine
            nucleosidase
Genes POP: POPTR_814076
EHI: EHI_000720
EDI: EDI_026510
TET: TTHERM_00085560
GLA: GL50803_4059
TVA: TVAG_296300
PTI: PHATRDRAFT_14626
TPS: THAPSDRAFT_36459
ECO: b0159(mtn)
ECJ: JW0155(pfs)
ECD: ECDH10B_0139(pfs)
EBW: BWG_0152(mtn)
ECE: Z0170(pfs)
ECS: ECs0163
ECF: ECH74115_0169(mtnN)
ETW: ECSP_0160(pfs)
ECG: E2348C_0166(pfs)
ECC: c0195(pfs)
ECI: UTI89_C0175(mtn)
ECP: ECP_0169
ECV: APECO1_1826
ECW: EcE24377A_0164(mtnN)
ECX: EcHS_A0163(mtnN)
ECM: EcSMS35_0171(mtnN)
ECY: ECSE_0160
ECL: EcolC_3500
ECK: EC55989_0154(pfs)
ECQ: ECED1_0166(pfs)
ECR: ECIAI1_0158(pfs)
ECT: ECIAI39_0163(pfs)
ECZ: ECS88_0170(pfs)
EUM: ECUMN_0157(pfs)
ELF: LF82_1409(mtn)
EBL: B21_00157(pfs)
EBD: ECBD_3459
EBR: ECB_00158(pfs)
EOH: ECO103_0159(pfs)
EOI: ECO111_0161(pfs)
EOJ: ECO26_0162(pfs)
EFE: EFER_0182(pfs)
STY: STY0229(mtn)
STT: t0208(mtn)
SPT: SPA0213(mtn)
SEK: SSPA0206
SPQ: SPAB_00265
SEI: SPC_0223(mtn)
SEC: SC0207(pfs)
SEH: SeHA_C0244(mtnN)
SEE: SNSL254_A0228(mtnN)
SEW: SeSA_A0230(mtnN)
SEA: SeAg_B0246(mtnN)
SED: SeD_A0227(mtnN)
SEG: SG0211(pfs)
SET: SEN0212(pfs)
SES: SARI_02797
STM: STM0207(pfs)
YPE: YPO3384(mtn)
YPK: y0805(pfs)
YPM: YP_0301(mtn)
YPA: YPA_2883
YPN: YPN_0707
YPG: YpAngola_A0989(mtnN)
YPP: YPDSF_2974
YPS: YPTB0747(mtn)
YPI: YpsIP31758_3325(mtnN)
YPY: YPK_3454
YPB: YPTS_0780
YEN: YE0739(mtnN)
SFL: SF0151(pfs)
SFX: S0154(pfs)
SFV: SFV_0144(pfs)
SSN: SSON_0171(pfs)
SBO: SBO_0148(pfs)
SBC: SbBS512_E0151(mtnN)
SDY: SDY_0175(pfs)
ECA: ECA3303(mtn)
PCT: PC1_3098
PWA: Pecwa_1179
ETA: ETA_08820(mtn)
PLU: plu0906(mtnA)
PAY: PAU_00827(mtnA)
BUC: BU210(pfs)
BAS: BUsg204(pfs)
BAB: bbp192(pfs)
BAP: BUAP5A_207(pfs)
BAU: BUAPTUC7_209(pfs)
WBR: WGLp436(pfs)
SGL: SG0503
ENT: Ent638_0699
ESA: ESA_03181
CTU: Ctu_07900(mtnN)
KPN: KPN_00174(pfs)
KPE: KPK_4559(mtnN)
KPU: KP1_1012(mtnN)
CKO: CKO_03208
SPE: Spro_0787 Spro_1636
PMR: PMI0214(mtnN)
EIC: NT01EI_3101
ETR: ETAE_2773(mtnA)
HDE: HDEF_1490(mtn)
DDA: Dd703_2807
DDC: Dd586_3129
DZE: Dd1591_1040
HIN: HI1216(pfs)
HIT: NTHI1389(mtnA)
HIP: CGSHiEE_05950
HIQ: CGSHiGG_09810
HDU: HD1898(mtn)
HAP: HAPS_1552(mtn)
HSO: HS_1473(pfs)
HSM: HSM_0529
PMU: PM0194(pfs)
MSU: MS1537(pfs)
APL: APL_1637(mtn)
APJ: APJL_1670(mtn)
APA: APP7_1699
ASU: Asuc_1510
AAP: NT05HA_1177
AAT: D11S_1086
VCH: VC2379
VCO: VC0395_A1957(pfs)
VCM: VCM66_2302(pfs)
VCJ: VCD_001972
VVU: VV1_0558
VVY: VV0635
VPA: VP0479 VPA1089
VHA: VIBHAR_00923
VSP: VS_0468
VEX: VEA_004471
VFI: VF_1653 VF_2128(mtn)
VFM: VFMJ11_1779 VFMJ11_2236(mtnN)
VSA: VSAL_I1055 VSAL_I2565(mtnN) VSAL_II0383
PPR: PBPRA0538
PPU: PP_3254
PPF: Pput_2507
PPG: PputGB1_2641
PPW: PputW619_2657
CJA: CJA_3790
ACI: ACIAD0773
ACB: A1S_0024 A1S_0781
ABM: ABSDF0030 ABSDF2683
ABY: ABAYE3028 ABAYE3846
ABC: ACICU_00045 ACICU_00740
ABN: AB57_0064 AB57_0832(mtnN)
ABB: ABBFA_002830(mtnN) ABBFA_003487
SON: SO_1322(pfs) SO_3705
SDN: Sden_2801
SFR: Sfri_2966
SAZ: Sama_0855
SBL: Sbal_1176
SBM: Shew185_1220
SBN: Sbal195_1253
SBP: Sbal223_3137
SLO: Shew_1027
SPC: Sputcn32_1134
SSE: Ssed_1115
SPL: Spea_1001 Spea_1564 Spea_3850
SHE: Shewmr4_2874
SHM: Shewmr7_2956
SHN: Shewana3_3052
SHW: Sputw3181_3030
SHL: Shal_0417 Shal_1051 Shal_1632
SWD: Swoo_1217 Swoo_4916
SWP: swp_3830
CPS: CPS_4743
PHA: PSHAa0547(mtnN)
PAT: Patl_0518 Patl_0549
AMC: MADE_01241 MADE_01627 MADE_03423
PIN: Ping_0920
MCA: MCA0811
FTU: FTT_0397(mtn)
FTF: FTF0397(mtn)
FTW: FTW_1677(mtnN)
FTL: FTL_0463
FTH: FTH_0460
FTA: FTA_0491(mtnN)
FTM: FTM_0552(mtn)
FTN: FTN_0493(mtn)
FPH: Fphi_0356
TCX: Tcr_2130
NOC: Noc_1319
HNA: Hneap_0543
CSA: Csal_2050
MMW: Mmwyl1_4313
AHA: AHA_0953(mtnN-1) AHA_1706(mtnN-2)
ASA: ASA_2653(mtnN)
TAU: Tola_0615
DNO: DNO_0624(pfs)
BCI: BCI_0224(pfs)
NMA: NMA0978
NME: NMB0767(pfs)
NMC: NMC0720(pfs)
NMN: NMCC_0731(pfs)
NMI: NMO_0656(pfs)
NGO: NGO0345
NGK: NGK_0502
LHK: LHK_00108
RSO: RSc3374(pfs)
RPI: Rpic_3891
RPF: Rpic12D_4004
REU: Reut_A3041
REH: H16_A3337(pfs)
RME: Rmet_3198
CTI: RALTA_A2792(pfs)
BMA: BMA0929
BMV: BMASAVP1_A1462(mtnN)
BML: BMA10229_A0420(mtnN)
BMN: BMA10247_0743(mtnN)
BPS: BPSL1978
BPM: BURPS1710b_1848(mtnN)
BPL: BURPS1106A_1693(mtnN)
BPD: BURPS668_1671(mtnN)
BPR: GBP346_A1716(mtnN)
BTE: BTH_I2631
BVI: Bcep1808_1405
BUR: Bcep18194_A4587
BCN: Bcen_0961
BCH: Bcen2424_1443
BCM: Bcenmc03_1421
BCJ: BCAL1450
BAM: Bamb_1323
BAC: BamMC406_1364
BMU: Bmul_1872
BMJ: BMULJ_01369(pfs)
BXE: Bxe_A1338
BPH: Bphy_1589
BPY: Bphyt_2796
BGL: bglu_1g21880
PNU: Pnuc_0882
BPA: BPP0208
BBR: BB0212
BAV: BAV0173(mtn)
POL: Bpro_4542
PNA: Pnap_3796
AAV: Aave_4573
AJS: Ajs_3949
VEI: Veis_4426
DAC: Daci_0953
DIA: Dtpsy_3298
VAP: Vapar_0400 Vapar_2659
CTT: CtCNB1_4613
MPT: Mpe_A3574
HAR: HEAR3422(mtnN)
LCH: Lcho_0422
NET: Neut_1886
HPY: HP0089
HPJ: jhp0082
HPA: HPAG1_0090
HPS: HPSH_00440
HPG: HPG27_82
HPP: HPP12_0092
HPB: HELPY_0086
HHE: HH1283
HAC: Hac_1516
WSU: WS0528(PFS)
TDN: Suden_1392
CJE: Cj0117(pfs)
CJR: CJE0112(mtnA)
CJJ: CJJ81176_0152(mtnA)
CJU: C8J_0110(pfs)
CJD: JJD26997_0124(mtnA)
CFF: CFF8240_1515(mtnN)
CCV: CCV52592_1748(mtnN)
CHA: CHAB381_0698(mtnN)
CCO: CCC13826_0927(mtnN)
CLA: Cla_0205(pfs)
ABU: Abu_1585(pfs)
SDL: Sdel_0526
NIS: NIS_1209(pfs)
SUN: SUN_1755(pfs)
NAM: NAMH_0333(mtnN)
GSU: GSU0453(pfs) GSU1897
GME: Gmet_1274
GUR: Gura_2964
GLO: Glov_0361
GBM: Gbem_0877
GEO: Geob_2288
GEM: GM21_3383
PCA: Pcar_2078 Pcar_3117(pfs)
PPD: Ppro_0302
DSA: Desal_3751
BBA: Bd0846 Bd2653(pfs)
DPS: DP0328 DP0528 DP1546
PUB: SAR11_1212(pfs)
MLO: mlr6947
MES: Meso_0494
SME: SMc00395(pfs)
SMD: Smed_3518
ATU: Atu0282(pfs)
ATC: AGR_C_482
ARA: Arad_0511(pfs)
AVI: Avi_0328(pfs)
RET: RHE_CH00298(pfs)
REC: RHECIAT_CH0000335(pfs)
RLE: RL0316
RLT: Rleg2_4309
RLG: Rleg_4572
RHI: NGR_c36530
BME: BMEII0888
BMI: BMEA_B0359
BMF: BAB2_0843
BMB: BruAb2_0822
BMC: BAbS19_II07800
BMS: BRA0360
BMT: BSUIS_B0365
BOV: BOV_A0327
BCS: BCAN_B0363
BMR: BMI_II355
OAN: Oant_3057
NWI: Nwi_3067
NHA: Nham_3696
OCA: OCAR_7537
XAU: Xaut_0448
AZC: AZC_3701
CCR: CC_2266
CCS: CCNA_02349
PZU: PHZ_c0714
PDE: Pden_2777
NAR: Saro_3294
GBE: GbCGDNIH1_2407
RRU: Rru_A0061
RCE: RC1_0642(mtnN)
BSU: BSU27270(mtn)
BHA: BH1279 BH3238(pfs)
BAN: BA2564 BA2866 BA4602
BAR: GBAA2564 GBAA2866 GBAA4602
BAA: BA_3069 BA_3388 BA_5043
BAT: BAS2388 BAS2673 BAS4270
BAH: BAMEG_1732 BAMEG_2036 BAMEG_4639
BAI: BAA_2623 BAA_4622
BCE: BC2503 BC4368
BCA: BCE_2567 BCE_2638 BCE_2897 BCE_4456
BCZ: BCZK2305(pfs) BCZK2595 BCZK4118(mtnA)
BCR: BCAH187_A2620 BCAH187_A2915 BCAH187_A4507
BCB: BCB4264_A2529 BCB4264_A2883 BCB4264_A4493
BCU: BCAH820_2577 BCAH820_2872(mtnN) BCAH820_4454
BCG: BCG9842_B0743 BCG9842_B1905 BCG9842_B2362 BCG9842_B2792
BCQ: BCQ_2440(pfs) BCQ_2703(pfs) BCQ_4158(mtnA)
BCX: BCA_2649 BCA_2946 BCA_4486
BCY: Bcer98_1818 Bcer98_3086
BTK: BT9727_1702(pfs) BT9727_2344(pfs) BT9727_2625(pfs)
     BT9727_2626(pfs) BT9727_4107(mtnA)
BTL: BALH_2305 BALH_2571 BALH_2989(mtn) BALH_3959(mtnN)
BWE: BcerKBAB4_2376 BcerKBAB4_2671 BcerKBAB4_3050 BcerKBAB4_4221
BLI: BL02020(mtn)
BLD: BLi02855(mtn)
BCL: ABC1603(mthA)
BAY: RBAM_024370(mtn)
BPU: BPUM_2362(mtnN)
OIH: OB2000
GKA: GK2542
GTN: GTNG_2475
GWC: GWCH70_2476
GYM: GYMC10_1917
GYC: GYMC61_0977
AFL: Aflv_0759(mtn)
SAU: SA1427(pfs)
SAV: SAV1599(pfs)
SAW: SAHV_1586(pfs)
SAM: MW1550(pfs)
SAR: SAR1676(pfs)
SAS: SAS1536
SAC: SACOL1655(mtn)
SAB: SAB1471c
SAA: SAUSA300_1558(mtnN)
SAX: USA300HOU_1600(mtnN)
SAO: SAOUHSC_01702
SAJ: SaurJH9_1656
SAH: SaurJH1_1691
SAE: NWMN_1501(pfs)
SAD: SAAV_1590(mtn)
SEP: SE1285
SER: SERP1166(mtn)
SHA: SH1316(pfs)
SSP: SSP1159
SCA: Sca_1221(mtn)
LMO: lmo1494
LMF: LMOf2365_1513
LMH: LMHCC_1076(mtnN)
LMC: Lm4b_01504
LIN: lin1529
LWE: lwe1507(pfs)
LSP: Bsph_3858
ESI: Exig_1452 Exig_2065
EAT: EAT1b_2730
MCL: MCCL_1248
PJD: Pjdr2_3799
AAC: Aaci_2445
LLA: L132777(pfs)
LLK: LLKF_2073(pfs)
LLC: LACR_2076
LLM: llmg_2073(pfs)
SPY: SPy_0447(pfs)
SPZ: M5005_Spy_0365(pfs)
SPM: spyM18_0490(pfs)
SPG: SpyM3_0315(pfs)
SPS: SPs1542
SPH: MGAS10270_Spy0368(pfs)
SPI: MGAS10750_Spy0367(pfs)
SPJ: MGAS2096_Spy0384(pfs)
SPK: MGAS9429_Spy0368(pfs)
SPF: SpyM51500(mtn)
SPA: M6_Spy0389
SPB: M28_Spy0354(pfs)
SOZ: Spy49_0378(pfs)
SPN: SP_0991
SPD: SPD_0877(mtnN)
SPR: spr0894(pfs)
SPW: SPCG_0965(pfs)
SPX: SPG_0916
SNE: SPN23F_09160(mtnN)
SPV: SPH_1092(mtnN)
SNM: SP70585_1032(mtnN)
SJJ: SPJ_0932(mtnN)
SPP: SPP_0997(mtnN)
SNT: SPT_1213(mtnN)
SAG: SAG1535(pfs)
SAN: gbs1591
SAK: SAK_1558(pfs)
SMU: SMU.1632(pfs)
STC: str0566(pfs)
STL: stu0566(pfs)
STE: STER_0606
SSA: SSA_1639(pfs)
SSU: SSU05_1581
SSV: SSU98_1591
SSB: SSUBM407_1471(mtnN)
SSI: SSU1394(mtnN)
SSS: SSUSC84_1424(mtnN)
SGO: SGO_1466
SEQ: SZO_04800
SEZ: Sez_1471(mtnN)
SEU: SEQ_1662
SUB: SUB0471(mtnN)
SDS: SDEG_0486(mtnN)
LPL: lp_2181(mtn)
LPJ: JDM1_1826(mtn)
LJO: LJ0983
LJF: FI9785_1221(pfs)
LAC: LBA0820
LSA: LSA0776(pfs)
LSL: LSL_0859(pfs)
LDB: Ldb0752(pfs)
LBU: LBUL_0685
LBR: LVIS_1437
LCA: LSEI_1288
LCB: LCABL_15190(pfs)
LGA: LGAS_1192
LRE: Lreu_0602
LRF: LAR_0582
LHE: lhv_0866
LFE: LAF_0586
LRH: LGG_01299(pfs)
LRL: LC705_01317(pfs)
PPE: PEPE_1175
EFA: EF2694(pfs)
OOE: OEOE_1108
LME: LEUM_0706
LCI: LCK_01131
CAC: CAC2117(pfs)
CPE: CPE0056(mtn) CPE1050
CPF: CPF_0063(mtnN) CPF_1305(mtnN)
CPR: CPR_0066(mtnN)
CTC: CTC01619
CNO: NT01CX_1949
CDF: CD2611(mtnN)
CDC: CD196_2447(mtnN)
CDL: CDR20291_2494(mtnN)
CBO: CBO1471(mtn)
CBA: CLB_1496(mtnN)
CBH: CLC_1508(mtnN)
CBY: CLM_1708(mtnN)
CBL: CLK_0952(mtnN)
CBK: CLL_A3431(mtnN)
CBB: CLD_3079(mtnN)
CBI: CLJ_B1573(mtnN)
CBT: CLH_3183(mtnN)
CBF: CLI_1555(mtnN)
CBE: Cbei_4917
CKL: CKL_1197
CKR: CKR_1095
CPY: Cphy_3729
CCE: Ccel_1358
AMT: Amet_2799
AOE: Clos_1412
FMA: FMG_1222
EEL: EUBELI_00055
ERE: EUBREC_2601
MPU: MYPU_3360(pfs)
MPE: MYPE5210(pfs)
MGA: MGA_0051(pfs)
MMY: MSC_0443(pfs)
MMO: MMOB2770(pfs)
MHY: mhp473
MHJ: MHJ_0472(pfs)
MHP: MHP7448_0475(pfs)
MCP: MCAP_0528
MCO: MCJ_000870
MHO: MHO_0100
UUR: UU470(pfs)
UPA: UPA3_0489(mtnN)
UUE: UUR10_0527(mtnN)
ACL: ACL_1138(pfs)
MFL: Mfl372
MTU: Rv0091(mtn)
MTC: MT0100
MRA: MRA_0095(mtn)
MTF: TBFG_10092
MTB: TBMG_00092(TBMG_00092.1)
MBO: Mb0094(mtn)
MBB: BCG_0124(mtn)
MBT: JTY_0095(mtn)
MSM: MSMEG_1753(mtnN)
MUL: MUL_4862(mtn)
MMI: MMAR_0251(mtn)
CGL: NCgl2704(cgl2802)
CGB: cg3102
CEF: CE2636
CDI: DIP2131
CAR: cauri_2328
CKP: ckrop_1508
RER: RER_23450
ROP: ROP_64870
GBR: Gbro_3399
KRH: KRH_15970(mtn)
BFA: Bfae_06520
KSE: Ksed_04820
PAC: PPA1093
SRO: Sros_6409 Sros_7561
BLO: BL0318(pfs)
BLJ: BLD_1076(pfs)
BLN: Blon_0359
BAD: BAD_0275(pfs)
BLA: BLA_0324(mtnN)
BLC: Balac_0340
BLT: Balat_0340
CCU: Ccur_11070
SHI: Shel_17250
APV: Apar_0384
BBU: BB0375 BB0588 BBI06
BBZ: BbuZS7_0377 BbuZS7_0601(mtnN)
BGA: BG0374(pfs-1) BG0601(pfs-2)
BAF: BAPKO_0384(pfs-1) BAPKO_0619(pfs-2) BAPKO_3026
BTU: BT0375
BHR: BH0375
BDU: BDU_370(pfs-1)
BRE: BRE_374(pfs-1)
TPA: TP0170
TPP: TPASS_0170(pfs)
TDE: TDE0105
BHY: BHWA1_02624
ABA: Acid345_1742
ACA: ACP_0817
BTH: BT_4451
BFR: BF3598
BFS: BF3401
BVU: BVU_0894
PGI: PG0497(mtn)
PGN: PGN_1475
SRU: SRU_1556(mtnN)
CHU: CHU_2004(pfs)
DFE: Dfer_5287
FJO: Fjoh_3241
COC: Coch_2188
FSU: Fisuc_1888
FNU: FN1015
LBA: Lebu_2132
STR: Sterm_1894
SMF: Smon_0828
MIN: Minf_0400(pfs)
SYW: SYNW0169(pfs)
SYD: Syncc9605_0164
SYE: Syncc9902_0194
CYA: CYA_1636(mtnN)
CYB: CYB_1283(mtnN)
CYN: Cyan7425_1844
PMG: P9301_14421(pfs)
PMH: P9215_14761(pfs)
DRA: DR_1451
DGE: Dgeo_0776
DDR: Deide_12930
TTH: TTC1185
TTJ: TTHA1550
TMA: TM1129
TPT: Tpet_1616
TLE: Tlet_0708
TRQ: TRQ2_1682
TNA: CTN_1441
TNP: Tnap_1636
TME: Tmel_0485
TAF: THA_793
FNO: Fnod_0825
KOL: Kole_2130
TYE: THEYE_A0852
Taxonomy
Structures PDB: 1JYS  1NC1  1NC3  1Y6Q  1Y6R  1Z5N  1Z5O  1Z5P  3BL6  3DF9  
     3DP9  3EEI  
Reference
  Authors
  Title

  Journal
 1
Duerre, J.A.
A hydrolytic nucleosidase acting on S-adenosylhomocysteine and on
5-methylthioadenosine.
J. Biol. Chem. 237 (1962) 3737-3741.
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:782530]
Ferro AJ, Barrett A, Shapiro SK.
Kinetic properties and the effect of substrate analogues on
5'-methylthioadenosine nucleosidase from Escherichia coli.
Biochim. Biophys. Acta. 438 (1976) 487-94.
Escherichia coli [GN:eco]
Other DBs ExplorEnz - The Enzyme Database: 3.2.2.9
IUBMB Enzyme Nomenclature: 3.2.2.9
ExPASy - ENZYME nomenclature database: 3.2.2.9
BRENDA, the Enzyme Database: 3.2.2.9
CAS: 9055-10-1
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