KEGG   ENZYME: 3.4.17.3Help
Entry
EC 3.4.17.3                 Enzyme                                 

Name
lysine carboxypeptidase;
carboxypeptidase N;
arginine carboxypeptidase;
kininase I;
anaphylatoxin inactivator;
plasma carboxypeptidase B;
creatine kinase conversion factor;
bradykinase;
kininase Ia;
hippuryllysine hydrolase;
bradykinin-decomposing enzyme;
protaminase;
CPase N;
creatinine kinase convertase;
peptidyl-L-lysine(-L-arginine) hydrolase;
CPN
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of a C-terminal basic amino acid, preferentially lysine
Comment
A zinc enzyme found in plasma. Inactivates bradykinin and anaphylatoxins in blood plasma. In peptidase family M14 (carboxypeptidase A family).
History
EC 3.4.17.3 created 1972 as EC 3.4.12.7, transferred 1978 to EC 3.4.17.3, modified 1989
Orthology
K01292  
carboxypeptidase N catalytic subunit
Genes
HSA: 
1369(CPN1)
PPS: 
100994885(CPN1)
GGO: 
101136315(CPN1)
PON: 
100448102(CPN1)
MCC: 
709434(CPN1)
MCF: 
102146119(CPN1)
MMU: 
93721(Cpn1)
RNO: 
365466(Cpn1)
CGE: 
100752048(Cpn1)
HGL: 
101718051(Cpn1)
TUP: 
102499941(CPN1)
CFA: 
477795(CPN1)
AML: 
FCA: 
101090390(CPN1)
PTG: 
102973010(CPN1)
BTA: 
536753(CPN1)
BOM: 
102283003(CPN1)
PHD: 
102336544(CPN1)
CHX: 
102180453(CPN1)
SSC: 
100157984(CPN1)
CFR: 
102505284(CPN1)
BACU: 
103018234(CPN1)
LVE: 
103083659(CPN1)
ECB: 
100070412(CPN1)
MYB: 
102262371(CPN1)
MYD: 
102761933(CPN1)
PALE: 
102894046(CPN1)
MDO: 
100020383(CPN1)
SHR: 
100924516(CPN1)
GGA: 
769143(CPN1)
MGP: 
TGU: 
100231475(CPN1)
FAB: 
101818188(CPN1)
PHI: 
102110254(CPN1)
APLA: 
101803617(CPN1)
FPG: 
101919893(CPN1)
FCH: 
102053681(CPN1)
CLV: 
102095577(CPN1)
ASN: 
102373779(CPN1)
AMJ: 
102567467(CPN1)
PSS: 
102453241(CPN1)
CMY: 
102944605(CPN1)
ACS: 
PBI: 
103054238(CPN1)
XLA: 
398791(cpn1)
XTR: 
550020(cpn1)
DRE: 
337172(cpn1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102367336(CPN1)
CMK: 
103186570(cpn1)
BFO: 
 » show all
Taxonomy
Reference
1  [PMID:7341915]
  Authors
Plummer TH Jr, Erdos EG.
  Title
Human plasma carboxypeptidase N.
  Journal
Methods. Enzymol. 80 Pt C (1981) 442-9.
  Organism
Homo sapiens
Reference
2  [PMID:6750606]
  Authors
Levin Y, Skidgel RA, Erdos EG.
  Title
Isolation and characterization of the subunits of human plasma carboxypeptidase N (kininase i).
  Journal
Proc. Natl. Acad. Sci. U. S. A. 79 (1982) 4618-22.
  Organism
Homo sapiens
Reference
3  [PMID:3074547]
  Authors
Skidgel RA.
  Title
Basic carboxypeptidases: regulators of peptide hormone activity.
  Journal
Trends. Pharmacol. Sci. 9 (1988) 299-304.
  Organism
Homo sapiens
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9013-89-2

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