KEGG   ENZYME: 3.4.18.1Help
Entry
EC 3.4.18.1                 Enzyme                                 
Name
cathepsin X;
cathepsin B2;
cysteine-type carboxypeptidase;
cathepsin IV;
cathepsin Z;
acid carboxypeptidase;
lysosomal carboxypeptidase B
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine-type carboxypeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity
Comment
Cathepsin X is a lysosomal cysteine peptidase of family C1 (papain family). The pH optimum is dependent on the substrate and is 5.0 for the carboxypeptidase activity. Unstable above pH 7.0. Compound E-64, leupeptin and antipain are inhibitors, but not cystatin C. Cathepsin X is ubiquitously distributed in mammalian tissues. The propeptide is extremely short (38 amino acid residues) and the proenzyme is catalytically active. Human gene locus: 20q13.
Orthology
K08568  
cathepsin X
Genes
HSA: 
1522(CTSZ)
PTR: 
736240(CTSZ)
PPS: 
100978982(CTSZ)
GGO: 
101135556(CTSZ)
PON: 
100445547(CTSZ)
MMU: 
64138(Ctsz)
RNO: 
252929(Ctsz)
CFA: 
611983(CTSZ)
AML: 
FCA: 
101087983(CTSZ)
BTA: 
404187(CTSZ)
SSC: 
100141405(CTSZ)
ECB: 
100056600
MDO: 
100027054
SHR: 
100927306(CTSZ)
OAA: 
100080444
GGA: 
419311(CTSZ)
MGP: 
100550055
TGU: 
100222997(CTSZ) 100225523
ACS: 
100559555
XLA: 
432187 494800(ctsz)
XTR: 
100127597(ctsz)
DRE: 
450022(ctsz)
TRU: 
101077965
OLA: 
101171361
BFO: 
BRAFLDRAFT_126693
SPU: 
580617 583170
CEL: 
CELE_F32B5.8(cpz-1) CELE_M04G12.2(cpz-2)
CBR: 
CBG04105(Cbr-cpz-1) CBG06727(Cbr-cpz-2)
BMY: 
Bm1_30360 Bm1_56735
TSP: 
Tsp_10493
NVE: 
NEMVE_v1g117667 NEMVE_v1g117697
HMG: 
100208353
AQU: 
100632176
PPP: 
PHYPADRAFT_168203
CRE: 
CHLREDRAFT_108071
VCN: 
VOLCADRAFT_120530
OLU: 
OSTLU_39605
OTA: 
Ot01g04810
MBR: 
MONBRDRAFT_34651 MONBRDRAFT_9815
NGR: 
NAEGRDRAFT_62623 NAEGRDRAFT_82224
DDI: 
DDB_G0280187 DDB_G0283401(ctsZ)
DPP: 
DICPUDRAFT_44383
TET: 
TTHERM_00102770 TTHERM_00102779
PTM: 
GSPATT00017357001
PTI: 
PHATRDRAFT_43432 PHATRDRAFT_4741 PHATRDRAFT_4936
TPS: 
THAPSDRAFT_263404 THAPSDRAFT_268564 THAPSDRAFT_38360
PIF: 
PITG_02423
 » show all
Taxonomy
Reference
1  [PMID:10504234]
  Authors
Nagler DK, Zhang R, Tam W, Sulea T, Purisima EO, Menard R
  Title
Human cathepsin X: A cysteine protease with unique carboxypeptidase activity.
  Journal
Biochemistry. 38 (1999) 12648-54.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:9738465]
  Authors
Nagler DK, Menard R.
  Title
Human cathepsin X: a novel cysteine protease of the papain family with a very short proregion and unique insertions.
  Journal
FEBS. Lett. 434 (1998) 135-9.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:9642240]
  Authors
Santamaria I, Velasco G, Pendas AM, Fueyo A, Lopez-Otin C.
  Title
Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location.
  Journal
J. Biol. Chem. 273 (1998) 16816-23.
Reference
4  [PMID:577]
  Authors
McDonald JK, Ellis S.
  Title
On the substrate specificity of cathepsins B1 and B2 including a new fluorogenic substrate for cathepsin B1.
  Journal
Life. Sci. 17 (1975) 1269-76.
  Organism
Bos taurus [GN:bta]
Reference
5  [PMID:1122298]
  Authors
Otto K, Riesenkonig H.
  Title
Improved purification of cathepsin B1 and cathepsin B2.
  Journal
Biochim. Biophys. Acta. 379 (1975) 462-75.
  Organism
Bos taurus [GN:bta]
Reference
6  [PMID:4429705]
  Authors
Ninjoor V, Taylor SL, Tappel AL.
  Title
Purification and characterization of rat liver lysosomal cathepsin B2.
  Journal
Biochim. Biophys. Acta. 370 (1974) 308-21.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37217-21-3
DBGET integrated database retrieval system