KEGG   ENZYME: 3.4.14.1Help
Entry
EC 3.4.14.1                 Enzyme                                 

Name
dipeptidyl-peptidase I;
cathepsin C;
dipeptidyl aminopeptidase I;
dipeptidyl transferase;
cathepsin C;
dipeptidyl transferase;
dipeptide arylamidase I;
DAP I
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
BRITE hierarchy
Reaction(IUBMB)
Release of an N-terminal dipeptide, Xaa-Yaa!Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro
Comment
A Cl--dependent, lysosomal cysteine-type peptidase maximally active at acidic pH. Also polymerizes dipeptide amides, arylamides and esters at neutral pH. In peptidase family C1 (papain family).
Orthology
K01275  
cathepsin C
Genes
HSA: 
1075(CTSC)
PTR: 
451469(CTSC)
PPS: 
100987211(CTSC)
GGO: 
101146804(CTSC)
PON: 
100172530(CTSC)
MCC: 
705320(CTSC)
MCF: 
102137896(CTSC)
MMU: 
13032(Ctsc)
RNO: 
25423(Ctsc)
CGE: 
HGL: 
101697606(Ctsc)
TUP: 
102488201(CTSC)
CFA: 
403458(CTSC)
AML: 
FCA: 
101092140(CTSC)
BTA: 
352958(CTSC)
BOM: 
102272716(CTSC)
PHD: 
102316892(CTSC)
CHX: 
102190937(CTSC)
SSC: 
100522387(CTSC)
CFR: 
102510887(CTSC)
ECB: 
100060401(CTSC)
MYB: 
102242588(CTSC)
MDO: 
SHR: 
OAA: 
GGA: 
419014(CTSC)
MGP: 
TGU: 
100230748(CTSC)
FAB: 
101814128(CTSC)
PHI: 
102104432(CTSC)
APLA: 
101805141(CTSC)
FPG: 
101918722(CTSC)
FCH: 
102058646(CTSC)
CLV: 
102095055(CTSC)
ASN: 
102386282(CTSC)
PSS: 
102453891(CTSC)
ACS: 
100565042(ctsc)
XLA: 
380203(ctsc)
XTR: 
407938(ctsc)
DRE: 
368704(ctsc)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
SPU: 
ISC: 
TSP: 
SMM: 
HMG: 
TAD: 
PFA: 
PFD: 
PFH: 
PYO: 
PCB: 
PBE: 
PKN: 
PVX: 
PCY: 
TAN: 
TPV: 
BBO: 
BBOV_I000540(16.m00694) BBOV_II000170(18.m05995)
BEQ: 
CPV: 
CHO: 
TGO: 
TET: 
PTM: 
NGR: 
GLA: 
 » show all
Taxonomy
Reference
1  [PMID:14209333]
  Authors
PLANTA RJ, GORTER J, GRUBER M.
  Title
THE CATALYTIC PROPERTIES OF CATHEPSIN C.
  Journal
Biochim. Biophys. Acta. 89 (1964) 511-9.
Reference
2  [PMID:5961281]
  Authors
Metroione RM, Neves AG, Fruton JS.
  Title
Purification and properties of dipeptidyl transferase (Cathepsin C).
  Journal
Biochemistry. 5 (1966) 1597-604.
  Organism
Bos taurus [GN:bta]
Reference
3  [PMID:4306035]
  Authors
McDonald JK, Zeitman BB, Reilly TJ, Ellis S.
  Title
New observations on the substrate specificity of cathepsin C (dipeptidyl aminopeptidase I). Including the degradation of beta-corticotropin and other peptide hormones.
  Journal
J. Biol. Chem. 244 (1969) 2693-709.
  Organism
Rattus norvegicus [GN:rno], Bos taurus [GN:bta]
Reference
4
  Authors
McDonald, J.K. and Schwabe, C.
  Title
Intracellular exopeptidases.
  Journal
In: Barrett, A.J. (Ed.), Proteinases in Mammalian Cells and Tissues, North-Holland Publishing Co., Amsterdam, 1977, p. 311-391.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9032-68-2

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