KEGG   ENZYME: 3.4.21.108Help
Entry
EC 3.4.21.108               Enzyme                                 
Name
HtrA2 peptidase;
high temperature requirement protein A2;
HtrA2;
Omi stress-regulated endoprotease;
serine proteinase OMI;
HtrA2 protease;
OMI/HtrA2 protease;
HtrA2/Omi;
Omi/HtrA2
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues
Comment
This enzyme is upregulated in mammalian cells in response to stress induced by both heat shock and tunicamycin treatment [4]. It can induce apoptosis in a caspase-independent manner through its peptidase activity and in a caspase-dependent manner by disrupting the interaction between caspase and the inhibitor of apoptosis (IAP) [3]. Belongs in peptidase family S1C.
Orthology
K08669  
HtrA serine peptidase 2
Genes
HSA: 
27429(HTRA2)
PTR: 
459339(HTRA2)
PPS: 
100985283(HTRA2)
GGO: 
101153780(HTRA2)
PON: 
100461940(HTRA2)
MCC: 
709938(HTRA2)
MMU: 
64704(Htra2)
RNO: 
297376(Htra2)
CFA: 
475782(HTRA2)
AML: 
FCA: 
768259(HTRA2)
BTA: 
523039(HTRA2)
SSC: 
100512831 100628090
ECB: 
100053688
MDO: 
100025882
GGA: 
395990(HTRA2)
MGP: 
100538527
ACS: 
100565079
XTR: 
100337648
DRE: 
100137109 560917
TRU: 
101079124
OLA: 
101174474
BFO: 
BRAFLDRAFT_124691
SPU: 
756975
DME: 
Dmel_CG8464(HtrA2)
DPO: 
Dpse_GA21097
DAN: 
Dana_GF17480
DER: 
Dere_GG21285
DPE: 
Dper_GL24014
DSE: 
Dsec_GM25850
DSI: 
Dsim_GD20417
DWI: 
Dwil_GK12147
DYA: 
Dyak_GE26447
DGR: 
Dgri_GH13631
DMO: 
Dmoj_GI24802
DVI: 
Dvir_GJ24448
AGA: 
AgaP_AGAP000240
AAG: 
AaeL_AAEL006373
CQU: 
CpipJ_CPIJ005160
AME: 
551969(HtrA2)
NVI: 
100122950(NV11522)
TCA: 
657089
PHU: 
Phum_PHUM529710
ISC: 
IscW_ISCW020167
TSP: 
Tsp_09197 Tsp_09212
AQU: 
100637088
PIF: 
PITG_03582
 » show all
Taxonomy
Reference
1  [PMID:12835328]
  Authors
Srinivasula SM, Gupta S, Datta P, Zhang Z, Hegde R, Cheong N, Fernandes-Alnemri T, Alnemri ES.
  Title
Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2.
  Journal
J. Biol. Chem. 278 (2003) 31469-72.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:10873535]
  Authors
Savopoulos JW, Carter PS, Turconi S, Pettman GR, Karran EH, Gray CW, Ward RV, Jenkins O, Creasy CL.
  Title
Expression, purification, and functional analysis of the human serine protease HtrA2.
  Journal
Protein. Expr. Purif. 19 (2000) 227-34.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:14512424]
  Authors
Martins LM, Turk BE, Cowling V, Borg A, Jarrell ET, Cantley LC, Downward J.
  Title
Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi.
  Journal
J. Biol. Chem. 278 (2003) 49417-27.
  Organism
Homo sapiens [GN:hsa]
Reference
4  [PMID:10971580]
  Authors
Gray CW, Ward RV, Karran E, Turconi S, Rowles A, Viglienghi D, Southan C, Barton A, Fantom KG, West A, Savopoulos J, Hassan NJ, Clinkenbeard H, Hanning C, Amegadzie B, Davis JB, Dingwall C, Livi GP, Creasy CL.
  Title
Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response.
  Journal
Eur. J. Biochem. 267 (2000) 5699-710.
  Organism
Homo sapiens [GN:hsa]
Reference
5  [PMID:11967569]
  Authors
Li W, Srinivasula SM, Chai J, Li P, Wu JW, Zhang Z, Alnemri ES, Shi Y.
  Title
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi.
  Journal
Nat. Struct. Biol. 9 (2002) 436-41.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system