KEGG   ENZYME: 3.4.15.1Help
Entry
EC 3.4.15.1                 Enzyme                                 
Name
peptidyl-dipeptidase A;
dipeptidyl carboxypeptidase I;
peptidase P;
dipeptide hydrolase (ambiguous);
peptidyl dipeptidase;
angiotensin converting enzyme;
kininase II;
angiotensin I-converting enzyme;
carboxycathepsin;
dipeptidyl carboxypeptidase;
peptidyl dipeptidase I;
peptidyl-dipeptide hydrolase;
peptidyldipeptide hydrolase;
endothelial cell peptidyl dipeptidase;
ACE;
peptidyl dipeptidase-4;
PDH;
peptidyl dipeptide hydrolase;
DCP
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Peptidyl-dipeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of a C-terminal dipeptide, oligopeptide!Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II
Comment
A Cl--dependent, zinc glycoprotein that is generally membrane-bound. A potent inhibitor is captopril. Important in elevation of blood pressure, through formation of angiotensin II (vasoconstrictor) and destruction of bradykinin (vasodilator). Two molecular forms exist in mammalian tissues, a widely-distributed somatic form of 150- to 180-kDa that contains two non-identical catalytic sites, and a testicular form of 90- to 100-kDa that contains only a single catalytic site. Type example of peptidase family M2
Orthology
K01283  
peptidyl-dipeptidase A
Genes
HSA: 
1636(ACE)
PTR: 
449567(ACE)
PPS: 
GGO: 
PON: 
MCC: 
MMU: 
11421(Ace) 217246(Ace3)
RNO: 
24310(Ace) 498012(Ace3)
CFA: 
610668(ACE)
AML: 
FCA: 
101082864 101094061
BTA: 
100295485(ACE3) 509484(ACE)
SSC: 
100515049 613133(ACE)
ECB: 
100064801(ACE)
MDO: 
100025824
SHR: 
100932537 100932800
GGA: 
419953(ACE)
MGP: 
100542100
TGU: 
100217841(ACE)
ACS: 
100558092
XTR: 
100144634(ace)
DRE: 
565980(ace)
TRU: 
101076790
OLA: 
101172772
BFO: 
BRAFLDRAFT_246631 BRAFLDRAFT_287032
CIN: 
100180899
SPU: 
593501 593528
DME: 
Dmel_CG10142(Ance-5) Dmel_CG10593(Acer) Dmel_CG16869(Ance-2) Dmel_CG17988(Ance-3) Dmel_CG8196(Ance-4) Dmel_CG8827(Ance)
DPO: 
Dpse_GA10105 Dpse_GA10423 Dpse_GA20888 Dpse_GA28777 Dpse_GA28778 Dpse_GA28780
DAN: 
Dana_GF11532 Dana_GF12717 Dana_GF14268 Dana_GF14269 Dana_GF14270 Dana_GF15534
DER: 
Dere_GG10593 Dere_GG19880 Dere_GG23895 Dere_GG23896 Dere_GG23898 Dere_GG25294
DPE: 
Dper_GL10903 Dper_GL16859 Dper_GL21244 Dper_GL21247 Dper_GL21250 Dper_GL26134
DSE: 
Dsec_GM11782 Dsec_GM15352 Dsec_GM15363 Dsec_GM15385 Dsec_GM17055 Dsec_GM20639
DSI: 
Dsim_GD10112 Dsim_GD23554 Dsim_GD23936 Dsim_GD23937 Dsim_GD23939 Dsim_GD24910
DWI: 
Dwil_GK15019 Dwil_GK15020 Dwil_GK15021 Dwil_GK18674 Dwil_GK20737
DYA: 
Dyak_GE11404 Dyak_GE18694 Dyak_GE18695 Dyak_GE18785 Dyak_GE19012 Dyak_GE22653
DGR: 
Dgri_GH10960 Dgri_GH11125 Dgri_GH11126 Dgri_GH11127 Dgri_GH20259 Dgri_GH21978
DMO: 
Dmoj_GI10464 Dmoj_GI12636 Dmoj_GI12647 Dmoj_GI19428 Dmoj_GI19680
DVI: 
Dvir_GJ17191 Dvir_GJ18156 Dvir_GJ18157 Dvir_GJ18158 Dvir_GJ21182 Dvir_GJ21681
AGA: 
AgaP_AGAP004563(ANCE9) AgaP_AGAP009751(ANCE2) AgaP_AGAP009754(ANCE4) AgaP_AGAP009755(ANCE5) AgaP_AGAP009756(ANCE6) AgaP_AGAP009757(ANCE7)
AAG: 
AaeL_AAEL002676 AaeL_AAEL009310 AaeL_AAEL009316
CQU: 
CpipJ_CPIJ004086 CpipJ_CPIJ009106 CpipJ_CPIJ009107 CpipJ_CPIJ009108
AME: 
408536 410074
NVI: 
100118011(NV12891) 100123549(NV13720)
TCA: 
658047 658170(Ance-3) 663638
API: 
100164692 100166321 100168185(Ance-like)
PHU: 
Phum_PHUM034490 Phum_PHUM522390
ISC: 
IscW_ISCW005573
CEL: 
CELE_C42D8.5(acn-1)
CBR: 
CBG14607(Cbr-acn-1)
BMY: 
Bm1_31085
TSP: 
Tsp_01435
NVE: 
NEMVE_v1g190941 NEMVE_v1g210990
HMG: 
100210213
TAD: 
TRIADDRAFT_37492
XCC: 
XCC1116
XCB: 
XC_3130
XCA: 
xccb100_3225
XCV: 
XCV1249
XCP: 
XCR_1338
XAC: 
XAC1217
XAX: 
XACM_1192
XAO: 
XAC29_06115
XOO: 
XOO3539
XOM: 
XOO_3345
XOP: 
PXO_04473
XOR: 
XOC_1282
XAL: 
XALc_0887
XCI: 
XCAW_03136
SML: 
Smlt3574
SMT: 
Smal_2996
BUJ: 
BurJV3_3026
SMZ: 
SMD_3147
PSU: 
Psesu_2161
PSD: 
DSC_06070
SON: 
SO_2494
SDN: 
Sden_2117
SFR: 
Sfri_1887
SAZ: 
Sama_1817
SBL: 
Sbal_2246 Sbal_4532
SBM: 
Shew185_2125
SBN: 
Sbal195_2170
SBP: 
Sbal223_2259
SBT: 
Sbal678_2173
SBS: 
Sbal117_2369
SBB: 
Sbal175_2295
SLO: 
Shew_2053
SSE: 
Ssed_2057
SPL: 
Spea_2340
SHE: 
Shewmr4_2051
SHM: 
Shewmr7_1924
SHN: 
Shewana3_2002 Shewana3_2156
SWD: 
Swoo_2544
SWP: 
swp_2383
SVO: 
SVI_2322
CPS: 
CPS_1585
AMC: 
MADE_1008755
AMAC: 
MASE_07965
AMB: 
AMBAS45_08550
AMG: 
AMEC673_08055
AMK: 
AMBLS11_07960
AMAA: 
amad1_09155
ALT: 
ambt_09930
GAG: 
Glaag_2085
GNI: 
GNIT_1032
TTU: 
TERTU_2099
LLO: 
LLO_1982
KKO: 
Kkor_1388
SAGA: 
M5M_17395
ADE: 
Adeh_2024
ACP: 
A2cp1_1939
AFW: 
Anae109_1785
ANK: 
AnaeK_1854
MXA: 
MXAN_3581
MFU: 
LILAB_25885
MSD: 
MYSTI_04371
CCX: 
COCOR_04454
SUR: 
STAUR_4119
SCL: 
sce3979 sce5088
HOH: 
Hoch_6422
CAK: 
Caul_0184
PZU: 
PHZ_c0316
AEX: 
Astex_0409
PSF: 
PSE_0360
MMR: 
Mmar10_1467
HNE: 
HNE_1947
HBA: 
Hbal_0598
NPP: 
PP1Y_AT21138
SAL: 
Sala_0456
SWI: 
Swit_2667
SPHM: 
G432_00930
SSY: 
SLG_23650
ELI: 
ELI_07405
ABA: 
Acid345_4468
TSA: 
AciPR4_3174
TRS: 
Terro_0304
SUS: 
Acid_4844
OHO: 
Oweho_1053
SACI: 
Sinac_2369
GVI: 
gll3143
CEX: 
CSE_15400
 » show all
Taxonomy
Reference
1  [PMID:2849100]
  Authors
Soubrier F, Alhenc-Gelas F, Hubert C, Allegrini J, John M, Tregear G, Corvol P.
  Title
Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 9386-90.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:2554286]
  Authors
Ehlers MR, Fox EA, Strydom DJ, Riordan JF.
  Title
Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 86 (1989) 7741-5.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:1320019]
  Authors
Wei L, Clauser E, Alhenc-Gelas F, Corvol P.
  Title
The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors.
  Journal
J. Biol. Chem. 267 (1992) 13398-405.
  Organism
Homo sapiens [GN:hsa]
Reference
4  [PMID:7674927]
  Authors
Corvol P, Williams TA, Soubrier F.
  Title
Peptidyl dipeptidase A: angiotensin I-converting enzyme.
  Journal
Methods. Enzymol. 248 (1995) 283-305.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9015-82-1
DBGET integrated database retrieval system