KEGG   ENZYME: 3.4.21.108Help
Entry
EC 3.4.21.108               Enzyme                                 

Name
HtrA2 peptidase;
high temperature requirement protein A2;
HtrA2;
Omi stress-regulated endoprotease;
serine proteinase OMI;
HtrA2 protease;
OMI/HtrA2 protease;
HtrA2/Omi;
Omi/HtrA2
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues
Comment
This enzyme is upregulated in mammalian cells in response to stress induced by both heat shock and tunicamycin treatment [4]. It can induce apoptosis in a caspase-independent manner through its peptidase activity and in a caspase-dependent manner by disrupting the interaction between caspase and the inhibitor of apoptosis (IAP) [3]. Belongs in peptidase family S1C.
History
EC 3.4.21.108 created 2006
Orthology
K08669  
HtrA serine peptidase 2
Genes
HSA: 
27429(HTRA2)
PTR: 
459339(HTRA2)
PPS: 
100985283(HTRA2)
GGO: 
101153780(HTRA2)
PON: 
100461940(HTRA2)
MCC: 
709938(HTRA2)
MCF: 
102126403(HTRA2)
MMU: 
64704(Htra2)
RNO: 
297376(Htra2)
CGE: 
100760629(Htra2)
HGL: 
101725239(Htra2)
TUP: 
102501824(HTRA2)
CFA: 
475782(HTRA2)
AML: 
FCA: 
768259(HTRA2)
PTG: 
102968855(HTRA2)
BTA: 
523039(HTRA2)
BOM: 
PHD: 
102334875(HTRA2)
CHX: 
102181963(HTRA2)
OAS: 
101120228(HTRA2)
SSC: 
CFR: 
102522927(HTRA2)
BACU: 
103003966(HTRA2)
LVE: 
103086746(HTRA2)
ECB: 
100053688(HTRA2)
MYB: 
102242360(HTRA2)
MYD: 
102772576(HTRA2)
PALE: 
102890616(HTRA2)
MDO: 
100025882(HTRA2)
SHR: 
100923981(HTRA2)
GGA: 
395990(HTRA2)
MGP: 
FAB: 
101806812(HTRA2)
PHI: 
102107154(HTRA2)
APLA: 
101802615(HTRA2)
FPG: 
101914636(HTRA2)
FCH: 
102050387(HTRA2)
CLV: 
102085893(HTRA2)
ASN: 
102378167(HTRA2)
AMJ: 
102573820(HTRA2)
PSS: 
102456624(HTRA2)
CMY: 
102937290(HTRA2)
ACS: 
100565079(htra2)
PBI: 
XTR: 
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102356234(HTRA2)
CMK: 
BFO: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
551969(HtrA2)
NVI: 
TCA: 
BMOR: 
100533207(htra2)
PHU: 
ISC: 
TSP: 
HMG: 
AQU: 
ALY: 
CCP: 
PIF: 
 » show all
Taxonomy
Reference
1  [PMID:12835328]
  Authors
Srinivasula SM, Gupta S, Datta P, Zhang Z, Hegde R, Cheong N, Fernandes-Alnemri T, Alnemri ES.
  Title
Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2.
  Journal
J. Biol. Chem. 278 (2003) 31469-72.
Reference
2  [PMID:10873535]
  Authors
Savopoulos JW, Carter PS, Turconi S, Pettman GR, Karran EH, Gray CW, Ward RV, Jenkins O, Creasy CL.
  Title
Expression, purification, and functional analysis of the human serine protease HtrA2.
  Journal
Protein. Expr. Purif. 19 (2000) 227-34.
  Sequence
[hsa:27429]
Reference
3  [PMID:14512424]
  Authors
Martins LM, Turk BE, Cowling V, Borg A, Jarrell ET, Cantley LC, Downward J.
  Title
Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi.
  Journal
J. Biol. Chem. 278 (2003) 49417-27.
  Sequence
[hsa:27429]
Reference
4  [PMID:10971580]
  Authors
Gray CW, Ward RV, Karran E, Turconi S, Rowles A, Viglienghi D, Southan C, Barton A, Fantom KG, West A, Savopoulos J, Hassan NJ, Clinkenbeard H, Hanning C, Amegadzie B, Davis JB, Dingwall C, Livi GP, Creasy CL.
  Title
Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response.
  Journal
Eur. J. Biochem. 267 (2000) 5699-710.
  Sequence
[hsa:27429] [mmu:64704]
Reference
5  [PMID:11967569]
  Authors
Li W, Srinivasula SM, Chai J, Li P, Wu JW, Zhang Z, Alnemri ES, Shi Y.
  Title
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi.
  Journal
Nat. Struct. Biol. 9 (2002) 436-41.
  Sequence
[hsa:27429]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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