KEGG   ENZYME: 3.4.21.106Help
Entry
EC 3.4.21.106               Enzyme                                 

Name
hepsin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys
Comment
This type-II membrane-associated serine peptidase has been implicated in cell growth and development [1,3]. The enzyme has been shown to activate blood coagulation factor VII by cleavage of the Arg152!Ile153 peptide bound in BHK cells, thus indicating a possible role in the initiation of blood coagulation [2]. There is no cleavage after aromatic or aliphatic residues [1]. The occupancy of the S2 site is an absolute requirement for catalysis and a basic residue at that site is preferred to an aliphatic residue. The nature of the residue at S3 also affects hydrolysis, with Gln being much more favourable than Ala [1]. Belongs in peptidase family S1A.
History
EC 3.4.21.106 created 2006
Orthology
K08665  hepsin
Genes
HSA: 3249(HPN)
PTR: 455944(HPN)
PPS: 100987098(HPN)
GGO: 101135897(HPN)
PON: 100173788(HPN)
NLE: 100591395(HPN)
MCC: 707242(HPN)
MCF: 102120705(HPN)
CSAB: 103234489(HPN)
RRO: 104667121(HPN)
RBB: 108512302(HPN)
CJC: 100401729(HPN)
SBQ: 101040717(HPN)
MMU: 15451(Hpn)
RNO: 29135(Hpn)
CGE: 100757163(Hpn)
NGI: 103729906(Hpn)
HGL: 101708013(Hpn)
CCAN: 109694561(Hpn)
OCU: 100345382(HPN)
TUP: 102472167(HPN)
CFA: 484583(HPN)
AML: 100473121(HPN)
UMR: 103682491(HPN)
ORO: 101374485(HPN)
FCA: 101099007(HPN)
PTG: 102961568(HPN)
AJU: 106974756(HPN)
BTA: 508148(HPN)
BOM: 102265892(HPN)
BIU: 109572366(HPN)
PHD: 102327195(HPN)
CHX: 102188889(HPN)
OAS: 101117692(HPN)
SSC: 100624088(HPN)
CFR: 102522484(HPN)
CDK: 105088028(HPN)
BACU: 103014212(HPN)
LVE: 103089245(HPN)
OOR: 101279617(HPN)
ECB: 100058873(HPN)
EPZ: 103547718(HPN)
EAI: 106829219(HPN)
MYB: 102254751(HPN)
MYD: 102771439(HPN)
HAI: 109372038(HPN)
RSS: 109433992(HPN)
PALE: 102898712(HPN)
LAV: 100673906(HPN)
TMU: 101353096
MDO: 100015125(HPN)
SHR: 100924033(HPN)
ASN: 102385148(HPN)
AMJ: 102570449(HPN)
PSS: 102443380(HPN)
CMY: 102934816
CPIC: 101951444(HPN)
ACS: 100553659(hpn)
PVT: 110070730(HPN)
PBI: 103059263(HPN)
GJA: 107119876(HPN)
XLA: 108697289(hpn.S) 108705714
XTR: 100145343(hpn)
NPR: 108798671(HPN)
DRE: 569259(si:dkey-33i11.3)
SANH: 107665644 107666884(hpn)
IPU: 108256296(hpn)
AMEX: 103024311
LCO: 104928115(hpn)
NCC: 104962735(hpn)
MZE: 101473962(hpn)
OLA: 101171277(hpn)
XMA: 102234257(hpn)
PRET: 103478304(hpn)
NFU: 107378964(hpn)
CSEM: 103388772(hpn)
LCF: 108888185(hpn)
HCQ: 109529638(hpn)
BPEC: 110171625
ELS: 105019132(hpn)
SFM: 108919201(hpn)
LCM: 102358874(HPN)
 » show all
Taxonomy
Reference
1  [PMID:9003440]
  Authors
Zhukov A, Hellman U, Ingelman-Sundberg M.
  Title
Purification and characterization of hepsin from rat liver microsomes.
  Journal
Biochim. Biophys. Acta. 1337 (1997) 85-95.
Reference
2  [PMID:7814421]
  Authors
Kazama Y, Hamamoto T, Foster DC, Kisiel W.
  Title
Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation.
  Journal
J. Biol. Chem. 270 (1995) 66-72.
Reference
3  [PMID:8346233]
  Authors
Torres-Rosado A, O'Shea KS, Tsuji A, Chou SH, Kurachi K.
  Title
Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 7181-5.
  Sequence
[hsa:3249]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.106
IUBMB Enzyme Nomenclature: 3.4.21.106
ExPASy - ENZYME nomenclature database: 3.4.21.106
BRENDA, the Enzyme Database: 3.4.21.106
CAS: 112398-23-9

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