KEGG   ENZYME: 3.4.13.3Help
Entry
EC 3.4.13.3                 Enzyme                                 
Name Xaa-His dipeptidase;
aminoacylhistidine dipeptidase;
carnosinase;
homocarnosinase;
dipeptidase M;
X-His dipeptidase
Class Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidases
BRITE hierarchy
Reaction(IUBMB) Hydrolysis of Xaa!His dipeptides
Reaction(KEGG) (other) R00899 R01166 R01992 R04951
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Cofactor Manganese [CPD:C00034];
Zinc [CPD:C00038]
Inhibitor EDTA [CPD:C00284]
Effector Thiol [CPD:C00145]
Comment A mammalian cytosolic enzyme that also acts on anserine and
homocarnosine (but not on homoanserine), and to a lesser extent on
some other aminoacyl-L-histidine dipeptides. Activated by thiols;
inhibited by metal-chelating agents. This enzyme in peptidase family
M25 may be identical with EC 3.4.13.18, cytosol nonspecific
dipeptidase.
Pathway PATH: ec00330  Arginine and proline metabolism
PATH: ec00340  Histidine metabolism
PATH: ec00410  beta-Alanine metabolism
PATH: ec00480  Glutathione metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01270  aminoacylhistidine dipeptidase
Genes EHI: EHI_127280
EDI: EDI_190630
GLA: GL50803_8407
TVA: TVAG_056190 TVAG_090090 TVAG_385820
ECO: b0237(pepD)
ECJ: JW0227(pepD)
ECD: ECDH10B_0219(pepD)
EBW: BWG_0219(pepD)
ECE: Z0298(pepD)
ECS: ECs0264
ECF: ECH74115_0282(pepD)
ETW: ECSP_0271(pepD)
ECG: E2348C_0230(pepD)
ECC: c0383(pepD)
ECI: UTI89_C0277(pepD)
ECP: ECP_0266
ECV: APECO1_1732(pepD)
ECW: EcE24377A_0269(pepD)
ECX: EcHS_A0264(pepD)
ECM: EcSMS35_0291(pepD)
ECY: ECSE_0257
ECL: EcolC_3344
ECK: EC55989_0261(pepD)
ECQ: ECED1_0271(pepD)
ECR: ECIAI1_0276(pepD)
ECT: ECIAI39_0414(pepD)
ECZ: ECS88_0272(pepD)
EUM: ECUMN_0303(pepD)
ELF: LF82_1613(pepD)
EBL: B21_00235(pepD)
EBD: ECBD_3384
EBR: ECB_00232(pepD)
EOH: ECO103_0252(pepD)
EOI: ECO111_0299(pepD)
EOJ: ECO26_0293(pepD)
EFE: EFER_2741(pepD)
STY: STY0361(pepD)
STT: t2534(pepD)
SPT: SPA2439(pepD)
SEK: SSPA2277
SPQ: SPAB_03286
SEI: SPC_0327(pepD)
SEC: SC0317(pepD)
SEH: SeHA_C0357(pepD)
SEE: SNSL254_A0355(pepD)
SEW: SeSA_A0365(pepD)
SEA: SeAg_B0350(pepD)
SED: SeD_A0346(pepD)
SEG: SG0327(pepD)
SET: SEN0299(pepD)
SES: SARI_02696
STM: STM0316(pepD)
YPE: YPO3230(pepD)
YPK: y0960(pepD)
YPM: YP_0703(pepD1)
YPA: YPA_2720
YPN: YPN_0865
YPG: YpAngola_A3307(pepD)
YPP: YPDSF_2857
YPS: YPTB0897(pepD)
YPI: YpsIP31758_3156(pepD)
YPY: YPK_3295
YPB: YPTS_0939
YEN: YE3206(pepD)
SFL: SF0285(pepD)
SFX: S0306(pepD)
SFV: SFV_0293(pepD)
SSN: SSON_0279(pepD)
SBO: SBO_0243(pepD)
SBC: SbBS512_E0234(pepD)
SDY: SDY_0480(pepD)
ECA: ECA3467(pepD)
PCT: PC1_3290
PWA: Pecwa_3437
ETA: ETA_25990(pepD)
PLU: plu1240(pepD)
PAY: PAU_03221
SGL: SG0597
ENT: Ent638_0763
ESA: ESA_03116
CTU: Ctu_08490(pepD)
KPN: KPN_00249(pepD)
KPE: KPK_4483(pepD)
KPU: KP1_1095(pepD)
CKO: CKO_02959
SPE: Spro_0963
PMR: PMI0364(pepD)
EIC: NT01EI_0911
ETR: ETAE_0792(pepD)
DDA: Dd703_0928
DZE: Dd1591_0895
HIN: HI0675(pepD)
HIT: NTHI0797(pepD)
HIP: CGSHiEE_08720(xerC)
HIQ: CGSHiGG_06655
HDU: HD1832(pepD)
HAP: HAPS_1465(pepD)
HSO: HS_0004(pepD)
HSM: HSM_1895
PMU: PM1368(pepD)
MSU: MS2118(pepD)
APL: APL_0254(pepD)
APJ: APJL_0262(pepD)
APA: APP7_0256
ASU: Asuc_0178
AAP: NT05HA_2022
AAT: D11S_0733
VCH: VC2279
VCO: VC0395_A1869(pepD)
VCM: VCM66_2202(pepD)
VCJ: VCD_002062
VVU: VV1_0333
VVY: VV0852
VPA: VP0671
VHA: VIBHAR_01157
VSP: VS_2422
VEX: VEA_004273
VFI: VF_0736(pepD)
VFM: VFMJ11_0755
VSA: VSAL_I0973
PPR: PBPRA0833
PRW: PsycPRwf_1035
ACI: ACIAD2220(pepD)
ACB: A1S_2274
ABM: ABSDF1254(pepD)
ABY: ABAYE1209(pepD)
ABC: ACICU_02472
ABN: AB57_2628
ABB: ABBFA_001170
SON: SO_1115(pepD)
SDN: Sden_1011
SFR: Sfri_0962
SAZ: Sama_1565 Sama_2519
SBL: Sbal_0940 Sbal_2623 Sbal_2626
SBM: Shew185_2660 Shew185_3422
SBN: Sbal195_2738 Sbal195_3547
SBP: Sbal223_1725 Sbal223_3350
SLO: Shew_2160 Shew_2852
SPC: Sputcn32_0954
SSE: Ssed_2691 Ssed_3421
SPL: Spea_3091
SHE: Shewmr4_0948 Shewmr4_2301
SHM: Shewmr7_0986 Shewmr7_2371
SHN: Shewana3_0950 Shewana3_2491
SHW: Sputw3181_3222
SHL: Shal_2429 Shal_3175
SWD: Swoo_1928 Swoo_3603
SWP: swp_1180 swp_2283
CPS: CPS_0180(pepD) CPS_1363
PHA: PSHAa2204
PIN: Ping_0894
HCH: HCH_00218(pepD)
CSA: Csal_2957
MMW: Mmwyl1_2361
AHA: AHA_3426(pepD)
ASA: ASA_0887(pepD)
TAU: Tola_0805
DNO: DNO_0013 DNO_0049
CVI: CV_2694(pepD)
LHK: LHK_01745(pepD)
AZO: azo1259(pepD)
DAR: Daro_1720
HHE: HH0668
WSU: WS1509
CJE: Cj0980
CJR: CJE1062(pepD)
CJJ: CJJ81176_0999(pepD)
CJU: C8J_0919(pepD)
CJD: JJD26997_0809(pepD)
CFF: CFF8240_1073
CCV: CCV52592_0116
CHA: CHAB381_0810
CCO: CCC13826_2041
CLA: Cla_0562(pepD)
ABU: Abu_1305(pepD)
NIS: NIS_0557(pepD)
SUN: SUN_1808(pepD)
NAM: NAMH_0507
GBM: Gbem_3389
ADE: Adeh_2079
ACP: A2cp1_1877
AFW: Anae109_1744
ANK: AnaeK_1798
RHI: NGR_c06240(pepD)
BAN: BA2498(pepD)
BAR: GBAA2498(pepD)
BAA: BA_2989
BAT: BAS2319
BAH: BAMEG_2105(pepD)
BAI: BAA_2553(pepD)
BCE: BC2439
BCA: BCE_2527(pepD)
BCZ: BCZK2240(pepD)
BCR: BCAH187_A2587(pepD)
BCB: BCB4264_A2447(pepD)
BCU: BCAH820_2514(pepD)
BCG: BCG9842_B2888(pepD)
BCQ: BCQ_2410(pepD)
BCX: BCA_2580(pepD)
BCY: Bcer98_1800
BTK: BT9727_2284(pepD)
BTL: BALH_2243
BWE: BcerKBAB4_2301
SPZ: M5005_Spy_0793 M5005_Spy_1271
SPH: MGAS10270_Spy0906 MGAS10270_Spy1286
SPI: MGAS10750_Spy0941 MGAS10750_Spy1378
SPJ: MGAS2096_Spy0864 MGAS2096_Spy1290
SPK: MGAS9429_Spy0907 MGAS9429_Spy1265
SPF: SpyM50976(pepV)
SPA: M6_Spy0810 M6_Spy1292
SPB: M28_Spy0767 M28_Spy1209
LSA: LSA0424(pepV)
LSL: LSL_0447
LDB: Ldb1746(pepV)
LBR: LVIS_2032
LCA: LSEI_0813
LGA: LGAS_0439
LRE: Lreu_1291
LME: LEUM_1971
CPE: CPE2148(pepD) CPE2251(pepD)
CPF: CPF_2403(pepD) CPF_2512(pepD)
CPR: CPR_2115(pepD) CPR_2216(pepD)
CTC: CTC02317
CNO: NT01CX_0660
CTH: Cthe_3149
CDF: CD0708(pepD)
CBO: CBO2232 CBO2867(pepD)
CBA: CLB_2172(pepD-2) CLB_2833(pepD-3)
CBH: CLC_2155(pepD-2) CLC_2766(pepD-3)
CBY: CLM_2438(pepD) CLM_3264(pepD)
CBL: CLK_1672(pepD) CLK_2264(pepD)
CBK: CLL_A0558
CBB: CLD_1675(pepD) CLD_2343(pepD)
CBI: CLJ_B2443(pepD_2) CLJ_B3122(pepD_3)
CBT: CLH_0543
CBF: CLI_2281(pepD-2) CLI_2923(pepD-3)
CBE: Cbei_0486
CKL: CKL_0692
CKR: CKR_0614
CPY: Cphy_2796
AOE: Clos_0567
FMA: FMG_0213 FMG_1462
EEL: EUBELI_00203 EUBELI_01205 EUBELI_20050
ERE: EUBREC_0889
BBU: BB0608
BBZ: BbuZS7_0622
BGA: BG0621(pepD)
BAF: BAPKO_0641(pepD)
BTU: BT0608
BHR: BH0608
BDU: BDU_608(pepD)
BRE: BRE_611(pepD)
TDE: TDE2228
ABA: Acid345_1504
BTH: BT_1615 BT_4045
BFR: BF0780 BF3239
BFS: BF0708 BF3079(pepD)
BVU: BVU_1927 BVU_2372
PGI: PG0137(pepD-1) PG0537(pepD-2)
PGN: PGN_0250 PGN_1434
PDI: BDI_2092 BDI_2582
GFO: GFO_0785(pepD)
FJO: Fjoh_2400
FPS: FP1929(pepD)
FBA: FIC_01558
COC: Coch_2053
FNU: FN1277 FN1408 FN1804
CTE: CT1058(pepD)
CPC: Cpar_1013
CPH: Cpha266_1680
CPB: Cphamn1_1387
CLI: Clim_1142
PLT: Plut_0525
PPH: Ppha_1584
PAA: Paes_1222
MAC: MA2653
MBA: Mbar_A3039
MMA: MM_2749
Taxonomy
Structures PDB: 1LFW  2QYV  
Reference
  Authors
  Title
  Journal
 1
Hanson, H.T. and Smith, E.L.
Carnosinase: an enzyme of swine kidney.
J. Biol. Chem. 179 (1949) 789-801.
Reference
  Authors
  Title
  Journal
 2  [PMID:13743376]
ROSENBERG A.
The activation of carnosinase by divalent metal ions.
Biochim. Biophys. Acta. 45 (1960) 297-316.
Reference
  Authors
  Title

  Journal
  Organism
 3  [PMID:21630]
Lenney JF, Kan SC, Siu K, Sugiyama GH.
Homocarnosinase: a hog kidney dipeptidase with a broader specificity
than carnosinase.
Arch. Biochem. Biophys. 184 (1977) 257-66.
Sus scofa [GN:ssc]
Reference
  Authors
  Title


  Journal
  Organism
 4  [PMID:2378680]
Lenney JF.
Separation and characterization of two carnosine-splitting cytosolic
dipeptidases from hog kidney (carnosinase and non-specific
dipeptidase).
Biol. Chem. Hoppe. Seyler. 371 (1990) 433-40.
Sus scofa [GN:ssc]
Other DBs ExplorEnz - The Enzyme Database: 3.4.13.3
IUBMB Enzyme Nomenclature: 3.4.13.3
ExPASy - ENZYME nomenclature database: 3.4.13.3
BRENDA, the Enzyme Database: 3.4.13.3
CAS: 9027-21-8
DBGET integrated database retrieval system