KEGG   ENZYME: 3.4.17.23Help
Entry
EC 3.4.17.23                Enzyme                                 
Name
angiotensin-converting enzyme 2;
ACE-2;
ACE2;
hACE2;
angiotensin converting enzyme 2;
angiotensin converting enzyme-2;
Tmem27
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
angiotensin II + H2O = angiotensin-(1--7) + L-phenylalanine [RN:R09535]
Reaction(KEGG)
Substrate
angiotensin II [CPD:C02135];
H2O [CPD:C00001]
Product
angiotensin-(1--7);
L-phenylalanine [CPD:C00079]
Comment
A transmembrane glycoprotein with an extracellular catalytic domain. Angiotensin-converting enzyme 2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates [2]. Catalytic efficiency is 400-fold higher with angiotensin II (1--8) as a substrate than with angiotensin I (1--10). Angiotensin-converting enzyme 2 also efficiently hydrolyses des-Arg9-bradykinin, but it does not hydrolyse bradykinin [1]. In peptidase family M2.
Orthology
K09708  
angiotensin-converting enzyme 2
Genes
HSA: 
59272(ACE2)
PTR: 
465511(ACE2)
PPS: 
100970340(ACE2)
GGO: 
101142534(ACE2)
PON: 
100171441(ACE2)
MCC: 
712790(ACE2)
MMU: 
70008(Ace2)
RNO: 
302668(Ace2)
CFA: 
480847(ACE2)
AML: 
FCA: 
554349(ACE2)
BTA: 
509235(ACE2)
SSC: 
100144303(ACE2)
ECB: 
100055952
MDO: 
100031783
SHR: 
100917420(ACE2)
OAA: 
100085223
GGA: 
418623(ACE2)
TGU: 
100232752(ACE2)
ACS: 
100565298
XTR: 
100486137
DRE: 
492331(ace2)
TRU: 
101066589
OLA: 
101175124
SPU: 
577312
 » show all
Taxonomy
Reference
1  [PMID:11815627]
  Authors
Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, Godbout K, Parsons T, Baronas E, Hsieh F, Acton S, Patane M, Nichols A, Tummino P
  Title
Hydrolysis of biological peptides by human angiotensin-converting enzyme-related  carboxypeptidase.
  Journal
J. Biol. Chem. 277 (2002) 14838-43.
Reference
2  [PMID:17897633]
  Authors
Lambert DW, Hooper NM, Turner AJ
  Title
Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system.
  Journal
Biochem. Pharmacol. 75 (2008) 781-6.
Reference
3  [PMID:14754895]
  Authors
Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW
  Title
ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.
  Journal
J. Biol. Chem. 279 (2004) 17996-8007.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system