mannan-binding lectin-associated serine protease-2;
MASP-2;
MASP2;
MBP-associated serine protease-2;
mannose-binding lectin-associated serine protease-2;
p100;
mannan-binding lectin-associated serine peptidase 2

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg!Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg!Ala-Leu-Glu-Ile)

Mannan-binding lectin (MBL) recognizes patterns of neutral carbohydrates, such as mannose and N-acetylglucosamine, on a wide range of microbial surfaces and is able to initiate activation of the lectin pathway of complement [7]. This enzyme displays C_overbar_1s_-like esterolytic activity (cf. EC 3.4.21.42, complement subcomponent C_overbar_1s_). It also cleaves C4 and C2 with efficiencies that are relatively higher than those of EC 3.4.21.42 [3]. Belongs in peptidase family S1A.

1  [PMID:1460414]

Matsushita M, Fujita T.

Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease.

J. Exp. Med. 176 (1992) 1497-502.

Homo sapiens [GN:hsa]

2  [PMID:9087411]

Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, Reid KB, Jensenius JC.

A second serine protease associated with mannan-binding lectin that activates complement.

Nature. 386 (1997) 506-10.

Homo sapiens [GN:hsa]

3  [PMID:11527969]

Rossi V, Cseh S, Bally I, Thielens NM, Jensenius JC, Arlaud GJ.

Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2.

J. Biol. Chem. 276 (2001) 40880-7.

Homo sapiens [GN:hsa]

4  [PMID:12538697]

Ambrus G, Gal P, Kojima M, Szilagyi K, Balczer J, Antal J, Graf L, Laich A, Moffatt BE, Schwaeble W, Sim RB, Zavodszky P.

Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments.

J. Immunol. 170 (2003) 1374-82.

Homo sapiens [GN:hsa]

5  [PMID:15364579]

Harmat V, Gal P, Kardos J, Szilagyi K, Ambrus G, Vegh B, Naray-Szabo G, Zavodszky P.

The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions.

J. Mol. Biol. 342 (2004) 1533-46.

Homo sapiens [GN:hsa]

6  [PMID:15060079]

Chen CB, Wallis R.

Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases.

J. Biol. Chem. 279 (2004) 26058-65.

Homo sapiens [GN:hsa]

7  [PMID:15728497]

Teillet F, Dublet B, Andrieu JP, Gaboriaud C, Arlaud GJ, Thielens NM.

The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases.

J. Immunol. 174 (2005) 2870-7.

Homo sapiens [GN:hsa]