KEGG   ENZYME: 3.4.11.5Help
Entry
EC 3.4.11.5                 Enzyme                                 
Name prolyl aminopeptidase;
proline aminopeptidase;
Pro-X aminopeptidase;
cytosol aminopeptidase V;
proline iminopeptidase
Class Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
BRITE hierarchy
Reaction(IUBMB) Release of N-terminal proline from a peptide
Reaction(KEGG) (other) R00135
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Cofactor Manganese [CPD:C00034]
Comment A Mn2+-requiring enzyme present in the cytosol of mammalian and
microbial cells. In contrast to the mammalian form, the bacterial
form of the enzyme (type example of peptidase family S33) hydrolyses
both polyproline and prolyl-2-naphthylamide. The mammalian enzyme,
which is not specific for prolyl bonds, is possibly identical with
EC 3.4.11.1, leucyl aminopeptidase.
Pathway PATH: ec00330  Arginine and proline metabolism
Orthology KO: K01259  proline iminopeptidase
KO: K11142  cytosol aminopeptidase
Genes HSA: 51056(LAP3)
PTR: 461132(LAP3)
MCC: 715081(LAP3)
MMU: 66988(Lap3)
RNO: 289668(Lap3)
CFA: 479081(LAP3)
BTA: 781648(LAP3)
ECB: 100068668
MDO: 100014979
OAA: 100082274
GGA: 425306(LAP3)
TGU: 100226657
XLA: 414652
XTR: 496537(lap3)
DRE: 562854(lap3)
BFO: BRAFLDRAFT_278441
CIN: 100176888
DME: Dmel_CG32351
DPO: Dpse_GA19547
AGA: AgaP_AGAP001952 AgaP_AGAP003869
AAG: AaeL_AAEL000108 AaeL_AAEL000424
TCA: 663431
NVE: NEMVE_v1g247890
TAD: TRIADDRAFT_32578
ATH: AT2G14260(PIP) AT2G24200 AT4G30910
POP: POPTR_841939
OSA: 4339305(Os05g0513900)
PPP: PHYPADRAFT_188128
OLU: OSTLU_2836 OSTLU_93830
CME: CMS385C
PIC: PICST_48996(PAP2)
SPO: SPAC13A11.05
AFM: AFUA_2G05000
ANG: An11g04730(papA)
UMA: UM00432.1 UM03308.1
DDI: DDBDRAFT_0187236 DDB_0231024(lap)
TET: TTHERM_00049020 TTHERM_00433870 TTHERM_00760600
SPT: SPA1473
SEK: SSPA1369
SPQ: SPAB_01948
SEI: SPC_2349
SEC: SC1401(pip)
SEW: SeSA_A1477
SEG: SG1737(orf32)
SET: SEN1665(orf32)
STM: STM1380(orf32)
YPE: YPO1781(pip)
YPK: y2526
YPM: YP_1612(pip)
YPA: YPA_1156
YPN: YPN_2342
YPG: YpAngola_A1626(pip)
YPP: YPDSF_1342
YPS: YPTB1657(pip)
YPI: YpsIP31758_2344(pip)
YPY: YPK_2440
YPB: YPTS_1782
YEN: YE1793(pip)
PLU: plu2691(pip)
PAY: PAU_01844(pip)
SPE: Spro_1940
XFA: XF1510
XFT: PD0727(pip)
XFM: Xfasm12_0850
XFN: XfasM23_0763
XCC: XCC0836(pip) XCC2817
XCB: XC_1296 XC_3394
XCA: xccb100_1343(pip2) xccb100_3515(pip3)
XCV: XCV0945(pip) XCV3134(pip)
XAC: XAC0909(pip) XAC2987
XOO: XOO1269 XOO3642(pip)
XOM: XOO_1168 XOO_3441
XOP: PXO_02210 PXO_04582(pip)
SML: Smlt0843(pip)
SMT: Smal_0691
VFI: VF_A0792
PAE: PA5080
PAU: PA14_67110(pap)
PAP: PSPA7_5819(pip)
PAG: PLES_54701
PPU: PP_5028(pip)
PPF: Pput_4902
PPG: PputGB1_5078
PPW: PputW619_0437
PST: PSPTO_4540 PSPTO_5164(pip)
PSB: Psyr_0375 Psyr_4217
PSP: PSPPH_0357(pip) PSPPH_4239
PFL: PFL_0411(pip)
PFO: Pfl01_0371
PFS: PFLU0371(pip)
PEN: PSEEN5092(pip)
PMY: Pmen_0513
PSA: PST_0329(pip)
CJA: CJA_3656(pip)
SON: SO_4400
SAZ: Sama_2143 Sama_3403
SBL: Sbal_0316
SBM: Shew185_0315
SBN: Sbal195_0320
SBP: Sbal223_0321
SLO: Shew_3544
SSE: Ssed_0303
SPL: Spea_3908
SHE: Shewmr4_0317
SHM: Shewmr7_3707
SHN: Shewana3_0312
SHL: Shal_0361
SWD: Swoo_4617
SWP: swp_0281
CPS: CPS_0863(pip1) CPS_3964(pip2)
PAT: Patl_3951
SDE: Sde_0552
MAQ: Maqu_0771
AMC: MADE_03529
PIN: Ping_0253
TTU: TERTU_3200(pip)
LPN: lpg1843(pip)
LPF: lpl1808
LPP: lpp1807
LPC: LPC_1288(pip)
MCA: MCA1737(pip)
FTN: FTN_1731(pip)
FPH: Fphi_0876
TCX: Tcr_0168
NOC: Noc_0712
TGR: Tgr7_0208
HCH: HCH_01038(pip)
ABO: ABO_2257(pip)
AHA: AHA_2386 AHA_3475
NMA: NMA1122
NME: NMB0927(pip)
NMC: NMC0905(pip)
NMN: NMCC_0870(pip)
NGO: NGO0949
NGK: NGK_0849
RSO: RS04709(RSp0196)
RPI: Rpic_2487 Rpic_3807
RPF: Rpic12D_2093 Rpic12D_3920
REU: Reut_B3492
REH: H16_B1053(pap) H16_B2515(pip)
RME: Rmet_4027
CTI: RALTA_B0673 RALTA_B2241
BMA: BMAA1876(pip)
BMV: BMASAVP1_0886(pip)
BML: BMA10229_1173(pip)
BMN: BMA10247_A2151(pip)
BPS: BPSS0201(pip)
BPM: BURPS1710b_A1728
BPL: BURPS1106A_A0279(pip)
BPD: BURPS668_A0373(pip)
BTE: BTH_II2193
BVI: Bcep1808_4676 Bcep1808_6559
BUR: Bcep18194_A4280 Bcep18194_B1183 Bcep18194_B1929 Bcep18194_B2393
     Bcep18194_B2445
BCN: Bcen_3244 Bcen_4251
BCH: Bcen2424_4115 Bcen2424_5124
BCM: Bcenmc03_3408 Bcenmc03_5157
BCJ: BCAM1240(pip) BCAM2366(pip)
BAM: Bamb_3526 Bamb_6163
BAC: BamMC406_4009 BamMC406_5896
BMU: Bmul_4474 Bmul_5970
BMJ: BMULJ_04036(pip) BMULJ_05556(pip)
BXE: Bxe_B2466
BPE: BP3691
BPA: BPP0504
BBR: BB0509
BPT: Bpet4322
BAV: BAV0454(pip)
RFR: Rfer_0089
POL: Bpro_1603
PNA: Pnap_1088
MPT: Mpe_A2584
HAR: HEAR1383 HEAR3357
MMS: mma_3579(pip)
NEU: NE2295
NET: Neut_2133
AZO: azo1185(pip)
DAR: Daro_1031 Daro_1698
TBD: Tbd_0887
MFA: Mfla_2315
BBA: Bd3480(pip)
MXA: MXAN_6006(pip)
SCL: sce5272
MLO: mlr7803
PLA: Plav_0503
SME: SMc02547(pip1)
SMD: Smed_0717
ATU: Atu1069(pip)
ATC: AGR_C_1974
ARA: Arad_1632(pip) Arad_8441(pipb2) Arad_8444(pipb1)
RET: RHE_CH01420(pipch1) RHE_CH02208(pipch2) RHE_PB00088(pipb1)
     RHE_PB00090(pipb2)
REC: RHECIAT_CH0001490(pipch1) RHECIAT_CH0002297(pipch2)
     RHECIAT_PC0000236(pipc1) RHECIAT_PC0000238(pipc2)
RLE: RL1539(pip) RL2538(pip) pRL100270 pRL90179(pepI) pRL90181(pip)
RLT: Rleg2_1033 Rleg2_1856 Rleg2_6375 Rleg2_6377
RLG: Rleg_1180
RHI: NGR_c08660
BME: BMEI1608
BMF: BAB1_0344(pip)
BMB: BruAb1_0340(pip)
BMC: BAbS19_I03140
BMS: BR0314(pip)
BMT: BSUIS_A0343(pip)
BOV: BOV_0330(pip)
BCS: BCAN_A0323(pip)
BMR: BMI_I320(pip)
OAN: Oant_0407
BJA: bll4403(pip) blr6740(pip)
BRA: BRADO4325 BRADO5798(pip) BRADO6453
BBT: BBta_1192 BBta_5020 BBta_5500 BBta_6305(pip)
RPA: RPA3630
RPB: RPB_1894
RPC: RPC_3668
RPD: RPD_3473
RPE: RPE_3706
RPT: Rpal_4151
CCR: CC_1227
CCS: CCNA_01285
CAK: Caul_1598
SIL: SPO0066(pip)
SIT: TM1040_2907
RSP: RSP_1174(pip)
RSH: Rsph17029_2836
RSQ: Rsph17025_2767
RSK: RSKD131_2571
JAN: Jann_0299
RDE: RD1_0391(pip)
PDE: Pden_2590
DSH: Dshi_3551(pip)
MMR: Mmar10_1122 Mmar10_2011
HNE: HNE_2930(pip)
SAL: Sala_2006
SWI: Swit_0937 Swit_4410
ELI: ELI_06495
GBE: GbCGDNIH1_0167
ACR: Acry_1042
GDI: GDI_2355(pip) GDI_3112
GDJ: Gdia_0601 Gdia_3255
RRU: Rru_A0084 Rru_A2180
RCE: RC1_2236(pip)
MAG: amb0597
BAN: BA2217
BAR: GBAA2217
BAA: BA_2719
BAT: BAS2061
BAH: BAMEG_2379
BCE: BC2171 BC2337 BC4663
BCA: BCE_1173 BCE_1959 BCE_2247 BCE_4805
BCZ: BCZK1692 BCZK2000(pip) BCZK3858 BCZK4415
BCR: BCAH187_A2329 BCAH187_A4801
BCB: BCB4264_A2199 BCB4264_A2370 BCB4264_A4779
BCU: BCAH820_2245 BCAH820_4784
BCG: BCG9842_B0460 BCG9842_B2962 BCG9842_B3126
BCQ: BCQ_2155(pip) BCQ_4482
BCX: BCA_1946 BCA_2301 BCA_4784
BTK: BT9727_2001(pip) BT9727_4398
BTL: BALH_0955(pip) BALH_1656(pip) BALH_1978(pip) BALH_4246
BWE: BcerKBAB4_2042 BcerKBAB4_4497
BCL: ABC1243 ABC1974
OIH: OB1045
SAA: SAUSA300_0601 SAUSA300_0604
LPL: lp_0088(pepI) lp_0853(pepR1) lp_2919(pepR2)
LJO: LJ0054
LAC: LBA0092 LBA1658 LBA1957(pepL)
LSA: LSA0133(pepR)
LDB: Ldb1896(pepIP) Ldb1909(pepPN)
LBU: LBUL_1762 LBUL_1775
LBR: LVIS_1783 LVIS_2232
LCA: LSEI_0750 LSEI_1988
LCB: LCABL_08170(pepR1) LCABL_21620(pepR)
LGA: LGAS_0052 LGAS_1849
LRE: Lreu_1648
LRF: LAR_1539
LHE: lhv_1759
PPE: PEPE_0379
OOE: OEOE_0576
CDF: CD3041(pepI)
CBO: CBO2031(pepIP)
CBA: CLB_1972(pepIP)
CBH: CLC_1977(pepIP)
CBY: CLM_2246(pepIP)
CBL: CLK_1485(pepIP)
CBB: CLD_2595(pepIP)
CBI: CLJ_B2247
CBF: CLI_2096(pepIP)
MGE: MG_020(pip)
MPE: MYPE8330(pip)
MAA: MAG_0710(pip)
MTU: Rv0840c(pip)
MTC: MT0862(pip)
MRA: MRA_0848(pip)
MTF: TBFG_10858
MTB: TBMG_03150(TBMG_03150.1)
MBO: Mb0863c(pip)
MBB: BCG_0892c(pip)
MBT: JTY_0862(pip)
MPA: MAP0684c
MAV: MAV_0868
MSM: MSMEG_2681
MUL: MUL_0358(pip)
MGI: Mflv_5441
MMI: MMAR_4789(pip)
CGB: cg0684(papA)
NFA: nfa16480
RHA: RHA1_ro01171 RHA1_ro03520
RER: RER_36530(pip)
ROP: ROP_08970(pip)
SCO: SCO1989(SC7H2.03c)
SMA: SAV_875(pip)
SGR: SGR_3154
LXX: Lxx21800(pip)
CMI: CMM_0804(pipA) CMM_0817(pipB)
CMS: CMS_0076
AAU: AAur_2073(pip)
RSA: RSal33209_0096 RSal33209_1811
PAC: PPA0932 PPA2174
TFU: Tfu_2349
FRA: Francci3_2191
FAL: FRAAL0535(pip)
KRA: Krad_0552
SEN: SACE_2704(pip)
STP: Strop_2620 Strop_2777
SAQ: Sare_4387
BAD: BAD_0607(pap)
TDE: TDE2776(pip)
SUS: Acid_6970
GFO: GFO_0839(pip) GFO_0853(pip)
FJO: Fjoh_1984
FNU: FN0752
SYP: SYNPCC7002_A0899(pip)
CYA: CYA_2804(pip)
CYB: CYB_0956(pip)
CYN: Cyan7425_1122
GVI: gll1435
ANA: alr1270
NPU: Npun_F5930
AVA: Ava_2994 Ava_3602 Ava_4415
PMM: PMM0356
PMN: PMN2A_0523
PMI: PMT9312_0360
PMB: A9601_03911
PMC: P9515_03961
PMG: P9301_03901
PMH: P9215_03931
PME: NATL1_12631
TER: Tery_3860
DGE: Dgeo_0193
TTH: TTC1457
TTJ: TTHA1809
TAC: Ta0830
TVO: TVN0910
SSO: SSO3115
SAI: Saci_1940(pip) Saci_1942
SIS: LS215_2414
SIA: M1425_2247
SIM: M1627_2326
SIN: YN1551_0528
Taxonomy
Structures PDB: 1AZW  1MT3  1MTZ  1MU0  1QTR  1WM1  1X2B  1X2E  1XQV  1XQW  
     1XQX  1XQY  1XRL  1XRM  1XRN  1XRO  1XRP  1XRQ  1XRR  2J9A  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:14497218]
SARID S, BERGER A, KATCHALSKI E.
Proline iminopeptidase. II. Purification and comparison with
iminodipeptidase (prolinase).
J. Biol. Chem. 237 (1962) 2207-12.
Escherichia coli [GN:eco]
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:4803482]
Nordwig A, Mayer H.
The cleavage of prolyl peptides by kidney peptidases. Detection of a
new peptidase capable of removing N-terminal proline.
Hoppe. Seylers. Z. Physiol. Chem. 354 (1973) 380-3.
Sus scofa [GN:ssc]
Reference
  Authors
  Title

  Journal
  Organism
 3  [PMID:2373079]
Turzynski A, Mentlein R.
Prolyl aminopeptidase from rat brain and kidney. Action on peptides
and identification as leucyl aminopeptidase.
Eur. J. Biochem. 190 (1990) 509-15.
Rattus norvegicus [GN:rno]
Other DBs ExplorEnz - The Enzyme Database: 3.4.11.5
IUBMB Enzyme Nomenclature: 3.4.11.5
ExPASy - ENZYME nomenclature database: 3.4.11.5
BRENDA, the Enzyme Database: 3.4.11.5
CAS: 9025-40-5
DBGET integrated database retrieval system