KEGG   ENZYME: 3.4.16.5Help
Entry
EC 3.4.16.5                 Enzyme                                 

Name
carboxypeptidase C;
carboxypeptidase Y;
serine carboxypeptidase I;
cathepsin A;
lysosomal protective protein;
deamidase;
lysosomal carboxypeptidase A;
phaseolin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine-type carboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of a C-terminal amino acid with broad specificity
Comment
A carboxypeptidase with optimum pH 4.5-6.0, inhibited by diisopropyl fluorophosphate, and sensitive to thiol-blocking reagents (reviewed in [1]). Widely distributed in eukaryotes. Type example of peptidase family S10.
History
EC 3.4.16.5 created 1972 as EC 3.4.12.1, transferred 1978 to EC 3.4.16.1, part transferred 1993 to EC 3.4.16.5 (EC 3.4.16.3 created 1972 as EC 3.4.12.12, transferred 1978 to EC 3.4.16.3, transferred 1992 to EC 3.4.16.1), (EC 3.4.21.13 created 1972, transferred 1978 to EC 3.4.16.1)
Orthology
K13289  
cathepsin A (carboxypeptidase C)
Genes
HSA: 
5476(CTSA)
PTR: 
458290(CTSA)
PPS: 
100969338(CTSA)
GGO: 
101150972(CTSA)
PON: 
100173381(CTSA)
MCC: 
708592(CTSA)
MCF: 
MMU: 
19025(Ctsa)
RNO: 
296370(Ctsa)
CGE: 
100772055(Ctsa)
HGL: 
101720484(Ctsa)
TUP: 
102485953(CTSA)
CFA: 
611146(CTSA)
AML: 
100474665(CTSA)
FCA: 
101085538(CTSA)
PTG: 
102958713(CTSA)
BTA: 
518169(CTSA)
BOM: 
102280027(CTSA)
PHD: 
102322563(CTSA)
CHX: 
102182324(CTSA)
SSC: 
100156798(CTSA)
CFR: 
102508708(CTSA)
BACU: 
103017862(CTSA)
LVE: 
103087262(CTSA)
ECB: 
100071127(CTSA)
MYB: 
102259776(CTSA)
MYD: 
102766118(CTSA)
PALE: 
102888117(CTSA)
MDO: 
SHR: 
OAA: 
100076065(CTSA)
GGA: 
428163(CTSA)
MGP: 
TGU: 
100220062(CTSA)
FAB: 
101812393(CTSA)
PHI: 
102113628(CTSA)
APLA: 
101801880(CTSA)
FPG: 
101912460(CTSA)
FCH: 
102045880(CTSA)
CLV: 
102087924(CTSA)
ASN: 
102373938(CTSA)
AMJ: 
102564952(CTSA)
PSS: 
102460692(CTSA)
ACS: 
XLA: 
494810(ctsa)
XTR: 
734066(ctsa)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102354641(CTSA)
BFO: 
CIN: 
SPU: 
CEL: 
CELE_F13D12.6(F13D12.6) CELE_F41C3.5(F41C3.5) CELE_Y16B4A.2(Y16B4A.2) CELE_Y40D12A.2(Y40D12A.2)
CBR: 
BMY: 
LOA: 
SMM: 
TAD: 
OTA: 
SCE: 
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0F02120(NCAS0F02120) NCAS_0I02290(NCAS0I02290)
NDI: 
NDAI_0A06870(NDAI0A06870) NDAI_0C03670(NDAI0C03670)
TPF: 
TPHA_0A05520(TPHA0A05520)
TBL: 
TBLA_0C06920(TBLA0C06920)
TDL: 
TDEL_0G00500(TDEL0G00500)
KAF: 
KAFR_0I02520(KAFR0I02520)
DHA: 
PIC: 
PGU: 
LEL: 
CAL: 
CaO19.10011(CPY2) CaO19.11612(CPY3) CaO19.1339(CPY1) CaO19.2474(CPY2) CaO19.4135(CPY3) CaO19.8919(CPY1) CaO19_1339(CaJ7_0388)
CTP: 
COT: 
CDU: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
MAW: 
MAJ: 
SSL: 
BFU: 
ANI: 
AFM: 
AOR: 
AOR_1_542034(AO090103000332)
ANG: 
ANI_1_1208074(An08g08750) ANI_1_238044(An05g01870)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
ZTR: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
PPL: 
LBC: 
MPR: 
CCI: 
SCM: 
UMA: 
MGL: 
PGR: 
MBR: 
DDI: 
TET: 
PTM: 
PTI: 
TPS: 
PIF: 
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
LLO: 
 » show all
Taxonomy
Reference
1
  Authors
Breddam, K.
  Title
Serine carboxypeptidases. A review.
  Journal
Carlsberg Res. Commun. 51 (1986) 83-128.
Reference
2  [PMID:3028649]
  Authors
Valls LA, Hunter CP, Rothman JH, Stevens TH.
  Title
Protein sorting in yeast: the localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide.
  Journal
Cell. 48 (1987) 887-97.
  Organism
Saccharomyces cerevisiae
  Sequence
[sce:YMR297W]
Reference
3  [PMID:1737744]
  Authors
Jackman HL, Morris PW, Deddish PA, Skidgel RA, Erdos EG.
  Title
Inactivation of endothelin I by deamidase (lysosomal protective protein).
  Journal
J. Biol. Chem. 267 (1992) 2872-5.
  Organism
Homo sapiens
Reference
4  [PMID:1487525]
  Authors
Miller JJ, Changaris DG, Levy RS.
  Title
Purification, subunit structure and inhibitor profile of cathepsin A.
  Journal
J. Chromatogr. 627 (1992) 153-62.
  Organism
Sus scofa
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9046-67-7

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