KEGG   ENZYME: 3.4.14.1Help
Entry
EC 3.4.14.1                 Enzyme                                 

Name
dipeptidyl-peptidase I;
cathepsin C;
dipeptidyl aminopeptidase I;
dipeptidyl transferase;
cathepsin C;
dipeptidyl transferase;
dipeptide arylamidase I;
DAP I
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
BRITE hierarchy
Reaction(IUBMB)
Release of an N-terminal dipeptide, Xaa-Yaa!Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro
Comment
A Cl--dependent, lysosomal cysteine-type peptidase maximally active at acidic pH. Also polymerizes dipeptide amides, arylamides and esters at neutral pH. In peptidase family C1 (papain family).
History
EC 3.4.14.1 created 1961 as EC 3.4.4.9, transferred 1972 to EC 3.4.14.1
Orthology
K01275  
cathepsin C
Genes
HSA: 
1075(CTSC)
PTR: 
451469(CTSC)
PPS: 
100987211(CTSC)
GGO: 
101146804(CTSC)
PON: 
100172530(CTSC)
NLE: 
100599280(CTSC)
MCC: 
705320(CTSC)
MCF: 
102137896(CTSC)
CJC: 
100400437(CTSC)
MMU: 
13032(Ctsc)
RNO: 
25423(Ctsc)
CGE: 
100769144(Ctsc)
HGL: 
101697606(Ctsc)
TUP: 
102488201(CTSC)
CFA: 
403458(CTSC)
AML: 
UMR: 
FCA: 
101092140(CTSC)
PTG: 
102956745(CTSC)
BTA: 
352958(CTSC)
BOM: 
102272716(CTSC)
PHD: 
102316892(CTSC)
CHX: 
102190937(CTSC)
OAS: 
101112686(CTSC)
SSC: 
100522387(CTSC)
CFR: 
102510887(CTSC)
BACU: 
103017877(CTSC)
LVE: 
103089091(CTSC)
ECB: 
100060401(CTSC)
MYB: 
102242588(CTSC)
MYD: 
102764432(CTSC)
PALE: 
102893721(CTSC)
MDO: 
SHR: 
OAA: 
100081326(CTSC)
GGA: 
419014(CTSC)
MGP: 
APLA: 
101805141(CTSC)
TGU: 
100230748(CTSC)
FAB: 
101814128(CTSC)
PHI: 
102104432(CTSC)
FPG: 
101918722(CTSC)
FCH: 
102058646(CTSC)
CLV: 
102095055(CTSC)
ASN: 
102386282(CTSC)
AMJ: 
102576717(CTSC)
PSS: 
102453891(CTSC)
CMY: 
102935389(CTSC)
ACS: 
100565042(ctsc)
PBI: 
103055898(CTSC)
XLA: 
380203(ctsc)
XTR: 
407938(ctsc)
DRE: 
368704(ctsc)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103184353(ctsc)
BFO: 
CIN: 
SPU: 
ISC: 
TSP: 
HRO: 
LGI: 
SMM: 
HMG: 
TAD: 
PFA: 
PFD: 
PFH: 
PYO: 
PCB: 
PBE: 
PKN: 
PVX: 
PCY: 
TAN: 
TPV: 
BBO: 
BBOV_I000540(16.m00694) BBOV_II000170(18.m05995)
BEQ: 
CPV: 
CHO: 
TGO: 
TET: 
PTM: 
NGR: 
GLA: 
 » show all
Taxonomy
Reference
1  [PMID:14209333]
  Authors
PLANTA RJ, GORTER J, GRUBER M.
  Title
THE CATALYTIC PROPERTIES OF CATHEPSIN C.
  Journal
Biochim. Biophys. Acta. 89 (1964) 511-9.
Reference
2  [PMID:5961281]
  Authors
Metroione RM, Neves AG, Fruton JS.
  Title
Purification and properties of dipeptidyl transferase (Cathepsin C).
  Journal
Biochemistry. 5 (1966) 1597-604.
Reference
3  [PMID:4306035]
  Authors
McDonald JK, Zeitman BB, Reilly TJ, Ellis S.
  Title
New observations on the substrate specificity of cathepsin C (dipeptidyl aminopeptidase I). Including the degradation of beta-corticotropin and other peptide hormones.
  Journal
J. Biol. Chem. 244 (1969) 2693-709.
Reference
4
  Authors
McDonald, J.K. and Schwabe, C.
  Title
Intracellular exopeptidases.
  Journal
In: Barrett, A.J. (Ed.), Proteinases in Mammalian Cells and Tissues, North-Holland Publishing Co., Amsterdam, 1977, p. 311-391.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9032-68-2

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