KEGG   ENZYME: 3.4.14.10Help
Entry
EC 3.4.14.10                Enzyme                                 

Name
tripeptidyl-peptidase II;
tripeptidyl aminopeptidase;
tripeptidyl peptidase;
tripeptidyl aminopeptidase II;
tripeptidyl peptidase II;
TPP
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
BRITE hierarchy
Reaction(IUBMB)
Release of an N-terminal tripeptide from a polypeptide
Comment
A cytosolic enzyme in peptidase family S8 (subtilisin family). Active at neutral pH. Inhibited by diisopropyl fluorophosphate. Formerly included in EC 3.4.14.8
History
EC 3.4.14.10 created 1992 (part of EC 3.4.14.8 created 1989, incorporated 1992)
Orthology
K01280  
tripeptidyl-peptidase II
Genes
HSA: 
7174(TPP2)
PTR: 
452645(TPP2)
PPS: 
100979697(TPP2)
GGO: 
101135379(TPP2)
PON: 
100172493(TPP2)
NLE: 
100581612(TPP2)
MCC: 
701311(TPP2)
MCF: 
CJC: 
100391991(TPP2)
MMU: 
22019(Tpp2)
RNO: 
81815(Tpp2)
CGE: 
100751018(Tpp2)
HGL: 
101700345(Tpp2)
TUP: 
102491918(TPP2)
CFA: 
100855853(TPP2)
AML: 
UMR: 
103657636(TPP2)
FCA: 
101082370(TPP2)
PTG: 
102969991(TPP2)
BTA: 
526052(TPP2)
BOM: 
102273977(TPP2)
PHD: 
102333369(TPP2)
CHX: 
102169112(TPP2)
OAS: 
101113507(TPP2)
SSC: 
CFR: 
102514630(TPP2)
BACU: 
103006667(TPP2)
LVE: 
103077108(TPP2)
ECB: 
100050973(TPP2)
MYB: 
102261518(TPP2)
MYD: 
102763719(TPP2)
PALE: 
102878730(TPP2)
MDO: 
100018913(TPP2)
SHR: 
100932521(TPP2)
OAA: 
100082920(TPP2)
GGA: 
428020(TPP2)
APLA: 
101800618(TPP2)
TGU: 
100221846(TPP2)
FAB: 
101820047(TPP2)
PHI: 
102108612(TPP2)
FPG: 
101917191(TPP2)
FCH: 
102051260(TPP2)
CLV: 
102092306(TPP2)
ASN: 
102383303(TPP2)
AMJ: 
102568353(TPP2)
PSS: 
102443431(TPP2)
CMY: 
102932230(TPP2)
ACS: 
100552517(tpp2)
PBI: 
103065222(TPP2)
XLA: 
443806(tpp2)
XTR: 
100101674(tpp2)
DRE: 
100331669(tpp2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102350093(TPP2)
CMK: 
BFO: 
CIN: 
100177474(tpp2)
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
412055(TppII)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
100631430(Tpp2)
ATH: 
AT4G20850(TPP2)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
101220162(TPP2)
CMO: 
RCU: 
POP: 
POPTR_0012s13100g(POPTRDRAFT_823475) POPTR_0015s13000g(POPTRDRAFT_776725)
VVI: 
100248019(TPP2)
SLY: 
SOT: 
OSA: 
DOSA: 
Os02t0664300-01(Os02g0664300)
OBR: 
BDI: 
100840642(TPP2)
SBI: 
SORBI_04g032510(SORBIDRAFT_04g032510)
SITA: 
ATR: 
s00009p00251110(AMTR_s00009p00251110)
SMO: 
PPP: 
CRE: 
VCN: 
CSL: 
CVR: 
CCP: 
SPO: 
UMA: 
PFP: 
MGL: 
MBR: 
ACAN: 
PTI: 
PIF: 
EHX: 
GTT: 
NGR: 
PBS: 
 » show all
Taxonomy
Reference
1  [PMID:6352701]
  Authors
Balow RM, Ragnarsson U, Zetterqvist O.
  Title
Tripeptidyl aminopeptidase in the extralysosomal fraction of rat liver.
  Journal
J. Biol. Chem. 258 (1983) 11622-8.
Reference
2  [PMID:3511062]
  Authors
Balow RM, Tomkinson B, Ragnarsson U, Zetterqvist O.
  Title
Purification, substrate specificity, and classification of tripeptidyl peptidase II.
  Journal
J. Biol. Chem. 261 (1986) 2409-17.
Reference
3  [PMID:1691635]
  Authors
Tomkinson B, Zetterqvist O.
  Title
Immunological cross-reactivity between human tripeptidyl peptidase II and fibronectin.
  Journal
Biochem. J. 267 (1990) 149-54.
  Sequence
[hsa:7174]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
101149-94-4

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