KEGG   ENZYME: 3.3.2.1Help
Entry
EC 3.3.2.1                  Enzyme                                 
Name isochorismatase;
2,3-dihydro-2,3-dihydroxybenzoate synthase;
2,3-dihydroxy-2,3-dihydrobenzoate synthase;
2,3-dihydroxy-2,3-dihydrobenzoic synthase
Class Hydrolases;
Acting on ether bonds;
Ether hydrolases
BRITE hierarchy
Sysname isochorismate pyruvate-hydrolase
Reaction(IUBMB) isochorismate + H2O = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate
[RN:R03037]
Reaction(KEGG) R03037
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Substrate isochorismate [CPD:C00885];
H2O [CPD:C00001]
Product 2,3-dihydroxy-2,3-dihydrobenzoate;
pyruvate [CPD:C00022]
Pathway PATH: ec01053  Biosynthesis of siderophore group nonribosomal
               peptides
PATH: ec01061  Biosynthesis of phenylpropanoids
Orthology KO: K01252  enterobactin isochorismatase
KO: K04777  vibriobactin-specific isochorismatase
KO: K04779  isochorismatase
KO: K05993  isochorismatase
Genes AFM: AFUA_2G09355
ECO: b0595(entB)
ECJ: JW0587(entB)
ECD: ECDH10B_0555(entB)
EBW: BWG_0468(entB)
ECE: Z0737(entB)
ECS: ECs0634
ECF: ECH74115_0680(entB)
ETW: ECSP_0649(entB)
ECG: E2348C_0497(entB)
ECC: c0682(entB)
ECI: UTI89_C0597(entB)
ECP: ECP_0627
ECV: APECO1_1454(entB)
ECW: EcE24377A_0615(entB)
ECX: EcHS_A0646(entB)
ECM: EcSMS35_0615(entB)
ECY: ECSE_0662
ECL: EcolC_3049
ECK: EC55989_0587(entB)
ECQ: ECED1_0592(entB)
ECR: ECIAI1_0579(entB)
ECT: ECIAI39_0572(entB)
ECZ: ECS88_0634(entB)
EUM: ECUMN_0689(entB)
ELF: LF82_0564(entB)
EBL: B21_00551(entB)
EBD: ECBD_3059
EBR: ECB_00562(entB)
EOH: ECO103_0603(entB)
EOI: ECO111_0625(entB)
EOJ: ECO26_0670(entB)
EFE: EFER_2499(entB)
STY: STY0641(entB)
STT: t2271(entB)
SPT: SPA2137(entB)
SEK: SSPA1987
SPQ: SPAB_02966
SEI: SPC_0609(entB)
SEC: SC0628(entB)
SEH: SeHA_C0709(entB)
SEE: SNSL254_A0650(entB)
SEW: SeSA_A0755(entB)
SEA: SeAg_B0636(entB)
SED: SeD_A0693
SEG: SG0601(entB)
SET: SEN0566(entB)
SES: SARI_02339
STM: STM0597(entB)
YEN: YE3592
SFL: SF0509(entB)
SFX: S0515(entB)
SFV: SFV_0543(entB)
SSN: SSON_0546(entB)
SBO: SBO_0456(entB)
SBC: SbBS512_E0497(entB)
SDY: SDY_0526(entB)
ECA: ECA0479(entB) ECA1767
PCT: PC1_0464 PC1_2534
PWA: Pecwa_3737
PLU: plu2728(entB)
PAY: PAU_00894(phbB)
ENT: Ent638_0845 Ent638_1127
ESA: ESA_00798 ESA_02931
CTU: Ctu_30450(entB)
KPN: KPN_00318 KPN_00613(entB)
KPE: KPK_3346 KPK_3965(entB) KPK_4369
KPU: KP1_1177 KP1_1559(entB)
CKO: CKO_02566
SPE: Spro_1294 Spro_1403 Spro_3419
DDA: Dd703_1488 Dd703_2678 Dd703_3075
DDC: Dd586_2819
DZE: Dd1591_1230 Dd1591_1316
SML: Smlt2820
SMT: Smal_2274
VCH: VC0771
VCO: VC0395_A0300(vibB)
VCM: VCM66_0729(vibB)
VCJ: VCD_003555
VVU: VV2_0838
VVY: VVA1304
VHA: VIBHAR_01400
VFM: VFMJ11_A0729
PPR: PBPRB1822
PAP: PSPA7_0886
PAG: PLES_07141(phzD1)
PPF: Pput_1927
PSP: PSPPH_0909 PSPPH_1848
PFL: PFL_2630
PFO: Pfl01_3564
PFS: PFLU3491
PEN: PSEEN1524 PSEEN2254
AVN: Avin_21200(entB)
ACI: ACIAD2775(entB) ACIAD3473
ACB: A1S_2380 A1S_2580 A1S_3308
ABY: ABAYE0180 ABAYE1012 ABAYE1097(basF) ABAYE1888
ABC: ACICU_02577(basF)
ABN: AB57_2809
ABB: ABBFA_001063
SAZ: Sama_2135
SHE: Shewmr4_1153 Shewmr4_1847
SHM: Shewmr7_1224
SHN: Shewana3_1154
SDE: Sde_3398
TTU: TERTU_4061(dhbB)
HCH: HCH_06565
MMW: Mmwyl1_1623 Mmwyl1_1633
AHA: AHA_0970 AHA_2477
ASA: ASA_1840(entB) ASA_3330
CVI: CV_1483(entB) CV_4239
RME: Rmet_5659
BMA: BMAA0180 BMAA0508
BMV: BMASAVP1_0670 BMASAVP1_1353
BML: BMA10229_0966 BMA10229_1548
BMN: BMA10247_A0208 BMA10247_A1936 BMA10247_A1937
BPS: BPSL3069 BPSS2153
BPM: BURPS1710b_3597 BURPS1710b_A1005 BURPS1710b_A1265(entB)
BPL: BURPS1106A_3608 BURPS1106A_A2589
BPD: BURPS668_3583 BURPS668_3584 BURPS668_A2732 BURPS668_A3032
BPR: GBP346_A3757
BTE: BTH_I2926 BTH_II2229
BVI: Bcep1808_0496 Bcep1808_5101
BUR: Bcep18194_A3602 Bcep18194_B1272 Bcep18194_B1569
BCN: Bcen_2589 Bcen_3796 Bcen_3819
BCH: Bcen2424_0515 Bcen2424_4549 Bcen2424_4572
BCM: Bcenmc03_0487 Bcenmc03_5733
BCJ: BCAL0378 BCAM1751
BAM: Bamb_0419 Bamb_1688 Bamb_4001
BAC: BamMC406_4435 BamMC406_4464
BMU: Bmul_2883 Bmul_4071
BMJ: BMULJ_00352 BMULJ_04433
BXE: Bxe_A1712 Bxe_B2021
BPY: Bphyt_5812
BGL: bglu_2g02920 bglu_2g09250
PNA: Pnap_3001
AAV: Aave_1968
AJS: Ajs_0918
VEI: Veis_0839 Veis_1914
DAC: Daci_4231
VAP: Vapar_3421
DSA: Desal_2771
MXA: MXAN_3644
ARA: Arad_0554
RET: RHE_CH02341(ypch00763) RHE_PE00110(ype00048)
     RHE_PE00112(ype00050) RHE_PF00312(ypf00158)
REC: RHECIAT_CH0002439
RLE: pRL100352 pRL100355 pRL120673
RLT: Rleg2_1976
RLG: Rleg_2188
RHI: NGR_c24040
BME: BMEII0079
BMI: BMEA_B0016
BMF: BAB2_0013
BMB: BruAb2_0014(entB)
BMC: BAbS19_II00120
BMS: BRA0014(entB)
BOV: BOV_A0011(entB)
BCS: BCAN_B0016(phzD)
BMR: BMI_II14(entB)
BRA: BRADO2402 BRADO4247 BRADO5128 BRADO5505
BBT: BBta_2755 BBta_4623 BBta_5596 BBta_5987
RPC: RPC_4714
MEX: Mext_1695
BID: Bind_2950
JAN: Jann_3001
PDE: Pden_2383
ZMO: ZMO0758 ZMO1887
GOX: GOX2578
GDI: GDI_0348
GDJ: Gdia_2403
RRU: Rru_A0757 Rru_A1721
BSU: BSU31970(dhbB)
BAN: BA1382 BA1620 BA2371(dhbB) BA2963 BA4482
BAR: GBAA1382 GBAA1620 GBAA2371(dhbB) GBAA2963 GBAA4482
BAA: BA_1908 BA_2137 BA_2865 BA_3470 BA_4929
BAT: BAS1280 BAS1504 BAS2207 BAS2752 BAS4160
BAH: BAMEG_2971
BAI: BAA_1692
BCE: BC1365 BC1594 BC2305 BC2947 BC4255
BCA: BCE_1711 BCE_2401(dhbB) BCE_4338
BCZ: BCZK0283 BCZK1254 BCZK1466 BCZK2130(entB) BCZK2680 BCZK4009
BCR: BCAH187_A1761 BCAH187_A2471(bacB)
BCB: BCB4264_A1656 BCB4264_A2336(bacB)
BCU: BCAH820_1688 BCAH820_2389(bacB)
BCG: BCG9842_B2989(bacB) BCG9842_B3689
BCQ: BCQ_1652 BCQ_2297(entB)
BCX: BCA_1650 BCA_2438(bacB)
BCY: Bcer98_1757
BTK: BT9727_1252 BT9727_1476 BT9727_2146(entB) BT9727_2701
     BT9727_3999
BTL: BALH_0302 BALH_1224 BALH_1432 BALH_2110 BALH_2647
     BALH_2939(dhbB)
BWE: BcerKBAB4_1508 BcerKBAB4_2178
BLI: BL04023(dhbB)
BLD: BLi03899(dhbB)
BCL: ABC0969
BAY: RBAM_029020(dhbB)
OIH: OB0025 OB0279 OB0957(dhbB)
SAC: SACOL0172(entB)
SAA: SAUSA300_0189(entB)
LSP: Bsph_2493
ESI: Exig_0146
BBE: BBR47_50730
PJD: Pjdr2_2961
LLC: LACR_2347
LLM: llmg_1538 llmg_2333
SPI: MGAS10750_Spy0259
SPN: SP_1745
SPD: SPD_1555
SPR: spr1590
SPW: SPCG_1719
SPV: SPH_1854
SAG: SAG1660
SAN: gbs1704
SAK: SAK_1672
SSA: SSA_0580
SSV: SSU98_0364
SGO: SGO_0449
LSA: LSA0183 LSA1852
LCA: LSEI_2755
LRE: Lreu_1431
LME: LEUM_0367
CAC: CAC3465
CBO: CBO0945
CKL: CKL_2496(phzA)
MSM: MSMEG_4618
MVA: Mvan_1859 Mvan_3053 Mvan_4942
MJL: Mjls_3549
CKP: ckrop_1814(entB)
RHA: RHA1_ro02318
GBR: Gbro_0639
SCO: SCO0748(SCF81.07)
SGR: SGR_2598
ART: Arth_0076
RSA: RSal33209_0063 RSal33209_1730
TFU: Tfu_1870
FRE: Franean1_3619
FAL: FRAAL6302(dhbB) FRAAL6406
SEN: SACE_3852(dhbB) SACE_5166
SVI: Svir_20850
ABA: Acid345_1174 Acid345_2306
FJO: Fjoh_2530
GAU: GAU_3220 GAU_3263
HAU: Haur_3069
TTH: TTC1655
TTJ: TTHA0328
MMA: MM_1907
AFU: AF2151(entB)
HAL: VNG2537G(entB)
HMA: rrnAC2100(entB1)
HWA: HQ1060A(entB) HQ2280A(entB)
NPH: NP1170A(entB_2) NP1274A(entB_1)
TAC: Ta0454
TVO: TVN0771
PTO: PTO0118 PTO0621 PTO0671
RCI: RCIX277(entB)
APE: APE_2350.1
SMR: Smar_0504
IHO: Igni_1207
HBU: Hbut_0063
SSO: SSO2455(entB-like2)
STO: ST0582
SAI: Saci_0543
MSE: Msed_1527
PAI: PAE3001
PIS: Pisl_0413
PCL: Pcal_1098
PAS: Pars_1257
CMA: Cmaq_1336
TNE: Tneu_1717
TPE: Tpen_0105
Taxonomy
Structures PDB: 1NF8  1NF9  2FQ1  
Reference
  Authors
  Title


  Journal
  Organism
 1  [PMID:4306838]
Young IG, Gibson F.
Regulation of the enzymes involved in the biosynthesis of
2,3-dihydroxybenzoic acid in Aerobacter aerogenes and Escherichia
coli.
Biochim. Biophys. Acta. 177 (1969) 401-11.
Escherichia coli [GN:eco]
Other DBs ExplorEnz - The Enzyme Database: 3.3.2.1
IUBMB Enzyme Nomenclature: 3.3.2.1
ExPASy - ENZYME nomenclature database: 3.3.2.1
BRENDA, the Enzyme Database: 3.3.2.1
CAS: 37288-64-5
DBGET integrated database retrieval system