| Entry |
|
|---|
| Name |
beta-Ala-His dipeptidase;
serum carnosinase |
|---|
| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidases
 |
|---|
| Reaction(IUBMB) |
Preferential hydrolysis of the beta-Ala!His dipeptide (carnosine),
and also anserine, Xaa!His dipeptides and other dipeptides including
homocarnosine [RN:R01166 R03288] |
|---|
| Reaction(KEGG) |
R01166 R03288
 |
|---|
| Cofactor |
Citrate [CPD:C00158];
Cadmium [CPD:C01413] |
|---|
| Comment |
Present in the serum of humans and higher primates, but not in the
serum of other mammals. Activated by Cd2+ and citrate. Belongs in
peptidase family M20. |
|---|
| Pathway |
PATH: ec00340 Histidine metabolism
PATH: ec00410 beta-Alanine metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K05604 beta-Ala-His dipeptidase |
|---|
| Genes |
HSA: 84735(CNDP1)
PTR: 455474(CNDP1)
MCC: 695195(CNDP1)
MMU: 338403(Cndp1)
RNO: 307212(Cndp1)
CFA: 476165(CNDP1)
BTA: 614200(CNDP1)
ECB: 100061728(CNDP1)
OAA: 100076860
GGA: 421012(CNDP1)
XLA: 398917
 |
|---|
| Structures |
PDB: 3DLJ |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:7116644]
Lenney JF, George RP, Weiss AM, Kucera CM, Chan PW, Rinzler GS.
Human serum carnosinase: characterization, distinction from cellular
carnosinase, and activation by cadmium.
Clin. Chim. Acta. 123 (1982) 221-31.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:1903095]
Jackson MC, Kucera CM, Lenney JF.
Purification and properties of human serum carnosinase.
Clin. Chim. Acta. 196 (1991) 193-205.
Homo sapiens [GN:hsa] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.4.13.20
IUBMB Enzyme Nomenclature: 3.4.13.20
ExPASy - ENZYME nomenclature database: 3.4.13.20
BRENDA, the Enzyme Database: 3.4.13.20
CAS: 525589-43-9 |
|---|
